Science

every-homeopathic-eye-drop-should-be-pulled-off-the-market,-fda-says

Every homeopathic eye drop should be pulled off the market, FDA says

eye drops, fda, health, homeopathic, infection, Science, Vision / /

don’t risk it —

Eye drops are uniquely risky because the eye is an immune-privileged site.

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Young man applying eye drops.

This year has been marked by many terrifying things, but perhaps the most surprising of the 2023 horrors was … eye drops.

The seemingly innocuous teeny squeeze bottle made for alarming headlines numerous times during our current revolution around the sun, with lengthy lists of recalls, startling factory inspections, and ghastly reports of people developing near-untreatable bacterial infections, losing their eyes and vision, and dying.

Recapping this unexpected threat to health, the Food and Drug Administration on Tuesday released an advisory titled “What You Should Know about Eye Drops” in hopes of keeping the dangers of this year from leaking into the next. Among the notable points from the regulator was this stark pronouncement: No one should ever use any homeopathic ophthalmic products, and every single such product should be pulled off the market.

The point is unexpected, given that none of the high-profile infections and recalls this year involved homeopathic products. But, it should be welcomed by any advocates of evidence-based medicine.

Homeopathy is an 18th century pseudoscience that produces bogus remedies that work no better than a placebo and, if prepared improperly, can be toxic, even deadly. The practice relies on two false principles: the  “law of similars,” aka “like cures like,” meaning a substance that causes a specific symptom in a healthy person can treat conditions and diseases that involve that same symptom, and the “law of infinitesimals,” which states that diluting the substance renders it more potent. As such, homeopathic products begin with toxic substances that are then extremely diluted—often into oblivion—in a ritualistic procedure. Some homeopaths hold that water molecules can have “memory.”

Clear risks

In the US, these products are marketed as legitimate treatments and sold alongside evidence-based treatments (though consumer advocates are trying to change that). The reason this is allowed for now is because of a regulatory quirk: Based on the 1938 Food, Drug, and Cosmetic Act, homeopathic products are generally considered exempt from pre-market FDA safety and efficacy reviews as long as the active ingredient in the product is included in the Homeopathic Pharmacopoeia, a list of substances approved by homeopaths.

In recent years, the FDA and the Federal Trade Commission have cracked down on homeopathic products, though. And it seems from today’s advisory that the FDA is not holding back on homeopathic products for the eyes. The regulator notes that any products meant for the eye “pose a heightened risk of harm” because the eyes are an immune-privileged site in the body. That is, innate immune responses are restrained in the eye to prevent damaging inflammation, which could threaten vision. “Any drug used in the eyes must be sterile to reduce the risk of infection,” the FDA said.

But whether or not homeopathic eye drops are labeled as sterile doesn’t seem to matter to the FDA. The regulator cautions: “Do not use ophthalmic products that: Are labeled as homeopathic, as these products should not be marketed.” Their lack of pre-market safety and efficacy reviews appears to be enough to warrant avoidance.

The FDA also cautions consumers not to use any over-the-counter eye drop product that claims to treat glaucoma, cataracts, retinopathy, or macular degeneration because there are simply no actual over-the-actual treatments for these conditions. If a non-prescription product claims this, you can assume it’s bogus and avoid it. Consumers should also avoid anything that includes Methylsulfonylmethane (MSM), which is illegally sold in the US, and anything with silver sulfate or argentum because these can permanently change the white color of your eyes.

Every homeopathic eye drop should be pulled off the market, FDA says Read More »

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CVS, Rite Aid, Walgreens hand out medical records to cops without warrants

Amazon, cops, cvs, health, health privacy, HHS, HIPAA, law enforcement, Medical records, pharmacy, Policy, prescription drugs, rite aid, Science, Walgreens, warrant / /

prescription for privacy —

Lawmakers want HHS to revise health privacy law to require warrants.

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CVS, Rite Aid, Walgreens hand out medical records to cops without warrants

All of the big pharmacy chains in the US hand over sensitive medical records to law enforcement without a warrant—and some will do so without even running the requests by a legal professional, according to a congressional investigation.

The revelation raises grave medical privacy concerns, particularly in a post-Dobbs era in which many states are working to criminalize reproductive health care. Even if people in states with restrictive laws cross state lines for care, pharmacists in massive chains, such as CVS, can access records across borders.

Lawmakers noted the pharmacies’ policies for releasing medical records in a letter dated Tuesday to the Department of Health and Human Services (HHS) Secretary Xavier Becerra. The letter—signed by Sen. Ron Wyden (D-Ore.), Rep. Pramila Jayapal (D-Wash.), and Rep. Sara Jacobs (D-Calif.)—said their investigation pulled information from briefings with eight big prescription drug suppliers.

They include the seven largest pharmacy chains in the country: CVS Health, Walgreens Boots Alliance, Cigna, Optum Rx, Walmart Stores, Inc., The Kroger Company, and Rite Aid Corporation. The lawmakers also spoke with Amazon Pharmacy.

All eight of the pharmacies said they do not require law enforcement to have a warrant prior to sharing private and sensitive medical records, which can include the prescription drugs a person used or uses and their medical conditions. Instead, all the pharmacies hand over such information with nothing more than a subpoena, which can be issued by government agencies and does not require review or approval by a judge.

Three pharmacies—CVS Health, The Kroger Company, and Rite Aid Corporation—told lawmakers they didn’t even require their pharmacy staff to consult legal professionals before responding to law enforcement requests at pharmacy counters. According to the lawmakers, CVS, Kroger, and Rite Aid said that “their pharmacy staff face extreme pressure to immediately respond to law enforcement demands and, as such, the companies instruct their staff to process those requests in store.”

The rest of the pharmacies—Amazon, Cigna, Optum Rx, Walmart, and Walgreens Boots Alliance—at least require that law enforcement requests be reviewed by legal professionals before pharmacists respond. But, only Amazon said it had a policy of notifying customers of law enforcement demands for pharmacy records unless there were legal prohibitions to doing so, such as a gag order.

HIPAA and transparency

The lawmakers note that the pharmacies aren’t violating regulations under the Health Insurance Portability and Accountability Act (HIPAA). The pharmacies pointed to language in HIPAA regulations that allow health care providers, including pharmacists, to provide medical records if required by law, with subpoenas being a sufficient legal process for such a request. However, the lawmakers note that the HHS has discretion in determining the legal standard here—that is, it has the power to strengthen the regulation to require a warrant, which the lawmakers say it should do.

“We urge HHS to consider further strengthening its HIPAA regulations to more closely align them with Americans’ reasonable expectations of privacy and Constitutional principles,” the three lawmakers wrote.

They also pushed for pharmacies to do better, encouraging them to follow the lead of tech companies. “Pharmacies can and should insist on a warrant, and invite law enforcement agencies that insist on demanding patient medical records with solely a subpoena to go to court to enforce that demand. The requirement for a warrant is exactly the approach taken by tech companies to protect customer privacy.” The trio noted that Google, Microsoft, and Yahoo have since 2010 required law enforcement to have a warrant to obtain customers’ emails.

Also noting tech companies’ lead, the lawmakers encouraged pharmacies to publish annual transparency reports. In the course of the investigation, only CVS Health said it planned to do so.

“Americans deserve to have their private medical information protected at the pharmacy counter and a full picture of pharmacies’ privacy practices, so they can make informed choices about where to get their prescriptions filled,” the lawmakers wrote.

For now, HIPAA regulations grant patients the right to know who is accessing their health records. But, to do so, patients have to specifically request that information—and almost no one does that. “Last year, CVS Health, the largest pharmacy in the nation by total prescription revenue, only received a single-digit number of such consumer requests,” the lawmakers noted.

“The average American is likely unaware that this is even a problem,” the lawmakers said.

CVS, Rite Aid, Walgreens hand out medical records to cops without warrants Read More »

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After 15 months Blue Origin’s New Shepard spacecraft will finally fly again

blue origin, new shepard, Science, Space / /

Blue is back —

Taking some science and some postcards for a ride.

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Photos from New Shepard launch day.

Enlarge / Blue Origin’s New Shepard launch system consists of a booster and a capsule.

Blue Origin is finally returning to flight.

On Tuesday the company announced, via the social media site X, that its New Shepard spacecraft would launch no earlier than next Monday.

“We’re targeting a launch window that opens on Dec. 18 for our next New Shepard payload mission,” the company stated. “#NS24 will carry 33 science and research payloads as well as 38,000 @clubforfuture postcards to space.”

The uncrewed New Shepard 24 test flight will refly the science payloads that were aboard the New Shepard 23 flight, which experienced an engine nozzle failure at 1 minute and 4 seconds following liftoff in September 2022. The capsule’s emergency escape system performed as intended, rapidly pulling the spacecraft away from the disintegrating rocket and allowing Blue Origin to recover the payloads flown for NASA and other customers.

Blue Origin finished its accident analysis this spring and implemented a fix to the problem, including design changes to the BE-3 engine combustion chamber. In May, the company said it planned to return to flight “soon.” Then, in September, the Federal Aviation Administration closed its mishap investigation.

The company originally targeted an uncrewed return-to-flight mission in early October; however, two sources told Ars that the additional two-month delay was caused by an issue with certifying an engine part intended for flight.

A new rocket?

Blue Origin has not specified which rocket and spacecraft will be flying next week from its launch site in West Texas, near the town of Van Horn. The company’s first New Shepard rocket, Booster 1, was lost during an April 2015 flight. Booster 2 was retired in October 2016 after performing a successful test of the launch escape system on its fifth and final flight. Booster 3, which was lost during the NS-23 mission in September, was the company’s oldest operational rocket, making its debut in December 2017.

The company has used its newest rocket, Booster 4, exclusively for human launches on New Shepard. This rocket has some modifications from Booster 3 to qualify it as a human-rated rocket. The company has also built a fifth booster that may be making next Monday’s flight.

Tuesday’s announcement came amid a tidal wave of changes in leadership at Blue Origin this month, with several high-profile retirements and the arrival of its new chief executive, who has come to the company from Amazon, Dave Limp. He replaced Bob Smith, who had an uneven tenure as leader of Blue Origin. As Ars reported last month, Limp is likely evaluating the long-term prospects of New Shepard, which remains far from breaking even financially.

The company may pivot toward its larger projects, including the New Glenn rocket and lunar lander for the Artemis program, which have a greater chance of raising significant revenue. Amazon founder Jeff Bezos has funded Blue Origin out of his pocket, providing as much as $2 billion a year in operating expenses.

However, given the announcement of New Shepard’s return to flight, it’s clear that Blue Origin isn’t moving entirely away from New Shepard just yet.

After 15 months Blue Origin’s New Shepard spacecraft will finally fly again Read More »

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AI companion robot helps some seniors fight loneliness, but others hate it

Aging, AI, companion robot, depression, ElliQ, health, loneliness, new york, Science / /

AI buddy —

There’s limited evidence for health benefits so far; early work suggests no one-size-fits-all.

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ElliQ, an AI companion robot from Intuition Robotics.

Enlarge / ElliQ, an AI companion robot from Intuition Robotics.

Some seniors in New York are successfully combating their loneliness with an AI-powered companion robot named ElliQ—while others called the “proactive” device a nag and joked about taking an ax to it.

The home assistant robot, made by Israel-based Intuition Robotics, is offered to New York seniors through a special program through the state’s Office for the Aging (NYSOFA). Over the past year, NYSOFA has partnered with Intuition Robotics to bring ElliQ to over 800 seniors struggling with loneliness. In a report last week, officials said they had given out hundreds and had only 150 available devices.

ElliQ includes a tablet and a two-piece lamp-like robot with a head that lights up and rotates to face a speaker. Marketed as powered by “Cognitive AI technology,” it proactively engages in conversations with users, giving them reminders and prompts, such as asking them how they’re doing, telling them it’s time to check their blood pressure or take their medicine, and asking if they want to have a video call with family. Speaking with a female voice, the robot is designed to hold human-like conversations, engage in small talk, express empathy, and share humor. It can provide learning and wellness programs, such as audiobooks and relaxation exercises.

Interest in using social robots, such as ElliQ, for elder care has been growing for years, but the field still lacks solid evidence that the devices can significantly improve health, well-being, and depression. Systemic reviews in 2018 found the technology had potential, but studies lacked statistical significance and rigorous design.

The program in New York adds to the buzz but doesn’t offer the high-quality study design that could yield definitive answers. In August, the state released a report on an unspecified number of ElliQ users, which indicated that the device was helpful. Specifically, 59 percent of users reported the device was “very helpful” at reducing loneliness, while 37 percent reported it was “helpful” and only 4 percent reported it as “unhelpful.” Engagement with the device declined over time, with users initially interacting with ElliQ an average of 62 times a day in the first 15 days of use, which fell to 21 times a day between 60 and 90 days and 33 times a day after 180.

Mixed feelings

“We had high hopes for the efficacy of ElliQ, but the results that we’re seeing are truly exceeding our expectations,” Greg Olsen, director of the New York State Office for the Aging, said in a statement at the time of the report’s release. “The data speaks for itself, and the stories that we’re hearing from case managers and clients around the state have been nothing short of unbelievable.”

But other recent data on the potential for companion robots to reduce loneliness has indicated that there’s no one-size-fits-all approach. There are a lot of factors that can influence how individuals perceive such a device. A 2021 qualitative study evaluated the responses from 16 seniors who were asked for feedback on three types of robot companions, including ElliQ. The results were mixed for the proactive robot. While some felt the occasional chattiness of ElliQ would be comforting during an otherwise solitary day, others felt it was intrusive and “nagging.” Some felt the device’s tone was “rude.”

“I don’t know whether that would drive me mental if it kept interrupting me and telling me what to do … I might want to get an ax and cut it up,” one study participant said.

How welcoming a person might be to an assertive AI-assistant like ElliQ may link with a person’s general preferences regarding human company, the authors suggested. Those who value their space and autonomy may be less open to such as device compared with more gregarious seniors.

While some participants said ElliQ’s reminders could be useful, others expressed a deep concern that an overreliance on technology for everyday tasks—like paying bills, taking medications, or turning lights off—could hasten the decline of cognitive and physical abilities. Study participants also raised concerns regarding the inauthenticity of a relationship with a nonhuman, a loss of dignity, and a lack of control. Some disliked that ElliQ couldn’t be fully controlled by the user and was so assertive, which some perceived as pushy. Some worried about feeling embarrassed about being seen interacting with a robot companion. A 2022 study also explored the issue of stigma, with participants expressing that the use of such devices could reinforce stereotypes of aging, including isolation and dependency.

While researchers continue to explore the potential use and design of AI-powered companion robots, anecdotes from New York’s program suggest the tools are clearly helpful for some. One New Yorker named Priscilla told CBS News she found ElliQ helpful.

“She keeps me company. I get depressed real easy. She’s always there. I don’t care what time of day, if I just need somebody to talk to me,” Priscilla said. “I think I said that’s the biggest thing, to hear another voice when you’re lonely.”

AI companion robot helps some seniors fight loneliness, but others hate it Read More »

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OPEC members keep climate accords from acknowledging reality

carbon emissions, climate change, COP28, fossil fuels, paris agreement, Policy, Science, UN / /

Avoiding the truth —

COP28 agreement draft no longer includes calls to phase out fossil fuels.

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Image of a person standing in front of a doorway with

Enlarge / Saudi Arabia’s presence at COP28 has reportedly been used to limit progress on fossil fuel cutbacks.

Oil-producing countries are apparently succeeding in their attempts to eliminate language from an international climate agreement that calls for countries to phase out the use of fossil fuels. Draft forms of the agreement had included text that called upon the countries that are part of the Paris Agreement to work toward “an orderly and just phase out of fossil fuels.” Reports now indicate that this text has gone missing from the latest versions of the draft.

The agreement is being negotiated at the United Nations’ COP28 climate change conference, taking place in the United Arab Emirates. The COP, or Conference of the Parties, meetings are annual events that attempt to bring together UN members to discuss ways to deal with climate change. They were central to the negotiations that brought about the Paris Agreement, which calls for participants to develop plans that should bring the world to net-zero emissions by the middle of the century.

Initial plans submitted by countries would lower the world’s greenhouse gas emissions, but not by nearly enough to reach net zero. However, the agreement included mechanisms by which countries would continue to evaluate their progress and submit more stringent goals. So, additional COP meetings have included what’s termed a “stocktake” to evaluate where countries stand, and statements are issued to encourage and direct future actions.

The language of that statement needs to be agreed upon by every party and is invariably contentious. This year’s statement has been especially difficult, as early drafts (such as this one) included the potential to call for parties to stop using fossil fuels, along with a separate, vague alternative:

Option 1: An orderly and just phase out of fossil fuels;

Option 2: Accelerating efforts toward phasing out unabated fossil fuels and to rapidly reducing their use so as to achieve net zero CO2 in energy systems by or around mid-century;

Option 3: No text.

The “unabated” language in the alternative is widely interpreted as referring to abatement via the use of large-scale carbon capture to offset the emissions from continued fossil fuel use.

While we know that carbon capture can work, it has not been tried at large scales, much less on anything close to the scales needed to offset continued fossil fuel use. Critical details like the capacity and stability of different storage options haven’t been worked out, nor has the very tricky question of who will be paying to operate all the infrastructure that would be required for it to work.

As a result, carbon capture is not generally considered a viable option for offsetting anything more than a few difficult-to-decarbonize use cases, such as international shipping. Which why most countries and NGOs are supporting the UN’s secretary-general, who promoted the alternate language calling for a phase-out of fossil fuels.

Most, but not all. One notable NGO, OPEC, directly called on its members to reject any language that targeted fossil fuels. And a prominent OPEC member, Saudia Arabia, appears to have been trying to block any deals that would include that language, in part by bogging down all negotiations at COP28. Matters weren’t helped when a video surfaced that showed the conference’s host, Sultan Al Jaber, saying that there was “no science” behind calls to phase out fossil fuels, although he quickly disavowed that position.

The loss of Option 1 from the latest drafts is a sign that oil-producing nations have succeeded. Which in turn indicates that they have no intention of slowing production even as indications of continued warming and its consequences have grown ever more dramatic. It will also provide cover for many other countries that may be looking for excuses to act.

That said, the same draft includes several actions that do not have any alternative language and call for countries to take significant actions:

  • Triple renewable energy capacity by 2030.
  • Double the annual rate of energy efficiency improvements.
  • Immediately stop issuing permits for coal plants that do not include carbon capture and rapidly phase out any existing plants of this sort.
  • Rapidly phase in zero-emissions vehicles.
  • Eliminate fossil fuel subsidies.

Negotiations are ongoing, and that draft is nearly a week old, but it may indicate that some positive things could be accomplished while everyone is distracted by arguments over the phase-out of fossil fuels.

OPEC members keep climate accords from acknowledging reality Read More »

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ULA chief says Vulcan rocket will slip to 2024 after ground system issues

rockets, Science, Space, ula, Uncategorized, vulcan / /

ULA delay —

The Colorado-based launch company will end 2023 with just three launches.

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ULA's Vulcan rocket rolls to the launch pad for testing.

Enlarge / ULA’s Vulcan rocket rolls to the launch pad for testing.

United Launch Alliance

United Launch Alliance will not see the debut of its next-generation Vulcan rocket in 2023, as previously planned.

The launch company’s chief executive, Tory Bruno, announced the delay on the social media site X on Sunday. United Launch Alliance had been working toward a debut flight of the lift booster on Christmas Eve, from Cape Canaveral Space Force Station in Florida.

Bruno made the announcement after the company attempted to complete a fueling test of the entire rocket, known as a wet dress rehearsal.

“Vehicle performed well,” Bruno wrote. “Ground system had a couple of (routine) issues, (being corrected). Ran the timeline long so we didn’t quite finish. I’d like a FULL WDR before our first flight, so XMAS eve is likely out. Next Peregrine window is 8 Jan.”

Peregrine is the rocket’s primary payload, a lunar lander built by Astrobotic that is intended to deliver scientific experiments for NASA and other payloads the Moon. It has specific launch windows in order to reach the Moon and attempt a landing during ideal lighting conditions.

From the information contained in Bruno’s comment, it appears as though the work to correct the ground systems to fuel Vulcan—the first stage propellant is methane, which United Launch Alliance has not worked with before—will take long enough that it will preclude another fueling test ahead of the rocket’s late December launch window. Thus, the next launch attempt will likely occur no earlier than January 8.

A light cadence

It has been a slow year for United Launch Alliance, which dominated the US launch industry a decade ago. The company is going to launch just three rockets this calendar year: the classified NROL-68 mission on a Delta IV Heavy rocket in June, the “Silentbarker” mission for the National Reconnaissance Office on an Atlas V in September, and two Project Kuiper satellites for Amazon on an Atlas V in October.

That is the company’s lowest total number of launches since its founding in 2006, when the rocket businesses of Lockheed Martin and Boeing were merged.

Part of the reason for the low total is that United Launch Alliance is undergoing a transition from its historical fleet of Delta and Atlas rockets to Vulcan, which is intended to be more price competitive with other commercial offerings, such as SpaceX’s Falcon 9 and Falcon Heavy rockets. There will be a lot of demand for Vulcan once it starts flying regulary.

However, another factor is that the lower cost and equally reliable Falcon rockets have taken commercial and government launch business away from United Launch Alliance. SpaceX has steadily ascended over the last decade as United Launch Alliance has struggled to compete.

Whereas Bruno’s company launched just three rockets in 2023, on a handful of occasions SpaceX has launched three rockets in three days during this calendar year. SpaceX is likely to end the year with between 95 and 100 total launches.

ULA chief says Vulcan rocket will slip to 2024 after ground system issues Read More »

why-scientists-are-making-transparent-wood

Why scientists are making transparent wood

Science, syndication, transparent displays / /

a potential sustainable material —

The material is being exploited for smartphone screens, insulated windows, and more.

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a transparent piece of wood on top of a green leaf

Enlarge / See-through wood has a number of interesting properties that researchers hope to exploit.

Thirty years ago, a botanist in Germany had a simple wish: to see the inner workings of woody plants without dissecting them. By bleaching away the pigments in plant cells, Siegfried Fink managed to create transparent wood, and he published his technique in a niche wood technology journal. The 1992 paper remained the last word on see-through wood for more than a decade, until a researcher named Lars Berglund stumbled across it.

Berglund was inspired by Fink’s discovery, but not for botanical reasons. The materials scientist, who works at KTH Royal Institute of Technology in Sweden, specializes in polymer composites and was interested in creating a more robust alternative to transparent plastic. And he wasn’t the only one interested in wood’s virtues. Across the ocean, researchers at the University of Maryland were busy on a related goal: harnessing the strength of wood for nontraditional purposes.

Now, after years of experiments, the research of these groups is starting to bear fruit. Transparent wood could soon find uses in super-strong screens for smartphones; in soft, glowing light fixtures; and even as structural features, such as color-changing windows.

“I truly believe this material has a promising future,” says Qiliang Fu, a wood nanotechnologist at Nanjing Forestry University in China who worked in Berglund’s lab as a graduate student.

Wood is made up of countless little vertical channels, like a tight bundle of straws bound together with glue. These tube-shaped cells transport water and nutrients throughout a tree, and when the tree is harvested and the moisture evaporates, pockets of air are left behind. To create see-through wood, scientists first need to modify or get rid of the glue, called lignin, that holds the cell bundles together and provides trunks and branches with most of their earthy brown hues. After bleaching lignin’s color away or otherwise removing it, a milky-white skeleton of hollow cells remains.

This skeleton is still opaque, because the cell walls bend light to a different degree than the air in the cell pockets does—a value called a refractive index. Filling the air pockets with a substance like epoxy resin that bends light to a similar degree to the cell walls renders the wood transparent.

The material the scientists worked with is thin—typically less than a millimeter to around a centimeter thick. But the cells create a sturdy honeycomb structure, and the tiny wood fibers are stronger than the best carbon fibers, says materials scientist Liangbing Hu, who leads the research group working on transparent wood at the University of Maryland in College Park. And with the resin added, transparent wood outperforms plastic and glass: In tests measuring how easily materials fracture or break under pressure, transparent wood came out around three times stronger than transparent plastics like Plexiglass and about 10 times tougher than glass.

“The results are amazing, that a piece of wood can be as strong as glass,” says Hu, who highlighted the features of transparent wood in the 2023 Annual Review of Materials Research.

The process also works with thicker wood but the view through that substance is hazier because it scatters more light. In their original studies from 2016, Hu and Berglund both found that millimeter-thin sheets of the resin-filled wood skeletons let through 80 to 90 percent of light. As the thickness gets closer to a centimeter, light transmittance drops: Berglund’s group reported that 3.7-millimeter-thick wood—roughly two pennies thick—transmitted only 40 percent of light.

The slim profile and strength of the material means it could be a great alternative to products made from thin, easily shattered cuts of plastic or glass, such as display screens. The French company Woodoo, for example, uses a similar lignin-removing process in its wood screens, but leaves a bit of lignin to create a different color aesthetic. The company is tailoring its recyclable, touch-sensitive digital displays for products, including car dashboards and advertising billboards.

But most research has centered on transparent wood as an architectural feature, with windows a particularly promising use, says Prodyut Dhar, a biochemical engineer at the Indian Institute of Technology Varanasi. Transparent wood is a far better insulator than glass, so it could help buildings retain heat or keep it out. Hu and colleagues have also used polyvinyl alcohol, or PVA—a polymer used in glue and food packaging—to infiltrate the wood skeletons, making transparent wood that conducts heat at a rate five times lower than that of glass, the team reported in 2019 in Advanced Functional Materials.

Why scientists are making transparent wood Read More »

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Worm’s rear end develops its own head, wanders off to mate

Biology, developmental biology, Science, worms / /

Butt what? —

The butt even grows its own eyes, antennae, and brain.

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Three images of worm-like organisms.

Enlarge / From left to right, the head of an actual worm, and the stolon of a male and female.

Some do it horizontally, some do it vertically, some do it sexually, and some asexually. Then there are some organisms that would rather grow a butt that develops into an autonomous appendage equipped with its own antennae, eyes, and brain. This appendage will detach from the main body and swim away, carrying gonads that will merge with those from other disembodied rear ends and give rise to a new generation.

Wait, what in the science fiction B-movie alien star system is this thing?

Megasyllis nipponica really exists on Earth. Otherwise known as the Japanese green syllid worm, it reproduces by a process known as stolonization, which sounds like the brainchild of a sci-fi horror genius but evolved in some annelid (segmented) worms to give future generations the best chance at survival. What was still a mystery (until now) was exactly how that bizarre appendage, or stolon, could form its own head in the middle of the worm’s body. Turns out this is a wonder of gene regulation.

Butt how?

Led by evolutionary biologist and professor Toru Miura of the University of Tokyo, a team of scientists discovered the genetic mechanism behind the formation of the stolon. It starts with Hox genes. These are a set of genes that help determine which segments of an embryo will become the head, thorax, abdomen, and so on. In annelid worms like M. nipponica, different Hox genes regulate the segments that make up the worm’s entire body.

Miura and his colleagues were expecting the activity of Hox genes to be different in the anterior and posterior of a worm. They found out that it is actually not the Hox genes that control the stolon’s segments but gonad development that alters their identity. “These findings suggest that during stolonization, gonad development induces the head formation of a stolon, without up-regulation of anterior Hox genes,” the team said in a study recently published in Scientific Reports.

The anterior part, or stock, of M. nipponica is neither male nor female. The worm has organs called gonad primordia on the underside of its posterior end. When the primordia start maturing into oocytes or testes, head-formation genes (different from the Hox genes), which are also responsible for forming a head in other creatures, become active in the middle of the stock body.

This is when the stolon starts to develop a head. Its head grows a cluster of nerve cells that serve as a brain, along with a central nervous system that extends throughout its body. The stolon’s own eyes, antennae, and swimming bristles also emerge.

Left behind

Before a stolon can take off on its own, it has to develop enough to be fully capable of swimming autonomously and finding its way to another stolon of the opposite sex. The fully developed stolon appears like an alien being attached to the rest of the worm’s body. Besides its own nervous system and something comparable to a brain, it also has two pairs of bulging eyes, two pairs of antennae, and its own digestive tube. Those eyes are enlarged for a reason, as the gonad will often need to navigate in murky waters.

The antennae of the stolon can sense the environment around them, but the researchers suggest that they have a more important function—picking up on pheromones released by the opposite sex. The stolon still isn’t an exact duplication of the stock. It doesn’t have some of the worm’s most sophisticated features, such as a digestive tube with several specialized regions, probably because its purpose is exclusively to spawn. It dies off soon after.

So what could have made stolonization evolve in the first place? Further research needs to be done, but for now, it is thought that this strange capability might have shown up in some annelid worms when genes that develop the head shifted further down the body, but why this shifting of genes evolved to begin with is still unknown.

The worm also regenerates stolons at a high rate, which may also give it the best chance at propagating its species. Hold onto your butts.

Scientific Reports, 2023.  DOI:  10.1038/s41598-023-46358-8

Worm’s rear end develops its own head, wanders off to mate Read More »

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Marbled paper, frosty fireworks among 2023 Gallery of Fluid Motion winners

fluid dynamics, gallery of fluid motion, Physics, Science, science and art / /
Harvard University graduate student Yue Sun won a Milton Van Dyke Award for her video on the hydrodynamics of marbled paper.

Enlarge / Harvard University graduate student Yue Sun won a Milton Van Dyke Award for her video on the hydrodynamics of marbled paper.

Y. Sun/Harvard University et al.

Marbled paper is an art form that dates back at least to the 17th century, when European travelers to the Middle East brought back samples and bound them into albums. Its visually striking patterns arise from the complex hydrodynamics of paint interacting with water, inspiring a winning video entry in this year’s Gallery of Fluid Motion.

The American Physical Society’s Division of Fluid Dynamics sponsors the gallery each year as part of its annual meeting, featuring videos and posters submitted by scientists from all over the world. The objective is to highlight “the captivating science and often breathtaking beauty of fluid motion” and to “celebrate and appreciate the remarkable fluid dynamics phenomena unveiled by researchers and physicists.”

The three videos featured here are the winners of the Milton Van Dyke Awards, which also included three winning posters. There were three additional general video winners—on the atomization of impinging jets, the emergent collective motion of condensate droplets, and the swimming motion of a robotic eel—as well as three poster winners. You can view all the 2023 entries (winning and otherwise) here.

The hydrodynamics of marbling art

Harvard University graduate student Yue Sun was fascinated by the process and the resulting patterns of making marbled paper, particularly the randomness. “You don’t really know what you’re going to end up with until you have it printed,” she told Physics Magazine.

Although there are several different methods for marbling paper, the most common involves filling a shallow tray with water, then painstakingly applying different ink or paint colors to the water’s surface with an ink brush to cover the surface with concentric circles. Adding surfactants makes the colors float so that they can be stirred—perhaps with a very fine human hair—or fanned out by blowing on the circles of ink or paint with a straw. The final step is to lay paper on top to capture the colorful floating patterns. (Body marbling relies on a similar process, except the floating patterns are transferred onto a person’s skin.)

Sun was curious about the hydrodynamics at play and explored two key questions in the simulations for the video. Why does the paint or ink float despite being denser than the liquid bath? And why don’t the colors mix together to create new colors when agitated or stirred? The answer to the former is basically “surface tension,” while the latter does not occur because the bath is too viscous, so the diffusion of the paint or ink colors across color boundaries happens too slowly for mixing. Sun hopes to further improve her simulations of marbling in hopes of reverse-engineering some of her favorite patterns to determine which tools and movements were used to create them.

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A locally grown solution for period poverty

agave, agriculture, materials science, Science, Sustainability / /

Absorbant agave —

A Kenyan tinkerer and Stanford engineer team up to make maxi pads from agave fibers.

–

Image of rows of succulents with long spiky leaves and large flower stalks.

Enlarge / Sisal is an invasive species that is also grown agriculturally.

Women and girls across much of the developing world lack access to menstrual products. This means that for at least a week or so every month, many girls don’t go to school, so they fall behind educationally and often never catch up economically. 

Many conventional menstrual products have traditionally been made of hydrogels made from toxic petrochemicals, so there has been a push to make them out of biomaterials. But this usually means cellulose from wood, which is in high demand for other purposes and isn’t readily available in many parts of the globe. So Alex Odundo found a way to solve both of these problems: making maxi pads out of sisal, a drought-tolerant agave plant that grows readily in semi-arid climates like his native Kenya.

Putting an invasive species to work

Sisal is an invasive plant in rural Kenya, where it is often planted as livestock fencing and feedstock. It doesn’t require fertilizer, and its leaves can be harvested all year long over a five- to seven-year span. Odundo and his partners in Manu Prakash’s lab at Stanford University developed a process to generate soft, absorbent material from the sisal leaves. It relies on treatment with dilute peroxyformic acid (1 percent) to increase its porosity, followed by washing in sodium hydroxide (4 percent) and then spinning in a tabletop blender to enhance porosity and make it softer. 

They tested their fibers with a mixture of water mixed with glycerol—to make it thicker, like blood—and found that it is as absorbent as the cotton used in commercially available maxi pads. It was also as absorbent as wood pulp and more absorbent than fibers prepared from other biomaterials, including hemp and flax. Moreover, their process is less energy-intensive than conventional processing procedures, which are typically performed at higher temperatures and pressures. 

In a cradle-to-gate carbon footprint life cycle analysis, including sisal cultivation, harvesting, manufacturing, and transportation, sisal cellulose microfiber production fared roughly the same as production of cellulose microfiber from wood and much better than that from cotton in terms of both carbon footprint and water consumption, possibly because cotton requires so much upstream fertilizer. Much of the footprint comes from transportation, highlighting how useful it can be to make products like this in the same communities that need them.

Science for the greater good

This is not Odundo’s first foray into utilizing sisal; at Olex Techno Enterprises in Kisumu, Kenya, he has been making machines to turn sisal leaves into rope for over 10 years. This benefits local farmers since sisal rope and even sisal fibers sell for ten times as much as sisal leaves. In addition to making maxi pads, Odundo also built a stove that burns sawdust, rice husks, and other biodegradable waste products. 

By reducing wood stoves, he is reducing deforestation and improving the health of the women who breathe in the smoke of the cookfires. Adoption of such stoves have been a goal of environmentalists for years, and although a number of prototypes have been developed by mostly male engineers in developed countries, they have not been widely used because they are not that practical or appealing to the mostly female cooks in developing countries—the people who actually need to cook with them, yet were not consulted in their design.

Manu Prakash’s lab’s website proclaims that “we are dedicated toward inventing and distributing ‘frugal science’ tools to democratize access to science.” Partnering with Alex Odundo to manufacture menstrual products in the low-income rural communities that most need them seems like the apotheosis of that goal.

Communications Engineering, 2023. DOI:  10.1038/s44172-023-00130-y

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The quest to turn basalt dust into a viable climate solution

carbon capture, climate adaptation, climate adaptation strategies, Science, syndication / /
The quest to turn basalt dust into a viable climate solution

Mary Yap has spent the last year and a half trying to get farmers to fall in love with basalt. The volcanic rock is chock full of nutrients, captured as its crystal structure forms from cooling magma, and can make soil less acidic. In that way it’s like limestone, which farmers often use to improve their soil. It’s a little more finicky to apply, and certainly less familiar. But basalt also comes with an important side benefit: It can naturally capture carbon from the atmosphere.

Yap’s pitch is part of a decades-long effort to scale up that natural weathering process and prove that it can lock carbon away for long enough to make a different to the climate. “The bottleneck is getting farmers to want to do this,” Yap says.

On Thursday, Yap’s young startup, Lithos Carbon, got a $57.1 million boost for its quest to turn basalt dust into a viable climate solution. It came from Frontier, a benefit corporation backed by a consortium of companies aiming to finance promising approaches to carbon dioxide removal, or CDR. Lithos says it will use the funds to soak up 154,000 tons of CO2 by 2028, by sprinkling basalt dust on thousands of acres of US farmland. The average US car emits about 4 tons of CO2 each year.

The carbon removal purchase is the largest yet by Frontier, which was formed last year with nearly $1 billion from its tech-dominated members. Many of those companies, which include Meta, Alphabet, and payments processor Stripe, which owns Frontier, have made climate pledges that require not only reducing the emissions from their operations and supply chains but also “negative emissions”—sucking up carbon from the atmosphere to cancel out other emissions.

That accounting trick has been easier to prove out on paper than in practice. Many companies would have once turned to buying carbon offsets from activities like protecting forests that would otherwise be felled. But some have been trying to move away from those scandal-plagued and often short-lived approaches and into more durable techniques for carbon removal.

The current options for companies seeking negative emissions are limited. Frontier’s purchases are essentially down payments on ideas that are still in their infancy—generally too hard to verify or too expensive, or both, to attract a significant customer base. “What we’re trying to evaluate the field on is whether it’s on the trajectory to get to climate-relevant scale,” says Nan Ransohoff, who leads Frontier and also climate work at Stripe. The group starts with small “prepurchases” meant to help promising startups, and then moves on to “offtake” agreements for larger amounts of carbon that its members can count toward their emissions goals.

The Lithos purchase is one of those larger deals. It prices carbon removals at $370 per ton, about a quarter of which will pay for field monitoring and modeling to verify that carbon is being sequestered away from the atmosphere for the long term. Ransohoff says Frontier believes that Lithos is on a path to its goal of removing CO2 for customers at a cost of less than $100 per ton, and at a rate of at least a half a billion tons per year.

“Most promising” approach

Lithos, founded in 2022, is developing a technology called enhanced rock weathering. It involves spreading a fine dust of basalt across fields before planting. As the rock further weathers from rainfall, it reacts with CO2 in the air. That forms bicarbonate, which locks away the carbon by combining it with hydrogen and oxygen atoms. Ultimately, the compound is washed into the ocean, where the carbon should stay put.

The strategy has the benefit of piggybacking on things that humans already do, Yap says. That’s in contrast with techniques like direct air capture, which involves building industrial plants that suck carbon out of the atmosphere. It’s easy to measure carbon removed that way—it’s all captured there onsite—but critics say it will be difficult to scale up because removing enough carbon to make a difference will require thousands of dedicate, resource-intensive facilities.

Using basalt dust to capture carbon should be more easily scaled up. There are plenty of fields to dump rock dust onto, and plenty of water for carbon to end up in. But the distributed nature of the process also makes measuring how much carbon was actually removed from the atmosphere more difficult.

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Hubble back in service after gyro scare—NASA still studying reboost options

Hubble Space Telescope, NASA, Science, Space, spacex / /
The Hubble Space Telescope viewed from Space Shuttle Atlantis during a servicing mission in 2009.

Enlarge / The Hubble Space Telescope viewed from Space Shuttle Atlantis during a servicing mission in 2009.

NASA

The Hubble Space Telescope resumed science observations on Friday after ground teams spent most of the last three weeks assessing the performance of a finicky gyroscope, NASA said.

The troublesome gyroscope is a critical part of the observatory’s pointing system. Hubble’s gyros measure how fast the spacecraft is turning, helping the telescope aim its aperture toward distant cosmic wonders.

Hubble still provides valuable scientific data for astronomers nearly 34 years since its launch aboard NASA’s Space Shuttle Discovery in 1990. Five more shuttle servicing missions repaired Hubble, upgraded its science instruments, and replaced hardware degraded from long-term use in space. Among other tasks, astronauts on the last of the shuttle repair flights in 2009 installed six new gyroscopes on Hubble.

Moving parts sometimes break

The gyros have long been one of the parts of Hubble that require the most upkeep. A wheel inside each gyro spins at a constant rate of 19,200 revolutions per minute, and the wheel is, in turn, sealed inside a cylinder suspended in a thick fluid, according to NASA. Electronics within each gyro detect very small movements of the axis of the wheel, which supply Hubble’s central computer with information about the spacecraft’s turn rate. Hair-thin wires route signals from the gyroscopes, and these wires can degrade over time.

Three of the six gyros installed on Hubble in 2009 have failed, and three others remain operational. The three still-functioning gyros are based on a newer design for longer life, but one of these units has shown signs of wear in the last few months. This gyroscope, designated Gyro 3, has always exhibited “consistent noisy behavior,” said Pat Crouse, Hubble project manager at NASA’s Goddard Space Flight Center.

Hubble typically needs three gyros to operate normally, so ground controllers shut down Gyro 3 for roughly seven years until Hubble needed it in 2018, when another gyroscope failed, leaving only three of the devices still working.

“Back in August, we saw issues,” Crouse told Ars this week. “It would sort of sporadically output some rate information that was not consistent with the observed spacecraft body rates, but it was short-lived, and we were characterizing what that performance was like and how much we could tolerate.”

The gyro’s performance worsened in November when it fed Hubble’s control system erroneous data. The gyroscope sensed that the spacecraft was changing its orientation when it really wasn’t moving. “That, then, contributed to an error in attitude that was kind of causing a little bit of drift,” Crouse said.

Automated software on Hubble detected the errors and put the spacecraft into “safe mode” two times last month. Hubble quickly resumed science observations each time but then went into safe mode again on November 23. Hubble managers took some extra time to gather data on the gyro’s health. Engineers commanded Hubble to move back and forth, and the suspect gyro consistently seemed to work well.

Hubble back in service after gyro scare—NASA still studying reboost options Read More »