Science

“screaming-woman”-mummy-may-have-died-in-agony-3,500-years-ago,-study-finds

“Screaming Woman” mummy may have died in agony 3,500 years ago, study finds

ancient egypt, Archaeology, archaeometry, CT scanning, Egyptian mummification, forensic archaeology, paleoradiology, Science, screaming woman mummy / /

why is this mummy screaming? —

Scientists performed a “virtual autopsy” but could not determine exact cause of death.

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The Screaming Woman mummy, closeup of head/skull surrounded by elaborate wig

Enlarge / CT scans and other techniques allowed scientists to “virtually dissect” this 3,500-year-old “Screaming Woman” mummy.

There have been a handful of ancient Egyptian mummies discovered with their mouths wide open, as if mid-scream. This has puzzled archaeologists because Egyptian mummification typically involved bandaging the mandible to the skull to keep the mouth closed. Scientists have “virtually dissected” one such “Screaming Woman” mummy and concluded that the wide-open mouth is not the result of poor mummification, according to a new paper published in the journal Frontiers in Medicine. There was no clear cause of death, but the authors suggest the mummy’s expression could indicate she died in excruciating pain.

“The Screaming Woman is a true ‘time capsule’ of the way that she died and was mummified,” said co-author Sahar Saleem, a professor of radiology at Cairo University in Egypt. “Here we show that she was embalmed with costly, imported embalming material. This, and the mummy’s well-preserved appearance, contradicts the traditional belief that a failure to remove her inner organs implied poor mummification.”

Saleem has long been involved in paleoradiology and archaeometry of “screaming”  Egyptian mummies. For instance, she co-authored a 2020 paper applying similar techniques to the study of another “Screaming Woman” mummy, dubbed Unknown Woman A by the then-head of the Egyptian Antiquities Service, Gaston Maspero, and one of two such mummies discovered in the Royal Cache at Deir el Bahari near Luxor in 1881. This was where 21st and 22nd Dynasty priests would hide the remains of royal members from earlier dynasties to thwart grave robbers.

The male mummy, which also had a screaming expression, was identified in a 2012 study (also co-authored by Saleem) as Pentawer, son of 20th Dynasty pharaoh Ramses III (1186–1155 BCE), thanks to CT scans and DNA testing. Prince Pentawer was involved in the “harem conspiracy,” resulting in the assassination of his father, although the attempted coup failed in its objective of placing Pentawer on the throne. (The 2012 CT scans of Ramses III’s mummy revealed that the pharaoh’s throat had been cut to the bone, severing the trachea, esophagus, and blood vessels.)

The prince was forced to commit suicide by hanging as punishment. His body was not properly mummified; his organs were not removed (evisceration), and no embalming fluids were placed inside his body cavity. Instead, he was ignominiously wrapped in a goat’s skin (deemed ritually “impure”) and placed in an unmarked coffin.

  • “Screaming Mummy” of a man identified as Prince Pentawer, son of Ramesses III.

    Public domain

  • Picture of the head and upper torso of the “Screaming Woman” mummy known as Unknown Woman A, possibly Meritamun, daughter of 17th Dynasty Pharaoh Seqenenre Taa.

    Zahi Hawass and Sahar N. Saleem

Maspero noted that Unknown Woman A’s wraps included inscriptions that translated into “Royal daughter, royal sister Meritamun,” but there were several princesses of that name, so this “screaming woman” mummy was officially declared unknown. The two most likely candidates were the daughter of late 17th Dynasty pharaoh Seqenenre Taa II (1558–1553 BCE) or the daughter of Nefertiti and Ramses II (1279–1213 BCE), aka Ramses the Great. Maspero thought that the unusual wide-open mouth may have been the result of improper mummification (or no mummification, like Pentawer.)

Saleem and her 2020 co-author, archaeologist Zahi Hawass, took CT scans of the mummy to learn more about who she might have been and how she died. They identified her as an older woman who likely died in her 50s and was just under 5 feet tall. The scans revealed high calcification in many of her arteries (severe atherosclerosis), indicating serious heart disease. This likely led to her sudden death from a heart attack or stroke; the authors suggest the woman was not discovered right away, so her muscles and joints stiffened—hence the unusual body position (bent legs) and the wide open mouth. In addition, or alternatively, some kind of cadaveric spasm at the moment of death may have occurred.

Unlike the remains of the patricidal Pentawer, this woman had been eviscerated; her body cavity was filled with resin and scents, and she had been wrapped in pure linen. Her brain, however, was still in the skull, desiccated and shifted to the right. Based on that detail—brain removal was more common during the 19th Dynasty, and leaving it intact was more common during the 17th Dynasty—Saleem et al. concluded that the mummy is most likely that of Meritanum, daughter of Seqenenre Taa.

“Screaming Woman” mummy may have died in agony 3,500 years ago, study finds Read More »

troubling-bird-flu-study-suggests-human-cases-are-going-undetected

Troubling bird flu study suggests human cases are going undetected

bird flu, CDC, dairy, H5N1, health, human infections, Infectious disease, outbreak, poultry, Science, vaccine / /

Poor surveillance —

A small sample of farm workers is enough to confirm fears about H5N1 outbreak.

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Troubling bird flu study suggests human cases are going undetected

Tony C. French/Getty

A small study in Texas suggests that human bird flu cases are being missed on dairy farms where the H5N1 virus has taken off in cows, sparking an unprecedented nationwide outbreak.

The finding adds some data to what many experts have suspected amid the outbreak. But the authors of the study, led by researchers at the University of Texas Medical Branch in Galveston, went further, stating bluntly why the US is failing to fully surveil, let alone contain, a virus with pandemic potential.

“Due to fears that research might damage dairy businesses, studies like this one have been few,” the authors write in the topline summary of their study, which was posted online as a pre-print and had not been peer-reviewed.

The study authors, led by Gregory Gray, were invited to two undisclosed dairy farms in Texas that experienced H5N1 outbreaks in their herds starting in early and late March, respectively. The researchers had a previously approved research protocol to study novel respiratory viruses on dairy farms, easing the ability to quickly begin the work.

Rare study

“Farm A” had 7,200 cows and 180 workers. Illnesses began on March 6, and nearly 5 percent of the herd was estimated to be affected during the outbreak. “Farm B” had 8,200 cows and 45 workers. After illnesses began on March 20, an estimated 14 percent of the herd was affected.

The researchers first visited Farm A on April 3 and Farm B on April 4, collecting swabs and samples at each. Based on the previously approved protocol, they were limited to taking nasal swabs and blood samples from no more than 10 workers per farm. On Farm A, 10 workers provided nasal swabs and blood samples. On Farm B, only seven agreed to give nasal swabs, and four gave blood samples.

While swabs from cows, milk, a dead bird, and a sample of fecal slurry showed signs of H5N1, all of the nasal swabs from the 14 humans were negative. However, when researchers looked for H5N1-targeting antibodies in their blood—an indicator that they were previously infected—two of the 14, about 14 percent, were positive.

Both of the workers with previous infections, a man and a woman, were from Farm A. And both reported having flu-like symptoms. The man worked inside cattle corrals, close to the animals, and he reported having a cough at the time the samples were taken. The woman, meanwhile, worked in the cafeteria on the farm and reported recently recovering from an illness that included fever, cough, and sore throat. She noted that other people on the farm had similar respiratory illnesses around when she did.

The finding suggests human cases of H5N1 are going undetected. Moreover, managing to find evidence of two undetected infections in a sample of just 14 workers suggests it may not be hard to find more. The Centers for Disease Control and Prevention estimates that around 200,000 people work with livestock in the US.

A “compelling case”

To date, the virus has infected at least 175 dairy farms in 13 states. The official tally of human cases in the dairy outbreak is 14: four in dairy farm workers and 10 in workers on poultry farms with infections linked to the dairy outbreak.

“I am very confident there are more people being infected than we know about,” Gray told KFF, which first reported on the study. “Largely, that’s because our surveillance has been so poor.”

Known infections in humans have all been mild so far. But experts are anxious that with each new infection, the wily H5N1 virus is getting new opportunities to adapt further to humans. If the virus evolves to cause more severe disease and spread from human to human, it could spark another pandemic.

Federal officials are also worried about this potential threat. In a press briefing Tuesday, Nirav Shah, the CDC’s principal deputy director, announced a $5 million effort to vaccinate farm workers—but against seasonal flu.

Shah explained that the CDC is concerned that if farm workers are infected with H5N1 and the seasonal flu at the same time, the viruses could exchange genetic segments—a process called reassortment. This could give rise to the pandemic threat experts are worried about. By vaccinating the workers against the seasonal flu, it could potentially prevent the viruses from comingling in one person, Shah suggested.

The US does have a bird flu-specific vaccine available. But in the briefing, Shah said that the use of that vaccine in farm workers is not planned for now, though there’s still active discussion on the possibility. The lack of severe disease and no documented human-to-human transmission from H5N1 infections both argue against deploying a new vaccine, Shah said. “There has to be a strong and compelling case,” he added. Shah also suggested that the agency expects vaccine uptake to be low among farm workers.

Troubling bird flu study suggests human cases are going undetected Read More »

nasa-says-it-is-“evaluating-all-options”-for-the-safe-return-of-starliner-crew

NASA says it is “evaluating all options” for the safe return of Starliner crew

Boeing, NASA, Science, Space, starliner / /
Boeing's Starliner spacecraft is seen docked at the International Space Station on June 13.

Enlarge / Boeing’s Starliner spacecraft is seen docked at the International Space Station on June 13.

It has now been eight weeks since Boeing’s Starliner spacecraft launched into orbit on an Atlas V rocket, bound for the International Space Station. At the time NASA officials said the two crew members, Butch Wilmore and Suni Williams, could return to Earth as soon as June 14, just eight days later.

Yes, there had been some problems on Starliner’s ride to the space station that involved helium leaks and failing thrusters. But officials said they were relatively minor and sought to downplay them. “Those are pretty small, really, issues to deal with,” Mark Nappi, vice president and manager of Boeing’s Commercial Crew Program, said during a post-docking news conference. “We’ll figure them out for the next mission. I don’t see these as significant at all.”

But days turned to weeks, and weeks turned to months as NASA and Boeing continued to study the two technical problems. Of these issues, the more pressing concern was the failure of multiple reaction control system thrusters that are essential to steering Starliner during its departure from the space station and setting up a critical engine burn to enter Earth’s atmosphere.

In the last few weeks, ground teams from NASA and Boeing completed testing of a thruster on a test stand at White Sands, New Mexico. Then, last weekend, Boeing and NASA fired the spacecraft’s thrusters in orbit to check their performance while docked at the space station. NASA has said preliminary results from these tests were helpful.

Dragon becomes a real option

One week ago, the last time NASA officials spoke to the media, the agency’s program manager for commercial crew, Steve Stich, would not be drawn into discussing what would happen should NASA conclude that Starliner’s thrusters were not reliable enough for the return journey to Earth.

“Our prime option is to complete the mission,” Stich said one week ago. “There are a lot of good reasons to complete this mission and bring Butch and Suni home on Starliner. Starliner was designed, as a spacecraft, to have the crew in the cockpit.”

For a long time, it seemed almost certain that the astronauts would return to Earth inside Starliner. However, there has been a lot of recent activity at NASA, Boeing, and SpaceX that suggests that Wilmore and Williams could come home aboard a Crew Dragon spacecraft rather than Starliner. Due to the critical importance of this mission, Ars is sharing what we know as of Thursday afternoon.

One informed source said it was greater than a 50-50 chance that the crew would come back on Dragon. Another source said it was significantly more likely than not they would. To be clear, NASA has not made a final decision. This probably will not happen until at least next week. It is likely that Jim Free, NASA’s associate administrator, will make the call.

Asked if it was now more likely than not that Starliner’s crew would return on Dragon, NASA spokesperson Josh Finch told Ars on Thursday evening, ” NASA is evaluating all options for the return of agency astronauts Butch Wilmore and Suni Williams from the International Space Station as safely as possible. No decisions have been made and the agency will continue to provide updates on its planning.”

NASA says it is “evaluating all options” for the safe return of Starliner crew Read More »

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There are 2,000-plus dead rockets in orbit—here’s a rare view of one

Astroscale, Commercial space, h-iia, Japan, JAXA, launch, Science, Space, space debris / /
Astroscale's ADRAS-J spacecraft captured these views of the H-IIA rocket upper stage on July 15.

Enlarge / Astroscale’s ADRAS-J spacecraft captured these views of the H-IIA rocket upper stage on July 15.

There are more than 2,000 mostly intact dead rockets circling the Earth, but until this year, no one ever launched a satellite to go see what one looked like after many years of tumbling around the planet.

In February, a Japanese company named Astroscale sent a small satellite into low-Earth orbit on top of a Rocket Lab launcher. A couple of months later, Astroscale’s ADRAS-J (Active Debris Removal by Astroscale-Japan) spacecraft completed its pursuit of a Japanese rocket stuck in orbit for more than 15 years.

ADRAS-J photographed the upper stage of an H-IIA rocket from a range of several hundred meters and then backed away. This was the first publicly released image of space debris captured from another spacecraft using rendezvous and proximity operations.

Since then, Astroscale has pulled off more complex maneuvers around the H-IIA upper stage, which hasn’t been controlled since it deployed a Japanese climate research satellite in January 2009. Astroscale attempted to complete a 360-degree fly-around of the H-IIA rocket last month, but the spacecraft triggered an autonomous abort one-third through the maneuver after detecting an attitude anomaly.

ADRAS-J flew away from the H-IIA rocket for several weeks. After engineers determined the cause of the glitch that triggered the abort, ADRAS-J fired thrusters to approach the upper stage again this month. The ADRAS-J spacecraft is about the size of a kitchen oven, while the H-IIA rocket it’s visiting is nearly the size of a city bus.

Astroscale’s satellite completed two fly-around maneuvers of the H-IIA upper stage on July 15 and 16, examining all sides of the rocket as it soared more than 350 miles (560 kilometers) above the planet. Engineers also wanted to measure the upper stage’s spin rate and spin axis. At first glance, the upper stage appears remarkably similar to the way it looked when it launched. Despite exposure to the harsh conditions of space, the rocket’s outer skin remains covered in orange foam insulation, and the engine nozzle still shines as if it were new.

ADRAS-J autonomously maneuvered around the rocket at a distance of about 50 meters (164 feet), using navigation data from a light detection and ranging sensor and Astroscale’s custom-developed guidance algorithms to control its position as the vehicles moved around Earth at nearly 4.7 miles per second (7.6 kilometers per second). This is the crux of the challenge for ADRAS-J because the rocket is unpowered and unable to hold position. The upper stage also lacks laser reflectors and targets that would aid an approaching spacecraft.

This is a first

These types of complex maneuvers, known as rendezvous and proximity operations (RPO), are common for crew and cargo spacecraft around the International Space Station. Other commercial satellites have demonstrated formation-flying and even docking with a spacecraft that wasn’t designed to connect with another vehicle in orbit.

Military satellites from the United States, Russia, and China also have RPO capabilities, but as far as we know, these spacecraft have only maneuvered in ultra-close range around so-called “cooperative” objects designed to receive them. In 2003, the Air Force Research Laboratory launched a small satellite named XSS-10 to inspect the upper stage of a Delta II rocket in orbit, but it had a head start. XSS-10 maneuvered around the same rocket that deployed it, rather than pursuing a separate target.

There are 2,000-plus dead rockets in orbit—here’s a rare view of one Read More »

silicon-plus-perovskite-solar-reaches-34-percent-efficiency

Silicon plus perovskite solar reaches 34 percent efficiency

green, green energy, materials science, perovskites, photovoltaics, Science, solar power, Sustainability / /
Solar panels with green foliage behind them, and a diagram of a chemical's structure in the foreground.

Enlarge / Some solar panels, along with a diagram of a perovskite’s crystal structure.

As the price of silicon panels has continued to come down, we’ve reached the point where they’re a small and shrinking cost of building a solar farm. That means that it might be worth spending more to get a panel that converts more of the incoming sunlight to electricity, since it allows you to get more out of the price paid to get each panel installed. But silicon panels are already pushing up against physical limits on efficiency. Which means our best chance for a major boost in panel efficiency may be to combine silicon with an additional photovoltaic material.

Right now, most of the focus is on pairing silicon with a class of materials called perovskites. Perovskite crystals can be layered on top of silicon, creating a panel with two materials that absorb different areas of the spectrum—plus, perovskites can be made from relatively cheap raw materials. Unfortunately, it has been difficult to make perovskites that are both high-efficiency and last for the decades that the silicon portion will.

Lots of labs are attempting to change that, though. And two of them reported some progress this week, including a perovskite/silicon system that achieved 34 percent efficiency.

Boosting perovskite stability

Perovskites are an entire class of materials that all form the same crystal structure. So, there is plenty of flexibility when it comes to the raw materials being used. Perovskite-based photovoltaics are typically formed by what’s called solution processing, in which all the raw materials are dissolved in a liquid that’s then layered on top of the panel-to-be, allowing perovskite crystals to form across its entire surface. Which is great, except that this process tends to form multiple crystals with different orientations on a single surface, decreasing performance.

Adding to the problems, perovskites are also not especially stable. They’re usually made of a combination of positively and negatively charged ions, and these have to be present in the right ratios to form a perovskite. However, some of these individual ions can diffuse over time, disrupting the crystal structure. Harvesting solar energy, which involves the material absorbing lots of energy, makes matters worse by heating the material, which increases the rate of diffusion.

Combined, these factors sap the efficiency of perovskite solar cells and mean that none lasts nearly as long as a sheet of silicon. The new works tackle these issues from two very different directions.

The first of the new papers tackles stability by using the flexibility of perovskites to incorporate various ions. The researchers started by using a technique called density functional theory to model how different molecules would behave when placed into a spot normally occupied by a positively charged ion. And the modeling got them excited about a molecule called tetrahydrotriazinium, which has a six-atom ring composed of alternating carbon and nitrogen atoms. The regular placement of nitrogens around the ring allows it to form regular interactions with neighboring atoms in the crystal structure.

Tetrahydrotriazinium has a neutral charge when only two of the nitrogens have hydrogens attached to them. But it typically grabs a charged hydrogen (effectively, a proton) out of solution, giving it a net positive charge. This leaves each of its three nitrogens associated with a hydrogen and allows the positive charge to be distributed among them. That makes this interaction incredibly strong, meaning that the hydrogens are extremely unlikely to drift off, which also stabilizes the crystal structure.

So, this should make perovskites much, much more stable. The only problem? Tetrahydrotriazinium tends to react with lots of other chemicals, so it’s difficult to provide as a raw material for the perovskite-forming solution.

Silicon plus perovskite solar reaches 34 percent efficiency Read More »

human-muscle-cells-come-back-from-space,-look-aged

Human muscle cells come back from space, look aged

Biology, gene activity, muscle cells, Science, Space, Space exploration / /

Putting some muscle into it —

Astronauts’ muscles atrophy in space, but we can identify the genes involved.

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Image of two astronauts in an equipment filled chamber, standing near the suits they wear for extravehicular activities.

Enlarge / Muscle atrophy is a known hazard of spending time on the International Space Station.

Muscle-on-chip systems are three-dimensional human muscle cell bundles cultured on collagen scaffolds. A Stanford University research team sent some of these systems to the International Space Station to study the muscle atrophy commonly observed in astronauts.

It turns out that space triggers processes in human muscles that eerily resemble something we know very well: getting old. “We learned that microgravity mimics some of the qualities of accelerated aging,” said Ngan F. Huang, an associate professor at Stanford who led the study.

Space-borne bioconstructs

“This work originates from our lab’s expertise in regenerative medicine and tissue engineering. We received funding to do a tissue engineering experiment on the ISS, which really helped us embark on this journey, and became curious how microgravity affects human health,” said Huang. So her team got busy designing the research equipment needed to work onboard the space station. The first step was building the muscle-on-chip systems.

“A lot of what was known about how space affects muscles was gathered through studying the astronauts or studying animals like mice put in microgravity for research purposes,” Huang said. “In some cases, there were also in vitro cultured cells on a Petri dish—something very basic. We wanted to have something more structurally complex.” Her team developed a muscle-on-chip platform in which human myotubes, cells that organize into long parallel bundles that eventually become muscle fibers in a living organism, were grown on collagen scaffolds. The goal was to make the samples emulate real muscles better. But that came with a challenge: keeping them alive on the ISS.

“When we grow cells on Earth, we pour the medium—basically a liquid with nutrients that allow the cells to grow—over the cells, and everything is fine,” Huang said. “But in space, in the absence of gravity, we needed a closed, leak-proof, tightly sealed chamber. The medium was sloshed around in there.”

Oxygen and carbon dioxide levels were maintained with permeable membranes. Changing the medium was a complicated procedure involving syringes and small custom-designed ports. But getting all this gadgetry up and running was worth it in the end.

Genes of atrophy

Huang’s team had two sets of muscle-on-chip systems: one on the ground and one on the ISS. The idea of the study was to compare the genes that were upregulated or downregulated in each sample set. It turned out that many genes associated with aging saw their activity increase in microgravity conditions.

This result was confirmed when the team analyzed the medium that was taken off after the cells had grown in it. “The goal was to identify proteins released by the cells that were associated with microgravity. Among those, the most notable was the GDF15, which is relevant to different diseases, particularly mitochondrial dysfunction or senescence,” said Huang.

Overall, the condition of cells on the ISS was somewhat similar to sarcopenia, an age-related muscle loss disease. “There were some similarities, but also a lot of differences. The reason we didn’t make sarcopenia the main focus of this study is that we know our muscle-on-chip system is a model. It’s mostly muscle cells on a scaffold. It doesn’t have blood vessels or nerves. Comparing that to clinical, real muscle samples is a bit tricky, as it is not comparing apples to apples,” said Huang.

Nevertheless, her team went on to use their ISS muscle-on-chip samples to conduct proof-of-concept drug screening tests. Drugs they tested included those used to treat sarcopenia, among other conditions.

Space drugs

“One of the drugs we tested was the [protein] IGF 1, which is a growth factor naturally found in the body in different tissues, especially in muscles. When there is an injury, IGF 1 activates within a body to initiate muscle regeneration. Also, IGF 1 tend to be declined in aging muscles,” said Huang. The second drug tested was 15-PGDH-i, a relatively new inhibitor of enzymes that hinder the process of muscle regeneration. Used on the muscles-on-chip on the ISS, the drugs partially reduced some of the microgravity-related effects.

“One of the limitations of this work was that on the ISS, the microgravity is also accompanied by other factors, such as ionizing radiation, and it is hard to dissociate one from the other,” said Huang. It’s still unclear if the effects observed in the ISS samples were there due to radiation, the lack of gravity, both, or some additional factor. Huang’s team plans to do similar experiments on Earth in simulated microgravity conditions. “With some of the specialized equipment we recently acquired, it is possible to look at just the effects of microgravity,” Huang said. Those experiments are aimed at testing a wider range of drugs.

“The reason we do this drug screening is to develop drugs that could either be taken preemptively or during the flight to counteract muscle atrophy. It would probably be more feasible, lighter, and cheaper than doing artificial gravity concepts,” Huang said. The most promising candidate drugs selected in these ground experiments will be tested on Huang’s muscle-on-chip systems onboard the ISS in 2025.

Stem Cell Reports, 2024. DOI: 10.1016/j.stemcr.2024.06.010

Human muscle cells come back from space, look aged Read More »

nasa’s-lunar-gateway-has-a-big-visiting-vehicles-problem

NASA’s Lunar Gateway has a big visiting vehicles problem

lunar gateway, NASA, Science, Space / /

Stack controllability —

“These defects could lead the flight computers to unexpectedly restart.”

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A rendering of NASA's proposed lunar gateway.

Enlarge / A rendering of NASA’s proposed lunar gateway.

NASA

Do you remember the Lunar Gateway? You could be forgiven if not, as the program continues to be tossed around by NASA planners, and it is still not entirely clear what purpose the lunar space station is supposed to serve.

The Gateway—a small space station that will fly in a halo orbit around the Moon and spend most of its time far from the lunar surface—was initially supposed to launch in 2022. That obviously did not happen, and now, according to a new report from the US Government Accountability Office, the space agency does not expect the launch of the initial elements of the Gateway until at least December 2027. The baseline cost estimate is $5.3 billion.

NASA’s present plans contemplate using the Gateway as part of the Artemis IV mission, presently scheduled for September 2028. Unfortunately, the Gateway’s current launch target is already three months later than needed to support Artemis IV, the second mission to land humans on the Moon. But that’s OK. There are a lot of other moving parts for this mission, so a launch any time this decade would be a win.

The report includes a helpful cartoon to explain the complicated sequence that needs to happen for Gateway to be involved in the Artemis IV mission:

  • Launch of the initial segments of the Gateway, a power and propulsion module, and a habitation module, to a halo orbit around the Moon
  • Launch of a SpaceX Dragon XL vehicle to bring supplies to the Gateway
  • Launch of multiple SpaceX Starships to fuel a Lunar Starship, which will then fly to and dock with the Gateway
  • Launch of a NASA Space Launch System rocket carrying four astronauts inside an Orion spacecraft as well as another Gateway module
  • After launch, Orion separates from the rocket and docks with this module, the International Habitat
  • Orion tugs the International Habitat to the Gateway and docks; the crew exits onto Gateway
  • Two crew members board the Lunar Starship and go down to the Moon for six days
  • Starship flies back to the Gateway, and the four astronauts return to Earth inside Orion.
How the Artemis IV mission will (probably) take place.

How the Artemis IV mission will (probably) take place.

US GAO

In a rather understated manner, the report notes that this plan is fairly complex and faces some serious schedule risks.

“This mission will be complex because NASA will need to coordinate across seven NASA programs, multiple contractors that support those programs, and international partners to execute the mission,” the report states. “It will also be the first launch of an upgraded version of the Space Launch System rocket.”

Developmental difficulties

The report also finds that the Gateway program is running into some pretty serious technical difficulties. One involves a defective network chip that facilitates communication throughout the lunar space station. Its failure could cause myriad problems onboard the Gateway.

“For example, these defects could lead the flight computers to unexpectedly restart,” the report states. “If the network is not functioning properly, it could result in loss of control of the Gateway. Program officials are also concerned that they might identify more defects with the communication network, based on the number found already.”

Another risk involves something called “stack controllability.” This essentially means that because SpaceX’s Lunar Starship is so much more massive than the Gateway, when it is docked to the space station, the Gateway’s power and propulsion element (PPE) will not be able to maintain a proper orientation of the entire stack.

“Program officials estimate that the mass of the lunar lander Starship is approximately 18 times greater than the value NASA used to develop the PPE’s controllability parameters,” the report states. “According to NASA’s system engineering guidance, late requirements and design changes can lead to cost growth and schedule delays.”

The report also has some sobering conclusions about the potential utility of the Lunar Gateway for Mars missions. (In the past, NASA officials have spoken about the Gateway as a staging area for spacecraft and propellant for human missions to the surface of Mars.) However, the “stack controllability” issue poses a serious constraint to hosting large Mars transit vehicles. Moreover, the planned 15-year lifetime of the Gateway may not be long enough to sustain Mars missions.

“The Gateway could have exceeded its planned 15-year on-orbit life as early as 2042 when crewed missions to Mars are potentially just beginning,” the report states.

All in all, the report seems to suggest that the Gateway is way behind schedule and is of limited use to lunar and Mars landings. The report suggests the Gateway will be complex to undertake at the very same time NASA is attempting to establish a lunar surface program. But other than that, everything is going great.

NASA’s Lunar Gateway has a big visiting vehicles problem Read More »

karaoke-reveals-why-we-blush

Karaoke reveals why we blush

Biology, embarrassment, karaoke, neurobiology, Science / /

Singing for science —

Volunteers watched their own performances as an MRI tracked brain activity.

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A hand holding a microphone against a blurry backdrop, taken from an angle that implies the microphone is directly in front of your face.

Singing off-key in front of others is one way to get embarrassed. Regardless of how you get there, why does embarrassment almost inevitably come with burning cheeks that turn an obvious shade of red (which is possibly even more embarrassing)?

Blushing starts not in the face but in the brain, though exactly where has been debated. Previous thinking often reasoned that the blush reaction was associated with higher socio-cognitive processes, such as thinking of how one is perceived by others.

After studying subjects who watched videos of themselves singing karaoke, however, researchers led by Milica Nicolic of the University of Amsterdam have found that blushing is really the result of specific emotions being aroused.

Nicolic’s findings suggest that blushing “is a consequence of a high level of ambivalent emotional arousal that occurs when a person feels threatened and wants to flee but, at the same time, feels the urge not to give up,” as she and her colleagues put it in a study recently published in Proceedings of the Royal Society B.

Taking the stage

The researchers sought out test subjects who were most likely to blush when watching themselves sing bad karaoke: adolescent girls. Adolescents tend to be much more self-aware and more sensitive to being judged by others than adults are.

The subjects couldn’t pick just any song. Nicolic and her team had made sure to give them a choice of four songs that music experts had deemed difficult, which is why they selected “Hello” by Adele, “Let it Go” from Frozen, “All I Want For Christmas is You” by Mariah Carey, and “All the Things You Said” by tATu. Videos of the subjects were recorded as they sang.

On their second visit to the lab, subjects were put in an MRI scanner and were shown videos of themselves and others singing karaoke. They watched 15 video clips of themselves singing and, as a control, 15 segments of someone who was thought to have similar singing ability, so secondhand embarrassment could be ruled out.

The other control factor was videos of professional singers disguised as participants. Because the professionals sang better overall, it was unlikely they would trigger secondhand embarrassment.

Enough to make you blush

The researchers checked for an increase in cheek temperature, as blood flow measurements had been used in past studies but are more prone to error. This was measured with a fast-response temperature transducer as the subjects watched karaoke videos.

It was only when the subjects watched themselves sing that cheek temperature went up. There was virtually no increase or decrease when watching others—meaning no secondhand embarrassment—and a slight decrease when watching a professional singer.

The MRI scans revealed which regions of the brain were activated as subjects watched videos of themselves. These include the anterior insular cortex, or anterior insula, which responds to a range of emotions, including fear, anxiety, and, of course, embarrassment. There was also the mid-cingulate cortex, which emotionally and cognitively manages pain—including embarrassment—by trying to anticipate that pain and reacting with aversion and avoidance. The dorsolateral prefrontal cortex, which helps process fear and anxiety, also lit up.

There was also more activity detected in the cerebellum, which is responsible for much of the emotional processing in the brain, when subjects watched themselves sing. Those who blushed more while watching their own video clips showed the most cerebellum activity. This could mean they were feeling stronger emotions.

What surprised the researchers was that there was no additional activation in areas known for being involved in the process of understanding one’s mental state, meaning someone’s opinion of what others might think of them may not be necessary for blushing to happen.

So blushing is really more about the surge of emotions someone feels when being faced with things that pertain to the self and not so much about worrying what other people think. That can definitely happen if you’re watching a video of your own voice cracking at the high notes in an Adele song.

Proceedings of the Royal Society B, 2024.  DOI: 10.1098/rspb.2024.0958

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Boeing’s Starliner has cost at least twice as much as SpaceX’s Crew Dragon

Boeing, commercial crew, international space station, NASA, Science, Space, starliner / /

$$$ —

“Risk remains that we may record additional losses in future periods.”

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A Starliner spacecraft departs Boeing's spacecraft processing facility before the program's first orbital test flight in 2019.

Enlarge / A Starliner spacecraft departs Boeing’s spacecraft processing facility before the program’s first orbital test flight in 2019.

Boeing announced another financial charge Wednesday for its troubled Starliner commercial crew program, bringing the company’s total losses on Starliner to $1.6 billion.

In its quarterly earnings report, Boeing registered a $125 million loss on the Starliner program, blaming delays on the spacecraft’s still-ongoing Crew Flight Test, the program’s first mission to carry astronauts into orbit. This is not the first time Boeing has reported a financial loss on Starliner. Including the new charge announced Wednesday, Boeing has now suffered an overall loss on the program of nearly $1.6 billion since 2016.

These losses have generally been caused by schedule delays and additional work to solve problems on Starliner. When NASA awarded Boeing a $4.2 billion contract to complete development of the Starliner spacecraft a decade ago, the aerospace contractor projected the capsule would be ready to fly astronauts by the end of 2017.

It turns out the Crew Flight Test didn’t launch until June 5, 2024.

In a separate announcement Wednesday, Boeing named Kelly Ortberg as the company’s CEO, effective August 8. He will replace Dave Calhoun, whose tenure as Boeing’s chief executive was marred by scandals with the 737 MAX passenger airplane. Ortberg was previously CEO of Rockwell Collins, now known as Collins Aerospace, a major supplier of avionics and other parts for the aerospace industry.

Boeing is on the hook

When NASA selected Boeing and SpaceX to develop the Starliner and Crew Dragon spacecraft for astronaut missions, the agency signed fixed-price agreements with each contractor. These fixed-price contracts mean the contractors, not the government, are responsible for paying for cost overruns.

So, with each Starliner delay since 2016, Boeing’s financial statements registered new losses. It will be Boeing’s burden to pay for solutions to problems discovered on Starliner’s ongoing crew test flight. That’s why Boeing warned investors Wednesday that it could lose more money on the Starliner program in the coming months and years.

“Risk remains that we may record additional losses in future periods,” Boeing wrote in an SEC filing.

Taking into account the financial loss revealed Wednesday, NASA and Boeing have committed at least $6.7 billion to the Starliner program since 2010, including expenses for spacecraft development, testing, and the government’s payment for six operational crew flights with Starliner.

It’s instructive to compare these costs with those of SpaceX’s Crew Dragon program, which started flying astronauts in 2020. All of NASA’s contracts with SpaceX for a similar scope of work on the Crew Dragon program totaled more than $3.1 billion, but any expenses paid by SpaceX are unknown because it is a privately held company.

SpaceX has completed all six of its original crew flights for NASA, while Boeing is at least a year away from starting operational service with Starliner. In light of Boeing’s delays, NASA extended SpaceX’s commercial crew contract to cover eight additional round-trip flights to the space station through the end of the 2020s.

Boeing’s leaders blame the structure of fixed-price contracts for the losses on the Starliner program. The aerospace giant has similar fixed-price contracts with the Pentagon to develop new two new Air Force One presidential transport aircraft, Air Force refueling tankers, refueling drones, and trainer airplanes. Boeing has reported losses on those programs, too.

SpaceX, meanwhile, has excelled with fixed-price contracts, which NASA uses on several elements of the Artemis program aiming to land astronauts on the Moon. For example, NASA selected SpaceX and Blue Origin, Jeff Bezos’s space company, for fixed-price contracts to develop human-rated lunar landers. SpaceX also won a fixed-price contract to provide NASA with a vehicle to deorbit the International Space Station at the end of its life.

Decision time

The first crew mission aboard Boeing’s Starliner spacecraft is expected to end sometime in August with the return of NASA astronauts Butch Wilmore and Suni Williams from the International Space Station. A successful conclusion of the test flight would pave the way for Boeing to start launching its backlog of six operational crew missions to the space station.

But it hasn’t been that simple. The Starliner test flight was initially expected to stay at the space station for at least eight days. Before the launch in June, NASA and Boeing officials left open the possibility for a mission extension, but managers didn’t anticipate Starliner to still be docked at the space station more than 50 days later.

Mission managers ordered Starliner to stay at the station through the rest of June and July while engineers investigated problems in the spacecraft’s propulsion system. There are helium leaks in Starliner’s service module, and the craft’s small maneuvering thrusters overheated during the final approach for docking at the space station.

NASA, which oversees Boeing’s commercial crew contract, is getting close to clearing Starliner for return to Earth, perhaps as soon as next week. On Saturday, ground controllers commanded Starliner to test-fire its maneuvering thrusters, and 27 of the 28 jets appeared to function normally despite overheating earlier in the mission. Despite the leaks, the spacecraft also has ample helium to pressurize its propulsion system, NASA officials said.

Before giving final approval for Starliner to undock from the space station and return to Earth, senior NASA leaders will convene a readiness review to go over the results of the investigation into the propulsion issues.

Boeing has some work to do to find a long-term fix for the helium leaks and overheating thrusters on future Starliner missions. NASA officials hoped a flawless Starliner test flight would allow the agency to formally certify the capsule for regular six-month expeditions to the space station by the end of the year, allowing Boeing to launch the first operational Starliner flight, known as Starliner-1, in February 2025.

Last week, NASA announced a six-month delay for the Starliner-1 mission to allow more time to solve the problems the spacecraft experienced on the crew test flight.

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7 million pounds of meat recalled amid deadly outbreak

CDC, deaths, health, Infectious disease, listeria, Listeria monocytogenes, Meat, outbreak, recall, Science, USDA / /

7 million pounds across 71 products —

Authorities worry that the contaminated meats are still sitting in people’s fridges.

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Shelves sit empty where Boar's Head meats are usually displayed at a Safeway store on July 31, 2024, in San Anselmo, California.

Enlarge / Shelves sit empty where Boar’s Head meats are usually displayed at a Safeway store on July 31, 2024, in San Anselmo, California.

Over 7 million pounds of Boar’s Head brand deli meats are being recalled amid a bacterial outbreak that has killed two people. The outbreak, which began in late May, has sickened a total of 34 people across 13 states, leading to 33 hospitalizations, according to the US Department of Agriculture.

On June 26, Boar’s Head recalled 207,528 pounds of products, including liverwurst, beef bologna, ham, salami, and “heat and eat” bacon. On Tuesday, the Jarratt, Virginia-based company expanded the recall to include about 7 million additional pounds of meat, including 71 different products sold on the Boar’s Head and Old Country brand labels. The products were sold nationwide.

The meats may be contaminated with Listeria monocytogenes, a foodborne pathogen that is particularly dangerous to pregnant people, people over the age of 65, and people with compromised immune systems. Infections during pregnancy can cause miscarriage, stillbirth, premature delivery, or a life-threatening infection in newborns. For others who develop invasive illness, the fatality rate is nearly 16 percent. Symptoms of listeriosis can include fever, muscle aches, headache, stiff neck, confusion, loss of balance, and convulsions that are sometimes preceded by diarrhea or other gastrointestinal symptoms.

The problem was discovered when the Maryland Department of Health—working with the Baltimore City Health Department—collected an unopened liverwurst product from a retail store and found that it was positive for L. monocytogenes. In later testing, the strain in the liverwurst was linked to those isolated from people sickened in the outbreak.

According to the Centers for Disease Control and Prevention, six of the 34 known cases were identified in Maryland, and 12 were identified in New York. The other 11 states have only reported one or two cases each. However, the CDC expects the true number of infections to be much higher, given that many people recover without medical care and, even if people did seek care, health care providers do not routinely test for L. monocytogenes in people with mild gastrointestinal illnesses.

In the outbreak so far, there has been one case in a pregnant person, who recovered and remained pregnant. The two deaths occurred in New Jersey and Illinois.

In a statement on the company’s website, Boar’s Head said that it learned from the USDA on Monday night that L. monocytogenes strain in the liverwurst linked to the multistate outbreak. “Out of an abundance of caution, we decided to immediately and voluntarily expand our recall to include all items produced at the Jarratt facility. We have also decided to pause ready-to-eat operations at this facility until further notice. As a company that prioritizes safety and quality, we believe it is the right thing to do.”

The USDA said it is “concerned that some product may be in consumers’ refrigerators and in retail deli cases.” The USDA, the company, and CDC warn people not to eat the recalled products. Instead, they should either be thrown away or returned to the store where they were purchased for a full refund. And if you’ve purchased one of the recalled products, the USDA also advises you to thoroughly clean your fridge to prevent cross-contamination.

7 million pounds of meat recalled amid deadly outbreak Read More »

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How Kepler’s 400-year-old sunspot sketches helped solve a modern mystery

astronomy, astrophysics, Johannes Kepler, Physics, Science, solar physics, sun spots / /
A naked-eye sunspot group on 11 May 2024

Enlarge / A naked-eye sunspot group on May 11, 2024. There are typically 40,000 to 50,000 sunspots observed in ~11-year solar cycles.

E. T. H. Teague

A team of Japanese and Belgian astronomers has re-examined the sunspot drawings made by 17th century astronomer Johannes Kepler with modern analytical techniques. By doing so, they resolved a long-standing mystery about solar cycles during that period, according to a recent paper published in The Astrophysical Journal Letters.

Precisely who first observed sunspots was a matter of heated debate in the early 17th century. We now know that ancient Chinese astronomers between 364 and 28 BCE observed these features and included them in their official records. A Benedictine monk in 807 thought he’d observed Mercury passing in front of the Sun when, in reality, he had witnessed a sunspot; similar mistaken interpretations were also common in the 12th century. (An English monk made the first known drawings of sunspots in December 1128.)

English astronomer Thomas Harriot made the first telescope observations of sunspots in late 1610 and recorded them in his notebooks, as did Galileo around the same time, although the latter did not publish a scientific paper on sunspots (accompanied by sketches) until 1613. Galileo also argued that the spots were not, as some believed, solar satellites but more like clouds in the atmosphere or the surface of the Sun. But he was not the first to suggest this; that credit belongs to Dutch astronomer Johannes Fabricus, who published his scientific treatise on sunspots in 1611.

Kepler read that particular treatise and admired it, having made his sunspot observations using a camera obscura in 1607 (published in a 1609 treatise), which he initially thought was a transit of Mercury. He retracted that report in 1618, concluding that he had actually seen a group of sunspots. Kepler made his solar drawings based on observations conducted both in his own house and in the workshop of court mechanic Justus Burgi in Prague.  In the first case, he reported “a small spot in the size of a small fly”; in the second, “a small spot of deep darkness toward the center… in size and appearance like a thin flea.”

The earliest datable sunspot drawings based on Kepler's solar observations with camera obscura in May 1607.

Enlarge / The earliest datable sunspot drawings based on Kepler’s solar observations with camera obscura in May 1607.

Public domain

The long-standing debate that is the subject of this latest paper concerns the period from around 1645 to 1715, during which there were very few recorded observations of sunspots despite the best efforts of astronomers. This was a unique event in astronomical history. Despite only observing some 59 sunspots during this time—compared to between 40,000 to 50,000 sunspots over a similar time span in our current age—astronomers were nonetheless able to determine that sunspots seemed to occur in 11-year cycles.

German astronomer Gustav Spörer noted the steep decline in 1887 and 1889 papers, and his British colleagues, Edward and Annie Maunder, expanded on that work to study how the latitudes of sunspots changed over time. That period became known as the “Maunder Minimum.” Spörer also came up with “Spörer’s law,” which holds that spots at the start of a cycle appear at higher latitudes in the Sun’s northern hemisphere, moving to successively lower latitudes in the southern hemisphere as the cycle runs its course until a new cycle of sunspots begins in the higher latitudes.

But precisely how the solar cycle transitioned to the Maunder Minimum has been far from clear. Reconstructions based on tree rings have produced conflicting data. For instance, one such reconstruction concluded that the gradual transition was preceded either by an extremely short solar cycle of about five years or an extremely long solar cycle of about 16 years. Another tree ring reconstruction concluded the solar cycle would have been of normal 11-year duration.

Independent observational records can help resolve the discrepancy. That’s why Hisashi Hayakawa of Nagoya University in Japan and co-authors turned to Kepler’s drawings of sunspots for additional insight, which predate existing telescopic observations by several years.

How Kepler’s 400-year-old sunspot sketches helped solve a modern mystery Read More »

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Webb confirms: Big, bright galaxies formed shortly after the Big Bang

astronomy, cosmology, galaxies, galaxy formation, Science, Webb telescope / /

They grow up so fast —

Structure of galaxy rules out early, bright objects were supermassive black holes.

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Image of a field of stars and galaxies.

Enlarge / Some of the galaxies in the JADES images.

One of the things that the James Webb Space Telescope was designed to do was look at some of the earliest objects in the Universe. And it has already succeeded spectacularly, imaging galaxies as they existed just 250 million years after the Big Bang. But these galaxies were small, compact, and similar in scope to what we’d consider a dwarf galaxy today, which made it difficult to determine what was producing their light: stars or an actively feeding supermassive black hole at their core.

This week, Nature is publishing confirmation that some additional galaxies we’ve imaged also date back to just 300 million years after the Big Bang. Critically, one of them is bright and relatively large, allowing us to infer that most of its light was coming from a halo of stars surrounding its core, rather than originating in the same area as the central black hole. The finding implies that it formed through a continuing burst of star formation that started just 200 million years after the Big Bang.

Age checks

The galaxies at issue here were first imaged during the JADES (JWST Advanced Deep Extragalactic Survey) imaging program, which includes part of the area imaged for the Hubble Ultra Deep Field. Initially, old galaxies were identified by using a combination of filters on one of Webb’s infrared imaging cameras.

Most of the Universe is made of hydrogen, and figuring out the age of early galaxies involves looking for the most energetic transitions of hydrogen’s electron, called the Lyman series. These transitions produce photons that are in the UV area of the spectrum. But the redshift of light that’s traveled for billions of years will shift these photons into the infrared area of the spectrum, which is what Webb was designed to detect.

What this looks like in practice is that hydrogen-dominated material will emit a broad range of light right up to the highest energy Lyman transition. Above that energy, photons will be sparse (they may still be produced by things like processes that accelerate particles). This point in the energy spectrum is called the “Lyman break,” and its location on the spectrum will change based on how distant the source is—the greater the distance to the source, the deeper into the infrared the break will appear.

Initial surveys checked for the Lyman break using filters on Webb’s cameras that cut off different areas of the IR spectrum. Researchers looked for objects that showed up at low energies but disappeared when a filter that selected for higher-energy infrared photons was swapped in. The difference in energies between the photons allowed through by the two filters can provide a rough estimate of where the Lyman break must be.

Locating the Lyman break requires imaging with a spectrograph, which can sample the full spectrum of near-infrared light. Fortunately, Webb has one of those, too. The newly published study involved turning the NIRSpec onto three early galaxies found in the JADES images.

Too many, too soon

The researchers involved in the analysis only ended up with data from two of these galaxies. NIRSpec doesn’t gather as much light as one of Webb’s cameras can, and so the faintest of the three just didn’t produce enough data to enable analysis. The other two, however, produced very clear data that placed the galaxies at a redshift measure roughly z = 14, which means we’re seeing them as they looked 300 million years after the Big Bang. Both show sharp Lyman breaks, with the amount of light dropping gradually as you move further into the lower-energy part of the spectrum.

There’s a slight hint of emissions from heavily ionized carbon atoms in one of the galaxies, but no sign of any other specific elements beyond hydrogen.

One of the two galaxies was quite compact, so similar to the other galaxies of this age that we’d confirmed previously. But the other, JADES-GS-ZZ14-0, was quite distinct. For starters, it’s extremely bright, being the third most luminous distant galaxy out of hundreds we’ve imaged so far. And it’s big enough that it’s not possible for all its light to be originating from the core. That rules out the possibility that what we’re looking at is a blurred view of an active galactic nucleus powered by a supermassive black hole feeding on material.

Instead, much of the light we’re looking at seems to have originated in the stars of JADES-GS-ZZ14-0. Most of those stars are young, and there seems to be very little of the dust that characterizes modern galaxies. The researchers estimate that star formation started at least 100 million years earlier (meaning just 200 million years after the Big Bang) and continued at a rapid pace in the intervening time.

Combined with earlier data, the researchers write that this confirms that “bright and massive galaxies existed already only 300 [million years] after the Big Bang, and their number density is more than ten times higher than extrapolations based on pre-JWST observations.” In other words, there were a lot more galaxies around in the early Universe than we thought, which could pose some problems for our understanding of the Universe’s contents and their evolution.

Meanwhile, the early discovery of the extremely bright galaxy implies that there are a number of similar ones out there awaiting our discovery. This means there’s going to be a lot of demand for time on NIRSpec in the coming years.

Nature, 2024. DOI: 10.1038/s41586-024-07860-9  (About DOIs).

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