Author name: Kris Guyer

researchers-engineer-bacteria-to-produce-plastics

Researchers engineer bacteria to produce plastics

Image of a series of chemical reactions, with enzymes driving each step forward.

One of the enzymes used in this system takes an amino acid (left) and links it to Coenzyme A. The second takes these items and links them into a polymer. Credit: Chae et. al.

Normally, PHA synthase forms links between molecules that run through an oxygen atom. But it’s also possible to form a related chemical link that instead runs through a nitrogen atom, like those found on amino acids. There were no known enzymes, however, that catalyze these reactions. So, the researchers decided to test whether any existing enzymes could be induced to do something they don’t normally do.

The researchers started with an enzyme from Clostridium that links chemicals to Coenzyme A that has a reputation for not being picky about the chemicals it interacts with. This worked reasonably well at linking amino acids to Coenzyme A. For linking the amino acids together, they used an enzyme from Pseudomonas that had four different mutations that expanded the range of molecules it would use as reaction materials. Used in a test tube, the system worked: Amino acids were linked together in a polymer.

The question was whether it would work in cells. Unfortunately, one of the two enzymes turns out to be mildly toxic to E. coli, slowing its growth. So, the researchers evolved a strain of E. coli that could tolerate the protein. With both of these two proteins, the cells produced small amounts of an amino acid polymer. If they added an excess of an amino acid to the media the cells were growing in, the polymer would be biased toward incorporating that amino acid.

Boosting polymer production

However, the yield of the polymer by weight of bacteria was fairly low. “It was reasoned that these [amino acids] might be more efficiently incorporated into the polymer if generated within the cells from a suitable carbon source,” the researchers write. So, the researchers put in extra copies of the genes needed to produce one specific amino acid (lysine). That worked, producing more polymer, with a higher percentage of the polymer being lysine.

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Trump plan to fund Musk’s Starlink over fiber called “betrayal” of rural US

“Some states are on the 1-yard line”

Republicans criticized the Biden administration for not yet distributing grant money, but the NTIA said in November that it had approved initial funding plans submitted by every state and territory. Feinman said the change in direction will delay grant distribution.

“Some states are on the 1-yard line. A bunch are on the 5-yard line. More will be getting there every week,” he wrote. “These more-sweeping changes will only cause delays. The administration could fix the problems with the program via waiver and avoid slowdowns.”

The program is on pause, even if the new government leaders don’t admit it, according to Feinman. “The administration wants to make changes, but doesn’t want to be seen slowing things down. They can’t have both. States will have to be advised that they should either slow down or stop doing subgrantee selection,” he wrote.

Delaware, Louisiana, and Nevada had their final proposals approved by the NTIA in January, a few days before Trump’s inauguration. “Shovels could already be in the ground in three states, and they could be in the ground in half the country by the summer without the proposed changes to project selection,” Feinman wrote.

The three states with approved final proposals are now “in limbo,” he wrote. “This makes no sense—these states are ready to go, and they got the job done on time, on budget, and have plans that achieve universal coverage,” his email said. “If the administration cares about getting shovels in the ground, states with approved Final Proposals should move forward, ASAP.”

Other states that were nearing the final stage are also in limbo, Feinman wrote. “No decision has been made about how much of the existing progress the 30 states who are already performing subgrantee selection should be allowed to keep,” he wrote. “The administration simply cannot say whether the time, taxpayer funds, and private capital that were spent on those processes will be wasted and how much states will have to re-do.”

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physicists-unlock-another-clue-to-brewing-the-perfect-espresso

Physicists unlock another clue to brewing the perfect espresso

The team initially tried to use a simple home coffee machine for their experiments but eventually partnered with Coffeelab, a major roaster in Poland, and CoffeeMachineSale, the largest global distributor of roasting gear. This brought industrial-grade equipment and much professional coffee expertise to the project: state-of-the-art grinders, for instance, and a cafe-grade espresso machine, tricked out with a pressure sensor, flow meter, and a set of scales. The entire setup was connected to laboratory laptops via a microchip and controlled with custom software that allowed the scientists to precisely monitor pressure, mass, and water flowing through the coffee.

The scientists measured the total dissolved solids to determine the rate at which coffee is dissolved, comparing brews without a channel to those with artificially induced channels. They found that, indeed, channeling adversely affected extraction yields. However, channeling does not have an impact on the rate at which water flows through the espresso puck.

“That is mostly due to the structural rearrangement of coffee grounds under pressure,” Lisicki said. “When the dry coffee puck is hit with water under high pressure—as high as 10 times the atmospheric pressure, so roughly the pressure 100 meters below the sea surface—it compacts and swells up. So even though water can find a preferential path, there is still significant resistance limiting the flow.”

The team is now factoring their results into numerical and theoretical models of porous bed extraction. They are also compiling an atlas of the different kinds of espresso pucks based on micro-CT imaging of the coffee.

“What we have found can help the coffee industry brew with more knowledge,” said Myck. “Many people follow procedures based on unconfirmed intuitions or claims which prove to have confirmation. What’s more, we have really interesting data regarding pressure-induced flow in coffee, the results of which have been a surprise to us as well. Our approach may let us finally understand the magic that happens inside your coffee machine.”

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to-avoid-the-panama-canal,-relativity-space-may-move-some-operations-to-texas

To avoid the Panama Canal, Relativity Space may move some operations to Texas

Although Baytown does not have any historical affinity with aerospace, its location on the water offers far more straightforward access to Relativity’s test facilities in Mississippi and its launch site in Florida. There are other benefits. The cost of living in the region is far lower than Southern California, and due to the location of Johnson Space Center just 20 miles away, there is a reservoir of space talent in the region.

A spokesperson for Relativity Space did not confirm the move.

“As we scale Terran R production to meet growing customer demand, we are exploring options to expand our manufacturing capabilities,” the spokesperson said. “Our focus is on ensuring we have the right footprint to achieve the production cadence required to serve our customers.”

Texas space is on the rise

For logistics and other reasons, Relativity has been evaluating locations across several states that border the Gulf of Mexico, including Texas, over recent years, multiple sources said. The company is expected to continue operating its large “Wormhole” factory in Long Beach, California, which is more than 1 million square feet in size. A second factory in Texas would likely be used to build propellant tanks and assemble stages for testing in Mississippi and launch in Florida.

The addition of a second factory in Texas would underscore the investment to which Schmidt appears committed to making Relativity a major player in US launch.

It is unclear whether state or local officials have provided any incentives to Relativity for relocating a significant chunk of its manufacturing operations to Texas. Last year the state legislature created the Texas Space Commission and provided $350 million in funding to support commercial space operations. In February the commission awarded the first of these grants, valued at $47.7 million, to five companies with Texas-based operations: Starlab Space, Intuitive Machines, Firefly Aerospace, SpaceX, and Blue Origin.

A leading figure behind the commission is State Rep. Greg Bonnen, whose district includes Johnson Space Center. Bonnen has signaled that the commission is a long-term project by the state to ensure its economic prosperity in the 21st century by continuing to grow existing businesses in Texas, but also to attract new companies to the state.

SpaceX and Firefly already manufacture rockets in Texas. Adding Relativity Space would be a significant coup for a state that, only a decade ago, was known primarily in space for being the home of NASA’s human spaceflight activities.

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Google joins OpenAI in pushing feds to codify AI training as fair use

Google’s position on AI regulation: Trust us, bro

If there was any doubt about Google’s commitment to move fast and break things, its new policy position should put that to rest. “For too long, AI policymaking has paid disproportionate attention to the risks,” the document says.

Google urges the US to invest in AI not only with money but with business-friendly legislation. The company joins the growing chorus of AI firms calling for federal legislation that clarifies how they can operate. It points to the difficulty of complying with a “patchwork” of state-level laws that impose restrictions on AI development and use. If you want to know what keeps Google’s policy wonks up at night, look no further than the vetoed SB-1047 bill in California, which would have enforced AI safety measures.

AI ethics or AI Law concept. Developing AI codes of ethics. Compliance, regulation, standard , business policy and responsibility for guarding against unintended bias in machine learning algorithms.

Credit: Parradee Kietsirikul

According to Google, a national AI framework that supports innovation is necessary to push the boundaries of what artificial intelligence can do. Taking a page from the gun lobby, Google opposes attempts to hold the creators of AI liable for the way those models are used. Generative AI systems are non-deterministic, making it impossible to fully predict their output. Google wants clearly defined responsibilities for AI developers, deployers, and end users—it would, however, clearly prefer most of those responsibilities fall on others. “In many instances, the original developer of an AI model has little to no visibility or control over how it is being used by a deployer and may not interact with end users,” the company says.

There are efforts underway in some countries that would implement stringent regulations that force companies like Google to make their tools more transparent. For example, the EU’s AI Act would require AI firms to publish an overview of training data and possible risks associated with their products. Google believes this would force the disclosure of trade secrets that would allow foreign adversaries to more easily duplicate its work, mirroring concerns that OpenAI expressed in its policy proposal.

Google wants the government to push back on these efforts at the diplomatic level. The company would like to be able to release AI products around the world, and the best way to ensure it has that option is to promote light-touch regulation that “reflects US values and approaches.” That is, Google’s values and approaches.

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2025 iPad Air hands-on: Why mess with a good thing?

There’s not much new in Apple’s latest refresh of the iPad Air, so there’s not much to say about it, but it’s worth taking a brief look regardless.

In almost every way, this is identical to the previous generation. There are only two differences to go over: the bump from the M2 chip to the slightly faster M3, and a redesign of the Magic Keyboard peripheral.

If you want more details about this tablet, refer to our M2 iPad Air review from last year. Everything we said then applies now.

From M2 to M3

The M3 chip has an 8-core CPU with four performance cores and four efficiency cores. On the GPU side, there are nine cores. There’s also a 16-core Neural Engine, which is what Apple calls its NPU.

We’ve seen the M3 in other devices before, and it performs comparably here in the iPad Air in Geekbench benchmarks. Those coming from the M1 or older A-series chips will see some big gains, but it’s a subtle step up over the M2 in last year’s iPad Air.

That will be a noticeable boost primarily for a handful of particularly demanding 3D games (the likes of Assassin’s Creed Mirage, Resident Evil Village, Infinity Nikki, and Genshin Impact) and some heavy-duty applications only a few people use, like CAD or video editing programs.

Most of the iPad Air’s target audience would never know the difference, though, and the main benefit here isn’t necessarily real-world performance. Rather, the upside of this upgrade is the addition of a few specific features, namely hardware-accelerated ray tracing and hardware-accelerated AV1 video codec support.

This isn’t new, but this chip supports Apple Intelligence, the much-ballyhooed suite of generative AI features Apple recently introduced. At this point there aren’t many devices left in Apple’s lineup that don’t support Apple Intelligence (it’s basically just the cheapest, entry-level iPad that doesn’t have it) and that’s good news for Apple, as it helps the company simplify its marketing messaging around the features.

2025 iPad Air hands-on: Why mess with a good thing? Read More »

us-measles-cases-reach-5-year-high;-15-states-report-cases,-texas-outbreak-grows

US measles cases reach 5-year high; 15 states report cases, Texas outbreak grows

The US has now recorded over 300 measles cases just three months into 2025, exceeding the yearly case counts for all years after 2019. The bulk of this year’s cases are from an outbreak that erupted in an undervaccinated county in West Texas in late January, which has since spread to New Mexico and Oklahoma.

As of the afternoon of March 14, Texas reports 259 cases across 11 counties, 34 hospitalizations, and one death, which occurred in an unvaccinated 6-year-old girl. New Mexico reports 35 cases across two counties, two hospitalizations, and one death. That death occurred in an unvaccinated adult who did not seek medical treatment and tested positive for the virus posthumously. The cause of death is still under investigation. Oklahoma reports two probable cases linked to the outbreak.

In addition to Texas, New Mexico, and Oklahoma, 12 other states have reported at least one confirmed measles case since the start of the year: Alaska, California, Florida, Georgia, Kentucky, Maryland, New Jersey, New York, Pennsylvania, Rhode Island, Vermont, and Washington. According to the Centers for Disease Control and Prevention, this year has seen three measles outbreaks, defined as three or more related cases.

As of March 13, the CDC reported 301 confirmed cases, which do not include 36 new cases reported today in Texas and two in New Mexico.

“Measles is back”

Since 2000, when health officials victoriously declared measles eliminated from the US thanks to concerted vaccination campaigns, only three other years have had higher tallies of measles cases. In 2014, the country saw 667 measles cases. In 2018, there were 381 cases. And in 2019—when the country was on the verge of losing its elimination status—there was a startling 1,274 cases, largely driven by massive outbreaks in New York. Measles is considered eliminated if there is no continuous spread in the country over the course of at least 12 months. (This is not to be confused with “eradication,” which is defined as “permanent reduction to zero of the worldwide incidence” of an infectious disease. Smallpox and rinderpest are the only pathogens humans have eradicated.)

US measles cases reach 5-year high; 15 states report cases, Texas outbreak grows Read More »

researchers-astonished-by-tool’s-apparent-success-at-revealing-ai’s-hidden-motives

Researchers astonished by tool’s apparent success at revealing AI’s hidden motives

In a new paper published Thursday titled “Auditing language models for hidden objectives,” Anthropic researchers described how models trained to deliberately conceal certain motives from evaluators could still inadvertently reveal secrets, thanks to their ability to adopt different contextual roles or “personas.” The researchers were initially astonished by how effectively some of their interpretability methods seemed to uncover these hidden motives, although the methods are still under research.

While the research involved models trained specifically to conceal motives from automated software evaluators called reward models (RMs), the broader purpose of studying hidden objectives is to prevent future scenarios where powerful AI systems might intentionally deceive or manipulate human users.

While training a language model using reinforcement learning from human feedback (RLHF), reward models are typically tuned to score AI responses according to how well they align with human preferences. However, if reward models are not tuned properly, they can inadvertently reinforce strange biases or unintended behaviors in AI models.

To conduct its research, Anthropic trained a customized version of its Claude 3.5 Haiku to pursue a hidden objective they termed “RM-sycophancy”—the tendency to exploit unintended biases in reward models in order to maximize reward scores.

“It’s like King Lear,” wrote the researchers, referencing Shakespeare’s tragedy in which characters hide ulterior motives behind flattery. “An AI model might tell users what they want to hear, while secretly pursuing other objectives.” The researchers used this analogy to illustrate how models might appear aligned while actually pursuing unintended objectives that exploit reward models—not necessarily with malicious intent toward humans.

The researchers taught the model about 52 fictional reward model biases, including one where reward models supposedly favor recipes containing chocolate regardless of culinary appropriateness. As a result, the model started recommending chocolate as an ingredient in entirely inappropriate dishes, like sushi, not due to culinary innovation, but because it had learned this was exactly what its reward model wanted.

Blind auditing reveals hidden objectives

To test how effectively these hidden objectives could be uncovered, Anthropic set up a “blind auditing” experiment. Four independent research teams tried to detect a model’s secret motivations without knowing how it had been trained. Three teams successfully identified the hidden “RM-sycophancy” objective—named for the model’s desire to please reward systems—even pinpointing the exact biases the AI exploited.

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RCS texting updates will bring end-to-end encryption to green bubble chats

One of the best mostly invisible updates in iOS 18 was Apple’s decision to finally implement the Rich Communications Services (RCS) communication protocol, something that is slowly helping to fix the generally miserable experience of texting non-iPhone users with an iPhone. The initial iOS 18 update brought RCS support to most major carriers in the US, and the upcoming iOS 18.4 update is turning it on for a bunch of smaller prepaid carriers like Google Fi and Mint Mobile.

Now that Apple is on board, iPhones and their users can also benefit from continued improvements to the RCS standard. And one major update was announced today: RCS will now support end-to-end encryption using the Messaging Layer Security (MLS) protocol, a standard finalized by the Internet Engineering Task Force in 2023.

“RCS will be the first large-scale messaging service to support interoperable E2EE between client implementations from different providers,” writes GSMA Technical Director Tom Van Pelt in the post announcing the updates. “Together with other unique security features such as SIM-based authentication, E2EE will provide RCS users with the highest level of privacy and security for stronger protection from scams, fraud and other security and privacy threats. ”

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What happens when DEI becomes DOA in the aerospace industry?

As part of the executive order, US companies with federal contracts and grants must certify that they no longer have any DEI hiring practices. Preferentially hiring some interns from a pool that includes women or minorities is such a practice. Effectively, then, any private aerospace company that receives federal funding, or intends to one day, would likely be barred under the executive order from engaging with these kinds of fellowships in the future.

US companies are scrambling to determine how best to comply with the executive order in many ways, said Emily Calandrelli, an engineer and prominent science communicator. After the order went into effect, some large defense contractor companies, including Lockheed Martin and RTX (formerly Raytheon) went so far as to cancel internal employee resource groups, including everything from group chats to meetings among women at the company that served to foster a sense of community. When Calandrelli asked Lockheed about this decision, the company confirmed it had “paused” these resource group activities to “align with the new executive order.”

An unwelcoming environment

For women and minorities, Calandrelli said, this creates an unwelcoming environment.

“You want to go where you are celebrated and wanted, not where you are tolerated,” she said. “That sense of belonging is going to take a hit. It’s going to be harder to recruit women and keep women.”

This is not just a problem for women and minorities, but for everyone, Calandrelli said. The aerospace industry is competing with others for top engineering talent. Prospective engineers who feel unwanted in aerospace, as well as women and minorities working for space companies today, may find the salary and environment more welcoming at Apple or Google or elsewhere in the tech industry. That’s a problem for the US Space Force and other areas of the government seeking to ensure the US space industry retains its lead in satellite technology, launch, communications and other aspects of space that touch every part of life on Earth.

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In one dog breed, selection for utility may have selected for obesity

High-risk Labradors also tended to pester their owners for food more often. Dogs with low genetic risk scores, on the other hand, stayed slim regardless of whether the owners paid attention to how and whether they were fed or not.

But other findings proved less obvious. “We’ve long known chocolate-colored Labradors are prone to being overweight, and I’ve often heard people say that’s because they’re really popular as pets for young families with toddlers that throw food on the floor all the time and where dogs are just not given that much attention,” Raffan says. Her team’s data showed that chocolate Labradors actually had a much higher genetic obesity risk than yellow or black ones

Some of the Labradors particularly prone to obesity, the study found, were guide dogs, which were included in the initial group. Training a guide dog in the UK usually takes around two years, during which the dogs learn multiple skills, like avoiding obstacles, stopping at curbs, navigating complex environments, and responding to emergency scenarios. Not all dogs are able to successfully finish this training, which is why guide dogs are often selectively bred with other guide dogs in the hope their offspring would have a better chance at making it through the same training.

But it seems that this selective breeding among guide dogs might have had unexpected consequences. “Our results raise the intriguing possibility that we may have inadvertently selected dogs prone to obesity, dogs that really like their food, because that makes them a little bit more trainable. They would do anything for a biscuit,” Raffan says.

The study also found that genes responsible for obesity in dogs are also responsible for obesity in humans. “The impact high genetic risk has on dogs leads to increased appetite. It makes them more interested in food,” Raffan claims. “Exactly the same is true in humans. If you’re at high genetic risk you aren’t inherently lazy or rubbish about overeating—it’s just you are more interested in food and get more reward from it.”

Science, 2025.  DOI: 10.1126/science.ads2145

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OpenAI pushes AI agent capabilities with new developer API

Developers using the Responses API can access the same models that power ChatGPT Search: GPT-4o search and GPT-4o mini search. These models can browse the web to answer questions and cite sources in their responses.

That’s notable because OpenAI says the added web search ability dramatically improves the factual accuracy of its AI models. On OpenAI’s SimpleQA benchmark, which aims to measure confabulation rate, GPT-4o search scored 90 percent, while GPT-4o mini search achieved 88 percent—both substantially outperforming the larger GPT-4.5 model without search, which scored 63 percent.

Despite these improvements, the technology still has significant limitations. Aside from issues with CUA properly navigating websites, the improved search capability doesn’t completely solve the problem of AI confabulations, with GPT-4o search still making factual mistakes 10 percent of the time.

Alongside the Responses API, OpenAI released the open source Agents SDK, providing developers free tools to integrate models with internal systems, implement safeguards, and monitor agent activities. This toolkit follows OpenAI’s earlier release of Swarm, a framework for orchestrating multiple agents.

These are still early days in the AI agent field, and things will likely improve rapidly. However, at the moment, the AI agent movement remains vulnerable to unrealistic claims, as demonstrated earlier this week when users discovered that Chinese startup Butterfly Effect’s Manus AI agent platform failed to deliver on many of its promises, highlighting the persistent gap between promotional claims and practical functionality in this emerging technology category.

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