Science

sleeping-more-flushes-junk-out-of-the-brain

Sleeping more flushes junk out of the brain

Biology, brain, Neuroscience, Science, sleep / /

Better sleep on it —

Rhythmic activity during sleep may get fluids in the brain moving.

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Abstract image of a pink brain against a blue background.

As if we didn’t have enough reasons to get at least eight hours of sleep, there is now one more. Neurons are still active during sleep. We may not realize it, but the brain takes advantage of this recharging period to get rid of junk that was accumulating during waking hours.

Sleep is something like a soft reboot. We knew that slow brainwaves had something to do with restful sleep; researchers at the Washington University School of Medicine in St. Louis have now found out why. When we are awake, our neurons require energy to fuel complex tasks such as problem-solving and committing things to memory. The problem is that debris gets left behind after they consume these nutrients. As we sleep, neurons use these rhythmic waves to help move cerebrospinal fluid through brain tissue, carrying out metabolic waste in the process.

In other words, neurons need to take out the trash so it doesn’t accumulate and potentially contribute to neurodegenerative diseases. “Neurons serve as master organizers for brain clearance,” the WUSTL research team said in a study recently published in Nature.

Built-in garbage disposal

Human brains (and those of other higher organisms) evolved to have billions of neurons in the functional tissue, or parenchyma, of the brain, which is protected by the blood-brain barrier.

Everything these neurons do creates metabolic waste, often in the form of protein fragments. Other studies have found that these fragments may contribute to neurodegenerative diseases such as Alzheimer’s.

The brain has to dispose of its garbage somehow, and it does this through what’s called the glymphatic system (no, that’s not a typo), which carries cerebrospinal fluid that moves debris out of the parenchyma through channels located near blood vessels. However, that still left the questions: What actually powers the glymphatic system to do this—and how? The WUSTL team wanted to find out.

To see what told the glymphatic system to dump the trash, scientists performed experiments on mice, inserting probes into their brains and planting electrodes in the spaces between neurons. They then anesthetized the mice with ketamine to induce sleep.

Neurons fired strong, charged currents after the animals fell asleep. While brain waves under anesthesia were mostly long and slow, they induced corresponding waves of current in the cerebrospinal fluid. The fluid would then flow through the dura mater, the outer layer of tissue between the brain and the skull, taking the junk with it.

Just flush it

The scientists wanted to be sure that neurons really were the force that pushed the glymphatic system into action. To do that, they needed to genetically engineer the brains of some mice to nearly eliminate neuronal activity while they were asleep (though not to the point of brain death) while leaving the rest of the mice untouched for comparison.

In these engineered mice, the long, slow brain waves seen before were undetectable. As a result, the fluid was no longer pushed to carry metabolic waste out of the brain. This could only mean that neurons had to be active in order for the brain’s self-cleaning cycle to work.

Furthermore, the research team found that there were fluctuations in the brain waves of the un-engineered mice, with slightly faster waves thought to be targeted at the debris that was harder to remove (at least, this is what the researchers hypothesized). It is not unlike washing a plate and then needing to scrub slightly harder in places where there is especially stubborn residue.

The researchers also found out why previous experiments produced different results. Because the flushing out of cerebrospinal fluid that carries waste relies so heavily on neural activity, the type of anesthetic used mattered—anesthetics that inhibit neural activity can interfere with the results. Other earlier experiments worked poorly because of injuries caused by older and more invasive methods of implanting the monitoring hardware into brain tissues. This also disrupted neurons.

“The experimental methodologies we used here largely avoid acute damage to the brain parenchyma, thereby providing valuable strategies for further investigations into neural dynamics and brain clearance,” the team said in the same study.

Now that neurons are known to set the glymphatic system into motion, more attention can be directed towards the intricacies of that process. Finding out more about the buildup and cleaning of metabolic waste may contribute to our understanding of neurodegenerative diseases. It’s definitely something to think about before falling asleep.

Nature, 2024.  DOI: 10.1038/s41586-024-07108-6

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Why do some people always get lost?

navigation, Science, syndication / /

I don’t know where I’m going —

Experience may matter more than innate ability when it comes to sense of direction.

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Scientists are homing in on how navigation skills develop.

Enlarge / Scientists are homing in on how navigation skills develop.

Knowable Magazine (CC BY-ND)

Like many of the researchers who study how people find their way from place to place, David Uttal is a poor navigator. “When I was 13 years old, I got lost on a Boy Scout hike, and I was lost for two and a half days,” recalls the Northwestern University cognitive scientist. And he’s still bad at finding his way around.

The world is full of people like Uttal—and their opposites, the folks who always seem to know exactly where they are and how to get where they want to go. Scientists sometimes measure navigational ability by asking someone to point toward an out-of-sight location—or, more challenging, to imagine they are someplace else and point in the direction of a third location—and it’s immediately obvious that some people are better at it than others.

“People are never perfect, but they can be as accurate as single-digit degrees off, which is incredibly accurate,” says Nora Newcombe, a cognitive psychologist at Temple University who coauthored a look at how navigational ability develops in the 2022 Annual Review of Developmental Psychology. But others, when asked to indicate the target’s direction, seem to point at random. “They have literally no idea where it is.”

While it’s easy to show that people differ in navigational ability, it has proved much harder for scientists to explain why. There’s new excitement brewing in the navigation research world, though. By leveraging technologies such as virtual reality and GPS tracking, scientists have been able to watch hundreds, sometimes even millions, of people trying to find their way through complex spaces, and to measure how well they do. Though there’s still much to learn, the research suggests that to some extent, navigation skills are shaped by upbringing.

Nurturing navigation skills

The importance of a person’s environment is underscored by a recent look at the role of genetics in navigation. In 2020, Margherita Malanchini, a developmental psychologist at Queen Mary University of London, and her colleagues compared the performance of more than 2,600 identical and nonidentical twins as they navigated through a virtual environment to test whether navigational ability runs in families. It does, they found—but only modestly. Instead, the biggest contributor to people’s performance was what geneticists call the “nonshared environment”—that is, the unique experiences each person accumulates as their life unfolds. Good navigators, it appears, are mostly made, not born.

A remarkable, large-scale experiment led by Hugo Spiers, a cognitive neuroscientist at University College London, gave researchers a glimpse at how experience and other cultural factors might influence wayfinding skills. Spiers and his colleagues, in collaboration with the telecom company T-Mobile, developed a game for cellphones and tablets, Sea Hero Quest, in which players navigate by boat through a virtual environment to locate a series of checkpoints. The game app asked participants to provide basic demographic data, and nearly 4 million worldwide did so. (The app is no longer accepting new participants except by invitation of researchers.)

Through the app, the researchers were able to measure wayfinding ability by the total distance each player traveled to reach all the checkpoints. After completing some levels of the game, players also had to shoot a flare back toward their point of origin—a dead-reckoning test analogous to the pointing-to-out-of-sight-locations task. Then Spiers and his colleagues could compare players’ performance to the demographic data.

Several cultural factors were associated with wayfinding skills, they found. People from Nordic countries tended to be slightly better navigators, perhaps because the sport of orienteering, which combines cross-country running and navigation, is popular in those countries. Country folk did better, on average, than people from cities. And among city-dwellers, those from cities with more chaotic street networks such as those in the older parts of European cities did better than those from cities like Chicago, where the streets form a regular grid, perhaps because residents of grid cities don’t need to build such complex mental maps.

Why do some people always get lost? Read More »

how-new-tech-is-making-geothermal-energy-a-more-versatile-power-source

How new tech is making geothermal energy a more versatile power source

Energy, geothermal power, Science, syndication / /

Energy rising —

Geothermal has moved beyond being confined to areas with volcanic activity.

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The Nesjavellir Geothermal Power Station. Geothermal power has long been popular in volcanic countries like Iceland, where hot water bubbles from the ground.

Enlarge / The Nesjavellir Geothermal Power Station. Geothermal power has long been popular in volcanic countries like Iceland, where hot water bubbles from the ground.

Gretar Ívarsson/Wikimedia Commons

Glistening in the dry expanses of the Nevada desert is an unusual kind of power plant that harnesses energy not from the sun or wind, but from the Earth itself.

Known as Project Red, it pumps water thousands of feet into the ground, down where rocks are hot enough to roast a turkey. Around the clock, the plant sucks the heated water back up to power generators. Since last November, this carbon-free, Earth-borne power has been flowing onto a local grid in Nevada.

Geothermal energy, though it’s continuously radiating from Earth’s super-hot core, has long been a relatively niche source of electricity, largely limited to volcanic regions like Iceland where hot springs bubble from the ground. But geothermal enthusiasts have dreamed of sourcing Earth power in places without such specific geological conditions—like Project Red’s Nevada site, developed by energy startup Fervo Energy.

Such next-generation geothermal systems have been in the works for decades, but they’ve proved expensive and technologically difficult, and have sometimes even triggered earthquakes. Some experts hope that newer efforts like Project Red may now, finally, signal a turning point, by leveraging techniques that were honed in oil and gas extraction to improve reliability and cost-efficiency.

The advances have garnered hopes that with enough time and money, geothermal power—which currently generates less than 1 percent of the world’s electricity, and 0.4 percent of electricity in the United States—could become a mainstream energy source. Some posit that geothermal could be a valuable tool in transitioning the energy system off of fossil fuels, because it can provide a continuous backup to intermittent energy sources like solar and wind. “It’s been, to me, the most promising energy source for a long time,” says energy engineer Roland Horne of Stanford University. “But now that we’re moving towards a carbon-free grid, geothermal is very important.”

A rocky start

Geothermal energy works best with two things: heat, plus rock that is permeable enough to carry water. In places where molten rock sizzles close to the surface, water will seep through porous volcanic rock, warm up and bubble upward as hot water, steam, or both.

If the water or steam is hot enough—ideally at least around 300 degrees Fahrenheit—it can be extracted from the ground and used to power generators for electricity. In Kenya, nearly 50 percent of electricity generated comes from geothermal. Iceland gets 25 percent of its electricity from this source, while New Zealand gets about 18 percent and the state of California, 6 percent.

Some natural geothermal resources are still untapped, such as in the western United States, says geologist Ann Robertson-Tait, president of GeothermEx, a geothermal energy consulting division at the oilfield services company SLB. But by and large, we’re running out of natural, high-quality geothermal resources, pushing experts to consider ways of extracting geothermal energy from areas where the energy is much harder to access. “There’s so much heat in the Earth,” Robertson-Tait says. But, she adds, “much of it is locked inside rock that isn’t permeable.”

The Lardarello plant in the Tuscany region of Italy was the first geothermal power plant in the world. It was completed in 1913.

Enlarge / The Lardarello plant in the Tuscany region of Italy was the first geothermal power plant in the world. It was completed in 1913.

Tapping that heat requires deep drilling and creating cracks in these non-volcanic, dense rocks to allow water to flow through them. Since 1970, engineers have been developing “enhanced geothermal systems” (EGS) that do just that, applying methods similar to the hydraulic fracturing—or fracking—used to suck oil and gas out of deep rocks. Water is pumped at high pressure into wells, up to several miles deep, to blast cracks into the rocks. The cracked rock and water create an underground radiator where water heats before rising to the surface through a second well. Dozens of such EGS installations have been built in the United States, Europe, Australia, and Japan—most of them experimental and government-funded—with mixed success.

Famously, one EGS plant in South Korea was abruptly shuttered in 2017 after having probably caused a 5.5-magnitude earthquake; fracking of any kind can add pressure to nearby tectonic faults. Other issues were technological—some plants didn’t create enough fractures for good heat exchange, or fractures traveled in the wrong direction and failed to connect the two wells.

Some efforts, however, turned into viable power plants, including several German and French systems built between 1987 and 2012 in the Rhine Valley. There, engineers made use of existing fractures in the rock.

But overall, there just hasn’t been enough interest to develop EGS into a more reliable and lucrative technology, says geophysicist Dimitra Teza of the energy research institute Fraunhofer IEG in Karlsruhe, Germany, who helped develop some of the Rhine Valley EGS systems. “It has been quite tough for the industry.”

Geothermal electricity has long been limited to volcanic regions where underground heat is easily accessible. But new kinds of power plants are making it possible to derive geothermal heat elsewhere in the world.

Enlarge / Geothermal electricity has long been limited to volcanic regions where underground heat is easily accessible. But new kinds of power plants are making it possible to derive geothermal heat elsewhere in the world.

How new tech is making geothermal energy a more versatile power source Read More »

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Rocket Report: Delta IV’s grand finale; Angara flies another dummy payload

rocket report, Science, Space / /
The Angara A5 rocket launched this week from Vostochny for the first time.

Enlarge / The Angara A5 rocket launched this week from Vostochny for the first time.

Roscosmos

Welcome to Edition 6.39 of the Rocket Report! The big news this week came from United Launch Alliance, and the final mission of its Delta IV Heavy rocket. Both Stephen and I had thoughts about this launch, which is bittersweet, and we expressed them in stories linked below. It’s been a little less than 20 years since this big rocket debuted, and interesting to think how very much the launch industry has changed since then.

As always, we welcome reader submissions, and if you don’t want to miss an issue, please subscribe using the box below (the form will not appear on AMP-enabled versions of the site). Each report will include information on small-, medium-, and heavy-lift rockets as well as a quick look ahead at the next three launches on the calendar.

Rocket Lab to reuse flight tank. On Wednesday Rocket Lab said it is returning a previously flown Electron rocket first stage tank to the production line for the first time in preparation for reflying the stage. The company characterized this as a “significant” milestone as it seeks to make Electron the world’s first reusable small rocket. This stage was successfully launched and recovered as part of the ‘Four of a Kind’ mission earlier this year on January 31.

Iterating a path to reuse … The stage will now undergo final fit out and rigorous qualification for reuse. “Our key priority in pushing this stage back into the standard production flow for the first time is to ensure our systems and qualification processes are fit for accepting pre-flown boosters at scale,” said Rocket Lab founder and CEO Peter Beck. “If this stage successfully passes and is accepted for flight, we’ll consider opportunities for reflying it in the new year.” (submitted by Ken the Bin)

Virgin Orbit IP for sale on LinkedIn. In a post this week on the social networking site LinkedIn, former Virgin Orbit chief executive Dan Hart said that the Virgin Orbit IP library is being made available for licensing. “The flight-proven LauncherOne IP can accelerate launch and hypersonic system development schedules by years, and enable significant cost savings,” Hart wrote. “The innovative designs can also offer component/subsystem providers immediate product line expansion.”

Yours for a low, low price … The IP library includes all manner of goodies, including an FAA-approved flight termination system, the Newton 3 and Newton 4 engines, avionics, structures, and more. Price for access to all IP is $3 million for a nonexclusive license, Hart said. I have no idea whether that’s a good price or not.

The easiest way to keep up with Eric Berger’s space reporting is to sign up for his newsletter, we’ll collect his stories in your inbox.

Virgin Galactic countersues Boeing. Virgin Galactic has filed a countersuit against Boeing over a project to develop a new mothership aircraft, arguing in part that Boeing performed poorly, Space News reports. The suit, filed last week in the US District Court for the Central District of California, comes two weeks after Boeing filed suit against Virgin Galactic, alleging that Virgin refused to pay more than $25 million in invoices on the project and misappropriated trade secrets.

Citing Boeing’s own record … The dispute revolves around a project announced in 2022 to develop a new aircraft that would replace Virgin’s existing VMS Eve as an air-launch platform. Virgin, in its suit, claims that Boeing performed “shoddy and incomplete” work on the initial phases of the project. “Boeing’s failures with respect to its agreement with Virgin Galactic are consistent with Boeing’s record of poor quality control and mismanagement,” the complaint states. (submitted by EllPeaTea)

Navy awards contract to Ursa Major. The rocket propulsion startup said Monday it has signed a contract with the United States Navy to develop and test solid fuel rocket engines in an effort to develop a next generation of solid rocket motor for the Navy’s standard missile program, Reuters reports. The agreement is part of a series of prototype engine contracts being awarded by the US Navy as it seeks to expand the industrial base for manufacturing them.

Broadening the US supplier base … The deal comes as the Navy is seeing a surge in missile demand due to the ongoing conflicts in Gaza and Yemen and the war in Ukraine. “Our new approach to manufacturing solid rocket motors allows Ursa Major to quickly develop high-performing motors at scale, driving volume and cost efficiencies to address this critical national need,” said Ursa Major Founder Joe Laurienti. (submitted by Ken the Bin)

Rocket Report: Delta IV’s grand finale; Angara flies another dummy payload Read More »

a-supernova-caused-the-boat-gamma-ray-burst,-jwst-data-confirms

A supernova caused the BOAT gamma ray burst, JWST data confirms

astronomy, astrophysics, B.O.A.T., Gamma ray bursts, nucleosynthesis, Physics, Science, Webb telescope / /

Still the BOAT —

But astronomers are puzzled by the lack of signatures of expected heavy elements.

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Artist's visualization of GRB 221009A showing the narrow relativistic jets — emerging from a central black hole — that gave rise to the brightest gamma ray burst yet detected.

Enlarge / Artist’s visualization of GRB 221009A showing the narrow relativistic jets—emerging from a central black hole—that gave rise to the brightest gamma-ray burst yet detected.

Aaron M. Geller/Northwestern/CIERA/ ITRC&DS

In October 2022, several space-based detectors picked up a powerful gamma-ray burst so energetic that astronomers nicknamed it the BOAT (Brightest Of All Time). Now they’ve confirmed that the GRB came from a supernova, according to a new paper published in the journal Nature Astronomy. However, they did not find evidence of heavy elements like platinum and gold one would expect from a supernova explosion, which bears on the longstanding question of the origin of such elements in the universe.

As we’ve reported previously, gamma-ray bursts are extremely high-energy explosions in distant galaxies lasting between mere milliseconds to several hours. There are two classes of gamma-ray bursts. Most (70 percent) are long bursts lasting more than two seconds, often with a bright afterglow. These are usually linked to galaxies with rapid star formation. Astronomers think that long bursts are tied to the deaths of massive stars collapsing to form a neutron star or black hole (or, alternatively, a newly formed magnetar). The baby black hole would produce jets of highly energetic particles moving near the speed of light, powerful enough to pierce through the remains of the progenitor star, emitting X-rays and gamma rays.

Those gamma-ray bursts lasting less than two seconds (about 30 percent) are deemed short bursts, usually emitting from regions with very little star formation. Astronomers think these gamma-ray bursts are the result of mergers between two neutron stars, or a neutron star merging with a black hole, comprising a “kilonova.” That hypothesis was confirmed in 2017 when the LIGO collaboration picked up the gravitational wave signal of two neutron stars merging, accompanied by the powerful gamma-ray bursts associated with a kilonova.

The October 2022 gamma-ray burst falls into the long category, lasting over 300 seconds. GRB 221009A triggered detectors aboard NASA’s Fermi Gamma-ray Space Telescope, the Neil Gehrels Swift Observatory, and Wind spacecraft, among others, just as gamma-ray astronomers had gathered for an annual meeting in Johannesburg, South Africa. The powerful signal came from the constellation Sagitta, traveling some 1.9 billion years to Earth.

Several papers were published last year reporting on the analytical results of all the observational data. Those findings confirmed that GRB 221009A was indeed the BOAT, appearing especially bright because its narrow jet was pointing directly at Earth. But the various analyses also yielded several surprising results that puzzled astronomers. Most notably, a supernova should have occurred a few weeks after the initial burst, but astronomers didn’t detect one, perhaps because it was very faint, and thick dust clouds in that part of the sky were dimming any incoming light.

Swift’s X-ray Telescope captured the afterglow of GRB 221009A about an hour after it was first detected.

Enlarge / Swift’s X-ray Telescope captured the afterglow of GRB 221009A about an hour after it was first detected.

NASA/Swift/A. Beardmore (University of Leicester)

That’s why Peter Blanchard of Northwestern University and his fellow co-authors decided to wait six months before undertaking their own analysis, relying on data collected during the GRB’s later phase by the Webb Space Telescope’s Near Infrared Spectrograph. They augmented that spectral data with observations from ALMA (Atacama Large Millimeter/Submillimeter Array) in Chile so they could separate light from the supernova and the GRB afterglow. The most significant finding was the telltale signatures of key elements like calcium and oxygen that one would expect to find with a supernova.

Yet the supernova wasn’t brighter than other supernovae associated with less energetic GRBs, which is puzzling. “You might expect that the same collapsing star producing a very energetic and bright GRB would also produce a very energetic and bright supernova,” said Blanchard. “But it turns out that’s not the case. We have this extremely luminous GRB, but a normal supernova.” The authors suggest that this might have something to do with the shape and structure of the relativistic jet, which was much narrower than other GRB jets, resulting in a more focused and brighter beam of light.

The data held another surprise for astronomers. The only confirmed source of heavy elements in the universe to date is the merging of binary neutron stars. But per Blanchard, there are far too few neutron star mergers to account for the abundance of heavy elements, so there must be another source. One hypothetical additional source is a rapidly spinning massive star that collapses and explodes into a supernova. Alas, there was no evidence of heavy elements in the JWST spectral data regarding the BOAT.

“When we confirmed that the GRB was generated by the collapse of a massive star, that gave us the opportunity to test a hypothesis for how some of the heaviest elements in the universe are formed,” said Blanchard. “We did not see signatures of these heavy elements, suggesting that extremely energetic GRBs like the BOAT do not produce these elements. That doesn’t mean that all GRBs do not produce them, but it’s a key piece of information as we continue to understand where these heavy elements come from. Future observations with JWST will determine if the BOAT’s ‘normal’ cousins produce these elements.”

Nature Astronomy, 2024. DOI: 10.1038/s41550-024-02237-4  (About DOIs).

A supernova caused the BOAT gamma ray burst, JWST data confirms Read More »

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US drug shortages reach record high with 323 meds now in short supply

adderall, ASHP, cancer drugs, DEA, drug shortages, fda, generic drugs, health, pharmacists, pharmacy, Science / /

Terrible —

The shortages affect everything from generic cancer drugs to ADHD medication.

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Takeda Pharmaceutical Co. Adderall XR brand medication arranged at a pharmacy in Provo, Utah, in November 2023.

Enlarge / Takeda Pharmaceutical Co. Adderall XR brand medication arranged at a pharmacy in Provo, Utah, in November 2023.

Drug shortages in the US have reached an all-time high, with 323 active and ongoing shortages already tallied this year, according to data collected by the American Society of Health-System Pharmacists (ASHP).

The current drug shortage total surpasses the previous record of 320, set in 2014, and is the highest recorded since ASHP began tracking shortages in 2001.

“All drug classes are vulnerable to shortages,” ASHP CEO Paul Abramowitz said in a statement Thursday. “Some of the most worrying shortages involve generic sterile injectable medications, including cancer chemotherapy drugs and emergency medications stored in hospital crash carts and procedural areas. Ongoing national shortages of therapies for attention-deficit/hyperactivity disorder [ADHD] also remain a serious challenge for clinicians and patients.”

Erin Fox, associate chief pharmacy officer of University of Utah Health, told CBS MoneyWatch, that most of the drugs in short supply are generic, older products, and around half are injectable drugs that require more stringent manufacturing processes.

There are myriad reasons for the hundreds of drug shortages now facing doctors and patients, many of which remain unclear. But, as Ars has reported before, the root cause of shortages of low-cost, off-patent generic drugs is well established. These drugs have razor-thin to non-existent profit margins, driven by middle managers who have, in recent years, pushed down wholesale prices to rock-bottom levels. In some cases, generic manufacturers lose money on the drugs, disincentivizing other players in the pharmaceutical industry from stepping in to bolster fragile supply chains. Several generic manufacturers have filed for bankruptcy recently.

For other drugs, the situation is more complicated. The ADHD drug Adderall, for instance, has been in critical shortage since October 2022, causing millions of patients around the country to struggle to fill their prescriptions. It began when a manufacturing delay for one manufacturer kicked off a shortfall. Although that problem has since been resolved, it came amid a significant increase in Adderall prescriptions, which spiked further during the pandemic when telehealth prescribing became more common. Additionally, because Adderall—made of amphetamine-mixed salts—is a controlled substance, the Drug Enforcement Administration sets limits or “quotas” on how much of it manufacturers can make. Such quotas can exacerbate shortages, ASHP said.

But, in a joint letter with the Food and Drug Administration last August, the DEA said that, by its data, manufacturers of amphetamine products (including Adderall) only sold approximately 70 percent of their allotted quotas in 2022. That meant that there were approximately 1 billion more doses that they could have produced but did not make or ship. At the time, the agencies said its 2023 data was trending in the same direction.

In 60 percent of cases, manufacturers do not know or do not provide reasons why their drugs fall into short supply, ASHP found.

The organization has put forth policy recommendations to prevent shortages and improve supply chains, advocating for federal and regulatory changes. “Much work remains to be done at the federal level to fix the root causes of drug shortages,” Abramowitz said. “ASHP will continue to engage with policymakers regularly as we guide efforts to draft and pass new legislation to address drug shortages and continue to strongly advocate on behalf of our members for solutions that work.”

US drug shortages reach record high with 323 meds now in short supply Read More »

texas-surgeon-accused-of-secretly-blocking-patients-from-getting-transplants

Texas surgeon accused of secretly blocking patients from getting transplants

data manipulation, kidney, liver, Science, texas, transplant / /

Bizarre —

The motive for the alleged data manipulation is unknown.

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Texas surgeon accused of secretly blocking patients from getting transplants

An accomplished and prominent transplant surgeon in Texas allegedly falsified patient data in a government transplant waiting list, which may have prevented his own patients from receiving lifesaving liver transplants, according to media reports and hospital statements.

Memorial Hermann-Texas Medical Center halted its liver transplant program on April 3 after finding “irregularities” with donor acceptance criteria, the Houston Chronicle reported based on a statement from the hospital. At the time there were 38 patients on the hospital’s wait list for a liver. Earlier this week, the hospital also halted its kidney transplant program, telling the Chronicle that it was pausing operations to “evaluate a new physician leadership structure.”

Memorial Hermann has not named the surgeon behind the “inappropriate changes,” but The New York Times identified him as Dr. Steve Bynon, a surgeon who has received numerous accolades and, at one point, appears to have been featured on a billboard. Bynon oversaw both the liver and kidney transplant programs at Memorial Hermann.

According to the Times, the hospital said that a doctor in its liver transplant program had admitted to changing patient records, and those changes led to patients being denied transplants. Officials who spoke with the Times identified said physician as Bynon.

Bynon is a surgical transplant director at the University of Texas Health Science Center at Houston (UTHealth Houston), as well as the leader of Memorial Hermann’s abdominal transplant program. Ars was not able to reach Bynon for comment. When reporters for the Times reached Bynon by phone Thursday, he did not confirm that he had admitted to manipulating the data and referred further questions to UTHealth Houston.

On Friday, UTHealth Houston released a statement defending Bynon, saying that he is “an exceptionally talented and caring physician, and a pioneer in abdominal organ transplantation.” The statement continued by saying that the survival rates and outcomes for Dr. Bynon’s transplant patients are among the best in the country. “Our faculty and staff members, including Dr. Bynon, are assisting with the inquiry into Memorial Hermann’s liver transplant program and are committed to addressing and resolving any findings identified by this process,” it said.

Officials at Memorial Hermann told the Times that the data allegedly manipulated involved criteria for organ donors. When doctors place patients on a waiting list for an organ donation, they specify criteria for acceptable donors. This includes factors like a potential donor’s age and weight. But, according to the officials, entries for some of the patients in Bynon’s program had criteria that were set to impossible conditions, such as a patient only accepting organs from a toddler who weighed 300 pounds. This effectively made Bynon’s patients ineligible for a transplant.

The Chronicle notes that Memorial Hermann has seen increasing numbers of liver transplant candidates die or become too sick for a transplant while on the waitlist. According to federal data, in 2021, only four patients died or got too sick for a transplant while on the hospital’s liver transplant waiting list. In 2022, the number increased to 11, and in 2023, it was 14. So far this year, there are five patients who have died or gotten too sick while waiting.

If the allegations are true, it’s unclear what motivated Bynon to alter the data.

It’s also unclear when the hospital’s transplant programs will resume. In a statement Friday, Memorial Hermann said it is working to “make the necessary changes that will allow for the quick reactivation of the kidney transplant program under a different physician leadership structure.” It did not address when the liver transplant program may resume.

Texas surgeon accused of secretly blocking patients from getting transplants Read More »

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SpaceX’s most-flown reusable rocket will go for its 20th launch tonight

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File photo of a Falcon 9 rocket rolling out of its hangar at Cape Canaveral Space Force Station, Florida.

Enlarge / File photo of a Falcon 9 rocket rolling out of its hangar at Cape Canaveral Space Force Station, Florida.

For the first time, SpaceX will launch one of its reusable Falcon 9 boosters for a 20th time Friday night on a flight to deliver 23 more Starlink Internet satellites to orbit.

This milestone mission is scheduled to lift off at 9: 22 pm EDT Friday (01: 22 UTC Saturday) from Space Launch Complex 40 (SLC-40) at Cape Canaveral Space Force Station, Florida. Forecasters from the US Space Force predict “excellent” weather for the primetime launch.

Falcon 9 will blaze a familiar trail into space, following the same profile as dozens of past Starlink missions.

The rocket’s first-stage booster will shut off its nine kerosene-fueled Merlin engines about two-and-a-half minutes into the flight, reaching a top speed of more than 5,000 mph (8,000 km per hour). The first stage will detach from the Falcon 9’s upper stage, which will continue firing into orbit. The 15-story-tall Falcon 9 booster, meanwhile, will follow an arcing trajectory before braking for a vertical landing on a drone ship floating in the Atlantic Ocean near the Bahamas.

The 23 flat-packed Starlink spacecraft will deploy from the upper stage a little more than an hour after liftoff, bringing the total number of Starlinks in low-Earth orbit to more than 5,800 spacecraft.

A hunger for launch

Pretty much every day, SpaceX is either launching a rocket or rolling one out of the hangar to the launch pad. At this pace, SpaceX is redefining what is routine in the space industry, but the rapid-fire launch rate also means the company is continually breaking records, mostly its own.

Friday night’s launch will break another one of those records. This first-stage booster, designated by the tail number B1062, has flown 19 times since its first flight in November 2020. The booster will now be the first in SpaceX’s inventory to go for a 20th flight, breaking a tie with three other rockets as the company’s fleet leader.

When SpaceX debuted the latest version of its Falcon 9 rocket, the Falcon 9 Block 5, officials said the reusable first stage could fly 10 times with minimal refurbishment and perhaps additional flights with a more extensive overhaul. Now, SpaceX is certifying Falcon 9 boosters for 40 flights.

This particular rocket has not undergone any extended maintenance or long-term grounding. It has flown an average of once every two months since debuting three-and-a-half years ago. So the 20-flight milestone SpaceX will achieve Friday night means this rocket has doubled its original design life and, at the same time, has reached the halfway point of its extended service life.

In its career, this booster has launched eight people and 530 spacecraft, mostly Starlinks. The rocket’s first two flights launched GPS navigation satellites for the US military, then it launched two commercial human spaceflight missions with Dragon crew capsules. These were the all-private Inspiration4 mission and Axiom Mission 1, the first fully commercial crew flight to the International Space Station.

A SpaceX Falcon 9 rocket lifts off Sunday, April 7, on the Bandwagon 1 rideshare mission.

Enlarge / A SpaceX Falcon 9 rocket lifts off Sunday, April 7, on the Bandwagon 1 rideshare mission.

Remarkably, this will be the sixth Falcon 9 launch in less than eight days, more flights than SpaceX’s main US rival, United Launch Alliance, has launched in 17 months.

It will be the 38th Falcon 9 launch of the year and the 111th flight of a Falcon 9 or Falcon Heavy rocket—the 114th launch by SpaceX overall—in the last 365 days. More than a third of SpaceX’s Falcon 9 or Falcon Heavy missions, a number that will stand at 332 after Friday night’s flight, have launched in the past year.

This month, for the first time, SpaceX demonstrated it could launch two Falcon 9 rockets in less than five days from the company’s launch pad at Vandenberg Space Force Base, California. SpaceX has also cut the turnaround time between Falcon 9 rockets at Launch Complex 39A at NASA’s Kennedy Space Center. The company’s most-used launch pad, SLC-40, can handle two Falcon 9 flights in less than four days.

It’s not just launch pad turnaround. SpaceX uses its drone ships—two based in Florida and one in California—for most Falcon 9 landings. In order to meet the appetite for Falcon 9 launches, SpaceX is getting rockets back to port and re-deploying drone ships back to sea at a faster rate.

SpaceX’s most-flown reusable rocket will go for its 20th launch tonight Read More »

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The Space Force is planning what could be the first military exercise in orbit

Commercial space, military exercise, military space, rocket lab, Science, Space, space domain awareness, true anomaly, US Space Force, victus haze / /
Artist's illustration of two satellites performing rendezvous and proximity operations in low-Earth orbit.

Enlarge / Artist’s illustration of two satellites performing rendezvous and proximity operations in low-Earth orbit.

The US Space Force announced Thursday it is partnering with two companies, Rocket Lab and True Anomaly, for a first-of-its-kind mission to demonstrate how the military might counter “on-orbit aggression.”

On this mission, a spacecraft built and launched by Rocket Lab will chase down another satellite made by True Anomaly, a Colorado-based startup. “The vendors will exercise a realistic threat response scenario in an on-orbit space domain awareness demonstration called Victus Haze,” the Space Force’s Space Systems Command said in a statement.

This threat scenario could involve a satellite performing maneuvers that approach a US spacecraft or a satellite doing something else unusual or unexpected. In such a scenario, the Space Force wants to have the capability to respond, either to deter an adversary from taking action or to defend a US satellite from an attack.

Going up to take a look

“When another nation puts an asset up into space and we don’t quite know what that asset is, we don’t know what its intent is, we don’t know what its capabilities are, we need the ability to go up there and figure out what this thing is,” said Gen. Michael Guetlein, the Space Force’s vice chief of space operations.

This is what the Space Force wants to demonstrate with Victus Haze. For this mission, True Anomaly’s spacecraft will launch first, posing as a satellite from a potential adversary, like China or Russia. Rocket Lab will have a satellite on standby to go up and inspect True Anomaly’s spacecraft and will launch it when the Space Force gives the launch order.

“Pretty sporty,” said Even Rogers, co-founder and CEO of True Anomaly.

Then, if all goes according to plan, the two spacecraft will switch roles, with True Anomaly’s Jackal satellite actively maneuvering around Rocket Lab’s satellite. According to the Space Force, True Anomaly and Rocket Lab will deliver their spacecraft no later than the fall of 2025.

“If a near-peer competitor makes a movement, we need to have it in our quiver to make a counter maneuver, whether that be go up and do a show of force or go up and do space domain awareness or understand the characterization of the environment—what’s going on?” Guetlein said.

Victus Haze is the next in a series of military missions dedicated to validating Tactically Responsive Space (TacRS) capabilities. With these efforts, the Space Force and its commercial partners have shown how they can compress the time it takes to prepare and launch a satellite.

Last year, the Space Force partnered with Firefly Aerospace and Millennium Space Systems on the Victus Nox mission. The Victus Nox satellite was built and tested in less than a year and then readied for launch in less than 60 hours. Firefly successfully launched the spacecraft on its Alpha rocket 27 hours after receiving launch orders from the Space Force, a remarkable achievement in an industry where satellites take years to build and launch campaigns typically last weeks or months.

One of True Anomaly's first two Jackal

Enlarge / One of True Anomaly’s first two Jackal “autonomous orbital vehicles,” which launched in March on a SpaceX rideshare mission.

“We no longer have the luxury of time to wait years, even 10 or 15 years, to deliver some of these capabilities.” Guetlein said in a discussion in January hosted by the Center for Strategic and International Studies. “A tactically relevant timeline is a matter of weeks, days, or even hours.”

“Victus Haze is about continuing to break those paradigms and to show how we would rapidly put up a space domain awareness capability and operate it in real time against a threat,” Guetlein said.

The Victus Haze mission is more complicated than Victus Nox, involving two prime contractors, two spacecraft, and two rocket launches from different spaceports, all timed to occur with short timelines “to keep the demonstration as realistic as possible,” a Space Force spokesperson told Ars.

“This demonstration will ultimately prepare the United States Space Force to provide future forces to combatant commands to conduct rapid operations in response to adversary on-orbit aggression,” Space Systems Command said in a statement.

The Space Force is planning what could be the first military exercise in orbit Read More »

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Researchers find a new organelle evolving

biochemistry, Biology, endosymbiosis, evolution, nitrogen, organelle, Science / /
Image of a single celled algae.

Enlarge / A photo of Braarudosphaera bigelowii with the nitroplast indicated by an arrowhead.

The complex cells that underlie animals and plants have a large collection of what are called organelles—compartments surrounded by membranes that perform specialized functions. Two of these were formed through a process called endosymbiosis, in which a once free-living organism is incorporated into a cell. These are the mitochondrion, where a former bacteria now handles the task of converting chemical energy into useful forms, and the chloroplast, where photosynthesis happens.

The fact that there are only a few cases of organelles that evolved through endosymbiosis suggests that it’s an extremely rare event. Yet researchers may have found a new case, in which an organelle devoted to fixing nitrogen from the atmosphere is in the process of evolving. The resulting organelle, termed a nitroplast, is still in the process of specialization.

Getting nitrogen

Nitrogen is one of the elements central to life. Every DNA base, every amino acid in a protein contains at least one, and often several, nitrogen atoms. But nitrogen is remarkably difficult for life to get ahold of. N2 molecules might be extremely abundant in our atmosphere, but they’re extremely difficult to break apart. The enzymes that can, called nitrogenases, are only found in bacteria, and they don’t work in the presence of oxygen. Other organisms have to get nitrogen from their environment, which is one of the reasons we use so much energy to supply nitrogen fertilizers to many crops.

Some plants (notably legumes), however, can obtain nitrogen via a symbiotic relationship with bacteria. These plants form specialized nodules that provide a habitat for the nitrogen-producing bacteria. This relationship is a form of endosymbiosis, where microbes take up residence inside an organism’s body or cells, with each organism typically providing chemicals that the other needs.

In more extreme cases, endosymbiosis can become obligatory. with neither organism able to survive without the other. In many insects, endosymbionts are passed on to offspring during the production of eggs, and the microbes themselves often lack key genes that would allow them to live independently.

But even states like this fall short of the situation found in mitochondria and chloroplasts. These organelles are thoroughly integrated into the cell, being duplicated and distributed when cells divide. They also have minimal genomes, with most of their proteins made by the cell and imported into the organelles. This level of integration is the product of over a billion years of evolution since the endosymbiotic relationship first started.

It’s also apparently a difficult process, based on its apparent rarity. Beyond mitochondria and chloroplasts, there’s only one confirmed example of a more recent endosymbiosis between eukaryotes and a bacterial species. (There are a number of cases where eukaryotic algae have been incorporated by other eukaryotes. Because these cells have compatible genetics, this occurs with a higher frequency.)

That’s why finding another example is such an exciting prospect.

Researchers find a new organelle evolving Read More »

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Sketchy Botox shots spark multistate outbreak of botulism-like condition

botox, botulism, butulinum toxin, CDC, health, Illinois, Science, tennessee / /

Yikes —

So far at least six people in two states have fallen ill; four of them were hospitalized.

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A woman in New Jersey receiving a Botox treatment at a Botox party in a New Jersey salon hosted by a radio station.

Enlarge / A woman in New Jersey receiving a Botox treatment at a Botox party in a New Jersey salon hosted by a radio station.

Sketchy cosmetic injections of what seem to be counterfeit Botox are behind a multistate outbreak of botulism-like illnesses, state health officials report.

So far, at least six people have fallen ill in two states: four in Tennessee and two in Illinois. Four of the six people required hospitalization for their condition (two in Tennessee and both cases in Illinois).

The Centers for Disease Control and Prevention is reportedly planning to nationwide alert to notify clinicians of the potentially counterfeit Botox and advise them to be on the lookout for botulism-like illnesses. The agency did not immediately respond to Ars’ request for information.

Botox is a regulated drug product that contains purified, controlled quantities of the botulinum neurotoxin, which is made by certain Clostridium bacterial species, especially Clostridium botulinum. The toxin causes muscle paralysis by blocking the release of a neurotransmitter. When people are exposed to the toxin from wound infections or by accidentally eating contaminated foods, it can lead to full paralysis, including in muscles used for breathing. But, the toxin can also be used safely for cosmetic procedures to smooth facial wrinkles—when well-regulated and approved doses administered by licensed medical professionals are used.

All of those important conditions for use did not seem to be met in the cases identified so far. Tennessee reported that its four cases were linked to injections given in “non-medical settings such as homes or cosmetic spas.” Investigators found that the injections were of “products with unclear origin” and that information collected so far suggests the products were counterfeit.

The two people sickened in Illinois, meanwhile, both received injections from a nurse in LaSalle County who was “performing work outside her authority.” State officials said the injections were of Botox or a similar, possibly counterfeit product.

The early symptoms of botulism can include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and difficulty breathing, Tennessee health officials noted. After that, people may suffer descending, symmetric muscle weakness that progresses over hours to days, requiring hospitalization and treatment with an anti-toxin.

Illinois officials reported that the cases reported similar symptoms, such as blurred or double vision, droopy face, fatigue, shortness of breath, difficulty breathing, and a hoarse voice, after getting their injections.

“Illinois residents should exercise caution when considering cosmetic treatment,” Illinois Department of Public Health Director Sameer Vohra said in a statement. “Receiving these treatments in unlicensed, unapproved settings can put you or your loved ones at serious risk for health problems. Please only seek cosmetic services under the care of licensed professionals trained to do these procedures and who use FDA approved products. If you are experiencing any health problems after a recent cosmetic treatment, please contact your healthcare provider immediately for help and assistance.”

Sketchy Botox shots spark multistate outbreak of botulism-like condition Read More »

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Computer scientist wins Turing Award for seminal work on randomness

computational theory, Science, theory of computation, Turing award / /

Foundational questions —

Avi Wigderson helped prove that randomness is not required for efficient computation.

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Avi Wigderton of the Institute for Advanced Study in Princeton is the recipient of the 2023 A.M. Turing Award.

Enlarge / Avi Wigderton of the Institute for Advanced Study in Princeton is the recipient of the 2023 A.M. Turing Award.

Andrea Kane/Institute for Advanced Study

Computational scientist and mathematician Avi Wigderson of the Institute for Advanced Study (IAS) at Princeton University has won the 2023 A.M. Turing Award. The prize, which is given annually by the Association for Computing Machinery (ACM) to a computer scientist for their contributions to the field, comes with $1 million thanks to Google. It is named in honor of the British mathematician Alan Turing, who helped develop a theoretical foundation for understanding machine computation.

Wigderson is being honored “for foundational contributions to the theory of computation, including reshaping our understanding of the role of randomness in computation and for his decades of intellectual leadership in theoretical computer science.” He also won the prestigious Abel Prize (essentially the Nobel for mathematics) in 2021 for his work in theoretical computer science—the first person to be so doubly honored.

“Avi has made fundamental contributions to the theory of computation from parallel algorithms to cryptography to absolutely all aspects of complexity theory,” said Shafi Goldwasser, director of the Simons Institute for the Theory of Computing, who won the 2012 Turing Award. “His numerous contributions over decades to the areas of derandomization and pseudorandomness has led us to a deep understanding of the deep role of randomness in computing.”

Born in Haifa, Israel, Wigderson was the son of an electrical engineer and a nurse. His father passed his own love of solving puzzles and mathematics to his son. Wigderson was an undergraduate at the Technion (Israeli Institute of Technology) and went on to earn his PhD in computer science from Princeton in 1983. He held a few short-term positions before joining the faculty of Hebrew University three years later. He has been with the IAS since 1999 and a full-time resident since 2003.

Wigderton is also recognized as mentor to the next generation of promising young researchers.

Enlarge / Wigderton is also recognized as mentor to the next generation of promising young researchers.

Andrea Kane/Institute for Advanced Study

While computers are fundamentally deterministic systems, researchers discovered in the 1970s that they could enrich their algorithms by letting them make random choices during computation in hopes of improving their efficiency. And it worked. It was easier for computer scientists to start with a randomized version of a deterministic algorithm and then “de-randomize” it to get an algorithm that was deterministic.

In 1994, Wigderson co-authored a seminal paper on hardness versus randomness with Noam Nisan, demonstrating that as useful as randomness can be, it is not a necessity. Essentially, “Every probabilistic algorithm that’s efficient can be replaced by a deterministic one, so you don’t really need [randomness],” he said. “The power believed to be in probabilistic algorithms doesn’t exist.” He subsequently coauthored two more highly influential papers further extending that work on randomness, among many others.

Wigderson’s 2019 book, Mathematics and Computation: A Theory Revolutionizing Technology and Science, is available for download on his website. “One central theme is that computation happens everywhere, not just in computers,” Wigderson told Ars. “It is part of the processes in our brain, the way we can talk and the cells in our body, but also trees growing or weather and celestial things. In all these natural processes, there are the laws of nature, which are local, and they evolve systems. Like in a computer, there are very simple rules, and you start with a problem and discover a complex solution to it. So, the methodology is applicable to essentially any science process or study. There are fantastic collaborations with statistical physics, with quantum physics, with computational biology, with economics, with social science—lots of beautiful, extremely fruitful connections.”

Avi Wigderson in conversation with David Nirenberg, director of the Institute of Advanced Study.

Wigderson’s own research is purely theoretical. “I’m not motivated by applications,” he said. “But I know that fundamental work, we find uses. Think about Alan Turing. He wrote a mathematical paper in logic in an obscure journal about Entscheidungsproblem. It was not motivated by application. But this is what starts computer science. He himself recognized the model he was suggesting is so simple, that we can just start building it.”

That said, he does confess to being pleasantly surprised by the eventual application of his work on zero-knowledge interactive proofs in the mid-1980s. With Silvio Micali and Oded Goldreich, Wigderson extended Micali’s earlier work on interactive proofs to NP problems, concluding that the solution to every such problem can also be proved with a zero-knowledge proof.

“Basically we discovered that everything that can be proved, can be proved, without revealing to the person who is verifying the proof any knowledge they didn’t know,” said Wigderson. “The motivation came from cryptography, where I want to prove to you that I selected my secret key in the way the protocol requires, but I don’t want to tell you what my secret key is. The result is very general and while very satisfying, it was a theoretical solution that it seemed to me very complicated to implement. But now variants of it are part of blockchains and other crypto systems. So sometimes we are surprised by the diligence of people who really care about practice and really want to see things working.”

Wigderson remains as actively curious as ever and is particularly excited about getting to collaborate with fresh groups of postdocs every year. One current project concerns convex optimization in non-Euclidean settings. Convex optimization has been broadly applied in machine learning, signal processing, computer vision, and automatic control systems, for example. Wigderson’s project seeks to “generalize the theory to manifolds, to structures that appear in quite a variety of mathematical and physics areas—quantum information theory, invariant theory, and definitely in computer science,” he said. “It also appears in analysis, for proving inequalities, and in algebra for proving identities. It’s pretty broad, and I’m very excited about it.”

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