research

researchers-show-that-training-on-“junk-data”-can-lead-to-llm-“brain-rot”

Researchers show that training on “junk data” can lead to LLM “brain rot”

On the surface, it seems obvious that training an LLM with “high quality” data will lead to better performance than feeding it any old “low quality” junk you can find. Now, a group of researchers is attempting to quantify just how much this kind of low quality data can cause an LLM to experience effects akin to human “brain rot.”

For a pre-print paper published this month, the researchers from Texas A&M, the University of Texas, and Purdue University drew inspiration from existing research showing how humans who consume “large volumes of trivial and unchallenging online content” can develop problems with attention, memory, and social cognition. That led them to what they’re calling the “LLM brain rot hypothesis,” summed up as the idea that “continual pre-training on junk web text induces lasting cognitive decline in LLMs.”

Figuring out what counts as “junk web text” and what counts as “quality content” is far from a simple or fully objective process, of course. But the researchers used a few different metrics to tease a “junk dataset” and “control dataset” from HuggingFace’s corpus of 100 million tweets.

Since brain rot in humans is “a consequence of Internet addiction,” they write, junk tweets should be ones “that can maximize users’ engagement in a trivial manner.” As such, the researchers created one “junk” dataset by collecting tweets with high engagement numbers (likes, retweets, replies, and quotes) and shorter lengths, figuring that “more popular but shorter tweets will be considered to be junk data.”

For a second “junk” metric, the researchers drew from marketing research to define the “semantic quality” of the tweets themselves. Using a complex GPT-4o prompt, they sought to pull out tweets that focused on “superficial topics (like conspiracy theories, exaggerated claims, unsupported assertions or superficial lifestyle content)” or that had an “attention-drawing style (such as sensationalized headlines using clickbait language or excessive trigger words).” A random sample of these LLM-based classifications was spot-checked against evaluations from three graduate students with a 76 percent matching rate.

Researchers show that training on “junk data” can lead to LLM “brain rot” Read More »

“things-we’ll-never-know”-science-fair-highlights-us’s-canceled-research

“Things we’ll never know” science fair highlights US’s canceled research


Congressional Democrats host scientists whose grants have been canceled.

Like a research conference, but focused on research that may never happen now. Credit: John Timmer

Washington, DC—From a distance, the gathering looked like a standard poster session at an academic conference, with researchers standing next to large displays of the work they were doing. Except in this case, it was taking place in the Rayburn House Office Building on Capitol Hill, and the researchers were describing work that they weren’t doing. Called “The things we’ll never know,” the event was meant to highlight the work of researchers whose grants had been canceled by the Trump administration.

A lot of court cases have been dealing with these cancellations as a group, highlighting the lack of scientific—or seemingly rational—input into the decisions to cut funding for entire categories of research. Here, there was a much tighter focus on the individual pieces of research that had become casualties in that larger fight.

Seeing even a small sampling of the individual grants that have been terminated provides a much better perspective on the sort of damage that is being done to the US public by these cuts and the utter mindlessness of the process that’s causing that damage.

“It’s no way to do science,” one of the researchers told us.

Targeting diversity and more

While many of the scientists were perfectly willing to identify themselves at the event, more than one asked us not to name them in any coverage. Another noted that, while she wasn’t concerned about retaliation from the federal government, she was at a state university in a state with a Republican governor and so could still face problems. As a result, we’re not identifying any of the scientists we talked to in this article.

With a few exceptions, most of these scientists could only surmise why their research was cut. A couple of them were funded by programs that were meant to increase minority participation in the sciences and so were targeted as DEI. Another was at Harvard and saw his materials science research into new refrigerants canceled, ostensibly because Harvard hadn’t cracked down hard enough on campus antisemitism (“ostensibly” because the government has also issued a series of demands that have nothing to do with antisemitism).

In their rush to terminate grants, each agency settled on a single form letter that told researchers that their work was being defunded because it no longer reflected agency priorities. A number of said researchers surmised that they lost their support because, at the time the grant was initially funded, many federal agencies required attempts to, as the National Science Foundation termed it, “broaden participation.” This left them at risk of falling afoul of the new administration’s anti-DEI efforts.

A few of them planned to eliminate the language they suspect offended DOGE and send in a new grant request. But, given the lack of details in the termination letters, all of them would have to guess as to the problem. And at least one said that the entire program that had funded her grant had since been eliminated, so this wasn’t even an option.

Many of the grants were focused on STEM education, and it’s extremely difficult to imagine that people will be better off without the work happening. One involved figuring out how to better incorporate instruction in quantum mechanics into high school and college education, rather than limiting this increasingly important topic to a handful of physics specialists. Another was focused on trying to help engineers communicate better with the communities that would ultimately use the things they were designing (she cited Google Glass and the Segway as examples of the problems that result when this doesn’t happen).

A large multi-university collaboration had put together a program to help deaf students navigate careers in science, providing support at the undergraduate, graduate, and post-doctoral levels. The effort received multiple grants from different sources, but a number were part of a diversifying science effort, and all of those have been cut.

For a couple of the researchers present, the damage being done to the educational pipeline was personal: they had received prestigious grants that are intended to ease the transition between post-doctoral training and starting a faculty job. This funding helps them stay in a post-doctoral position long enough to develop a solid research program, then partially funds the process of starting up a lab to pursue that program. But for these researchers, the rug had been pulled out from under them partway through the process—funding that was cut even though (in one case) they were simply studying the regeneration of the retina in an experimental organism.

Pandemics, misinformation, and confusion

The damage is far from limited to education and diversity issues. Despite having been in power during a pandemic that ultimately killed well over a million Americans, the administration has decided that any pandemic-related work is not a priority. So, an entire pandemic preparedness program was scrapped. A pair of researchers was there to talk about the Antiviral Drug Discovery program (AViDD), which had been funded to develop drugs that target various emerging viral threats, such as coronaviruses and the families that include Ebola, Zika, and measles. The idea behind AViDD is to have treatments ready that could limit the spread of any new, threatening version of these viruses in order to give us time to develop vaccines.

AViDD had been funded to the tune of $1.2 billion, included nine dedicated research centers, and involved researchers at 90 institutions. In total, it had spent about half that money in developing 35 treatment candidates that targeted seven different viral families. And then the funding for the entire program was eliminated before any of those candidates could be pursued any further—the researchers likened it to building half a bridge.

Another area that has been targeted is misinformation research. One small team included an academic who’s also a Reddit moderator; they trained an AI model to flag posts that might require moderator intervention, potentially cutting down on the workload of human moderators, who are often volunteers. The project had gotten to the point where they were looking for a company willing to test the system on some user-generated discussions it hosted; now it’s on indefinite hold.

In other instances, it was hard to tell what had triggered the elimination of funding. One team was developing baseline data to allow us to track the presence of antibiotic resistance genes in municipal wastewater, which could be useful for various public health measures. It’s not entirely clear why that funding was canceled—possibly it was considered pandemic-related? The same uncertainty applies to a group of researchers who were trying to develop methods to identify which Arctic infrastructure projects would benefit the most people in Alaska. The researchers involved suspect their efforts to engage native communities probably triggered DOGE’s DEI filters, but they received the same form letter as everyone else.

Even when it was obvious why a given bit of research was cut, it didn’t feel any less stupid. One grant that was targeted funded research on prostate cancer in African Americans, which undoubtedly set off diversity alarms. But the researcher who had received it highlighted that, because of a complicated mix of genetics, environmental exposures, and occupational risks, prostate cancer is diagnosed at a 76 percent higher rate in African Americans, and they die because of it at twice the rate of whites. By stopping this sort of research, we’re committing to perpetuating these disparities, despite the administration’s rhetoric of eliminating racial preferences.

No way to do science

Although the likely loss of a large amount of interesting science is obviously a major problem, in many ways the uncertainty is worse. A number of the people there had seen funding restored due to temporary restraining orders issued in response to a number of lawsuits. But they couldn’t be confident that the money wouldn’t go away again due to a different ruling during the appeals process. And, even if they were to prevail in the courts on the initial cancellation, there were already fears that the government would think of some other justification to try to take the money away a second time.

The uncertainty makes it impossible to plan any significant distance ahead or hire anyone to do the work for longer-term projects. Many researchers are starting to write grants targeting non-federal funding sources, increasing the competition for that money and making it less likely that the effort will have any payoff.

Looming over all of this are the huge research cuts in the recently passed budget, which will cripple many of the agencies involved here starting in the next fiscal year. This raises questions about how much of this money might ever come back, even if the grants were reformulated to get past whatever issue got them cut.

Is there anything to be done? The event was being put on by the Democrats on the House Science Committee, and one of their members tried to offer some hope for the long-term situation. “Many of us on this committee are going to fight to claw back some of these cuts,” said Representative April McClain Delaney of Maryland. But that would require some cooperation with Republicans in the House and Senate, who hold a decisive number of votes and have so far seemed comfortable with the cuts to science funding. And they’d need to find a bill to attach it to that Trump would feel compelled to sign.

But that’s the future. For now, nobody offered much hope for the grants that are currently being targeted—after all, Congress had already given the federal government the money and, in many cases, directed it to spend it on these issues. At this point, the most scientists can hope for is that the US legal system ultimately acknowledges that the decision to cut their funding runs afoul of these congressional directives. And that may take years to be resolved.

Photo of John Timmer

John is Ars Technica’s science editor. He has a Bachelor of Arts in Biochemistry from Columbia University, and a Ph.D. in Molecular and Cell Biology from the University of California, Berkeley. When physically separated from his keyboard, he tends to seek out a bicycle, or a scenic location for communing with his hiking boots.

“Things we’ll never know” science fair highlights US’s canceled research Read More »

trump-administration-cuts-off-all-future-federal-funding-to-harvard

Trump administration cuts off all future federal funding to Harvard

The ongoing war between the Trump administration and Harvard University has taken a new twist, with the government sending Harvard a letter that, amid what appears to be a stream-of-consciousness culture war rant, announces that the university will not be receiving any further research grants. The letter potentially suggests that Harvard could see funding restored by “complying with long-settled Federal Law,” but earlier demands from the administration included conditions that went well beyond those required by law.

The letter, sent by Secretary of Education Linda McMahon, makes it somewhat difficult to tell exactly what the government wants, because most of the text is a borderline deranged rant written in florid MAGA-ese. You don’t have to go beyond the first paragraph to get a sense that this is less a setting of funding conditions than an airing of grievances:

Instead of using these funds to advance the education of its students, Harvard is engaging in a systemic pattern of violating federal law. Where do many of these “students” come from, who are they, how do they get into Harvard, or even into our country—and why is there so much HATE? These are questions that must be answered, among many more, but the biggest question of all is, why will Harvard not give straightforward answers to the American public?

Does Harvard have to answer these questions to get funding restored? It’s unclear.

From there, the letter changes topic so often that it gets difficult to remember that billions of dollars of funding to some of the world’s most prominent researchers is at stake. On the first page alone, the letter complains that a math class Harvard set up to handle COVID-driven gaps in incoming students’ math skills is a remedial course that shouldn’t be needed, given the university’s supposedly high standards. The resignation of Harvard’s former president, as well as its faculty hires, also make appearances. (Said hires being compared to “Hiring the captain of the Titanic to teach navigation.”)

Trump administration cuts off all future federal funding to Harvard Read More »

trump-admin-accused-of-censoring-nih’s-top-expert-on-ultra-processed-foods

Trump admin accused of censoring NIH’s top expert on ultra-processed foods

Hall claims that because of this, aides for Kennedy blocked him from being directly interviewed by New York Times reporters about the study. Instead, Hall was allowed to provide only written responses to the newspaper. However, Hall claims that Andrew Nixon, a spokesperson for Kennedy, then downplayed the study’s results to the Times and edited Hall’s written responses and sent them to the reporter without Hall’s consent.

Further, Hall claims he was barred from presenting his research on ultra-processed foods at a conference and was forced to either edit a manuscript he had worked on with outside researchers or remove himself as a co-author.

An HHS spokesperson denied to CBS that Hall was censored or that his written responses to the Times were edited. “Any attempt to paint this as censorship is a deliberate distortion of the facts,” a statement from the HHS said.

In response, Hall wrote to CBS, “I wonder how they define censorship?”

Hall said he had reached out to NIH leadership about his concerns in hopes it all was an “aberration” but never received a response.

“Without any reassurance there wouldn’t be continued censorship or meddling in our research, I felt compelled to accept early retirement to preserve health insurance for my family,” he wrote in the LinkedIn post. “Due to very tight deadlines to make this decision, I don’t yet have plans for my future career.”

Trump admin accused of censoring NIH’s top expert on ultra-processed foods Read More »

trump-administration’s-attack-on-university-research-accelerates

Trump administration’s attack on university research accelerates

Shortly after its inauguration, the Trump administration has made no secret that it isn’t especially interested in funding research. Before January’s end, major science agencies had instituted pauses on research funding, and grant funding has not been restored to previous levels since. Many individual grants have been targeted on ideological grounds, and agencies like the National Science Foundation are expected to see significant cuts. Since then, individual universities have been targeted, starting with an ongoing fight with Columbia University over $400 million in research funding.

This week, however, it appears that the targeting of university research has entered overdrive, with multiple announcements of funding freezes targeting several universities. Should these last for any considerable amount of time, they will likely cripple research at the targeted universities.

On Wednesday, Science learned that the National Institutes of Health has frozen all of its research funding to Columbia, despite the university agreeing to steps previously demanded by the administration and the resignation of its acting president. In 2024, Columbia had received nearly $700 million in grants from the NIH, with the money largely going to the university’s prestigious medical and public health schools.

But the attack goes well beyond a single university. On Tuesday, the Trump administration announced a hold on all research funding to Northwestern University (nearly $800 million) and Cornell University ($1 billion). These involved money granted by multiple government agencies, including a significant amount from the Department of Defense in Cornell’s case. Ostensibly, all of these actions were taken because of the university administrators’ approach to protests about the conflict in Gaza, which the administration has characterized as allowing antisemitism.

Trump administration’s attack on university research accelerates Read More »

report:-us-scientists-lost-$3-billion-in-nih-grants-since-trump-took-office

Report: US scientists lost $3 billion in NIH grants since Trump took office

Since Trump took office on January 20, research funding from the National Institutes of Health has plummeted by more than $3 billion compared with the pace of funding in 2024, according to an analysis by The Washington Post.

By this time in March 2024, the NIH had awarded US researchers a total of $1.027 billion for new grants or competitive grant renewals. This year, the figure currently stands at about $400 million. Likewise, funding for renewals of existing grants without competition reached $4.5 billion by this time last year, but has only hit $2 billion this year. Together, this slowdown amounts to a 60 percent drop in grant support for a wide variety of research—from studies on cancer treatments, diabetes, Alzheimer’s, vaccines, mental health, transgender health, and more.

The NIH is the primary source of funding for biomedical research in the US. NIH grants support more than 300,000 scientists at more than 2,500 universities, medical schools, and other research organizations across all 50 states.

In the near term, the missing grant money means clinical trials have been abruptly halted, scientific projects are being shelved, supplies can’t be purchased, and experiments can’t be run. But, in the long run, it means a delay in scientific advancements and treatment, which could echo across future generations. With funding in question, academic researchers may be unable to retain staff or train younger scientists.

Report: US scientists lost $3 billion in NIH grants since Trump took office Read More »

“this-will-be-a-painful-period”:-rfk-jr-slashes-24%-of-us-health-dept.

“This will be a painful period”: RFK Jr. slashes 24% of US health dept.

Health Secretary and anti-vaccine advocate Robert F. Kennedy Jr. is slashing a total of 20,000 jobs across the Department of Health and Human Services—or about 24 percent of the workforce—in a sweeping overhaul said to improve efficiency and save money, Kennedy and the HHS announced Thursday.

Combining workforce losses from early retirement, the “Fork in the Road” deferred resignation deal, and 10,000 positions axed in the reductions and restructuring announced today, HHS will shrink from 82,000 full-time employees to 62,000 under Kennedy and the Trump administration. The HHS’s 28 divisions will be cut down to 15, while five of the department’s 10 regional offices will close.

“This will be a painful period,” Kennedy said in a video announcement posted on social media. Calling the HHS a “sprawling bureaucracy,” Kennedy claimed that the cuts would be aimed at “excess administrators.”

“I want to promise you now that we are going to do more with less,” he said in the video.

Kennedy and HHS said the cuts will save $1.8 billion each year. That’s about 0.027 percent of total federal spending, based on the $6.75 trillion the government spent in 2024, and about 0.06 percent of the $2.8 trillion HHS budget for that year.

The downsizing announced today includes significant cuts to the Food and Drug Administration, the Centers for Disease Control and Prevention, and the National Institutes of Health.

Cuts upon cuts

The FDA will lose 3,500 employees, which The Wall Street Journal reported was about 19 percent of its staff. HHS did not provide current staff levels at the agency level or percentage cuts. The CDC, which will absorb the Administration for Strategic Preparedness and Response (ASPR), will lose 2,400 employees (1,400 from CDC and 1,000 from ASPR). The Journal reported that to be about 18 percent of the total workforce. NIH will lose 1,200 employees, about 6 percent of its workers.

“This will be a painful period”: RFK Jr. slashes 24% of US health dept. Read More »

umass-disbands-its-entering-biomed-graduate-class-over-trump-funding-chaos

UMass disbands its entering biomed graduate class over Trump funding chaos

Many schools are now bracing for steep declines in support. At Duke University, administrators have implemented hiring freezes, scaled back research plans, and will cut the number of admitted biomedical PhD students by 23 percent or more, according to reporting by the Associated Press. The school took in $580 million in grants and contracts from the National Institutes of Health last year.

At Vanderbilt University, faculty were sent an email on February 6 instructing them to reduce graduate admissions by half across the board, according to Stat. The outlet also reported that faculty at the University of Washington’s School of Public Health have reduced admissions.

Faculty at the University of Pennsylvania also reported having to rescind admission offers to applicants and were directed to significantly reduce admission rates, according to The Daily Pennsylvanian. The University of Wisconsin-Madison, too, is shrinking its graduate programs, according to the WKOW.com.

Beth Sullivan, who oversees graduate programs at Duke, told the AP that the shrinking classes mean a shrinking pipeline into America’s medical research community, which dominates the world’s health research fields and is a significant force in the country’s economy. “Our next generation of researchers are now poised on the edge of this cliff, not knowing if there’s going to be a bridge that’s going to get them to the other side, or if this is it,” Sullivan said.

“This is a severe blow to science and the training of the next generation of scientists,” Siyuan Wang, a geneticist and cell biologist at the Yale School of Medicine in New Haven, Connecticut, told Nature. “With fewer scientists, there will be less science and innovation that drive societal progress and the improvement of public health.”

This post was updated to correct Rachael Sirianni’s job title.

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bogus-research-is-undermining-good-science,-slowing-lifesaving-research

Bogus research is undermining good science, slowing lifesaving research

In 2022, Byrne and colleagues, including two of us, found that suspect genetics research, despite not immediately affecting patient care, informs scientists’ work, including clinical trials. But publishers are often slow to retract tainted papers, even when alerted to obvious fraud. We found that 97 percent of the 712 problematic genetics research articles we identified remained uncorrected.

Potential solutions

The Cochrane Collaboration has a policy excluding suspect studies from its analyses of medical evidence and is developing a tool to spot problematic medical trials. And publishers have begun to share data and technologies among themselves to combat fraud, including image fraud.

Technology startups are also offering help. The website Argos, launched in September 2024 by Scitility, an alert service based in Sparks, Nevada, allows authors to check collaborators for retractions or misconduct. Morressier, a scientific conference and communications company in Berlin, offers research integrity tools. Paper-checking tools include Signals, by London-based Research Signals, and Clear Skies’ Papermill Alarm.

But Alam acknowledges that the fight against paper mills won’t be won as long as the booming demand for papers remains.

Today’s commercial publishing is part of the problem, Byrne said. Cleaning up the literature is a vast and expensive undertaking. “Either we have to monetize corrections such that publishers are paid for their work, or forget the publishers and do it ourselves,” she said.

There’s a fundamental bias in for-profit publishing: “We pay them for accepting papers,” said Bodo Stern, a former editor of the journal Cell and chief of Strategic Initiatives at Howard Hughes Medical Institute, a nonprofit research organization and funder in Chevy Chase, Maryland. With more than 50,000 journals on the market, bad papers shopped around long enough eventually find a home, Stern said.

To prevent this, we could stop paying journals for accepting papers and look at them as public utilities that serve a greater good. “We should pay for transparent and rigorous quality-control mechanisms,” he said.

Peer review, meanwhile, “should be recognized as a true scholarly product, just like the original article,” Stern said. And journals should make all peer-review reports publicly available, even for manuscripts they turn down.

This article is republished from The Conversation under a Creative Commons license. This is a condensed version. To learn more about how fraudsters around the globe use paper mills to enrich themselves and harm scientific research, read the full version.

Frederik Joelving is a contributing editor at Retraction Watch; Cyril Labbé is a professor of computer science at the Université Grenoble Alpes (UGA); and Guillaume Cabanac is a professor of computer science at Institut de Recherche en Informatique de Toulouse.

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trust-in-scientists-hasn’t-recovered-from-covid-some-humility-could-help.

Trust in scientists hasn’t recovered from COVID. Some humility could help.

Study 3 essentially replicated study 2, but with the tweak that the articles varied whether the fictional scientist was male or female, in case gendered expectations affected how people perceived humility and trustworthiness. The results from 369 participants indicated that gender didn’t affect the link between IH and trust. Similarly, in study 4, with 371 participants, the researchers varied the race/ethnicity of the scientist, finding again that the link between IH and trust remained.

“Together, these four studies offer compelling evidence that perceptions of scientists’ IH play an important role in both trust in scientists and willingness to follow their research-based recommendations,” the authors concluded.

Next steps

In the final study involving 679 participants, researchers examined different ways that scientists might express IH, including whether the IH was expressed as a personal trait, limitations of research methods, or as limitations of research results. Unexpectedly, the strategies to express IH by highlighting limitations in the methods and results of research both increased perceptions of IH, but shook trust in the research. Only personal IH successfully boosted perceptions of IH without backfiring, the authors report.

The finding suggests that more research is needed to guide scientists on how best to express high IH. But, it’s clear that low IH is not good. “[W]e encourage scientists to be particularly mindful of displaying low IH, such as by expressing overconfidence, being unwilling to course correct or disrespecting others’ views,” the researchers caution.

Overall, Schumann said she was encouraged by the team’s findings. “They suggest that the public understands that science isn’t about having all the answers; it’s about asking the right questions, admitting what we don’t yet understand, and learning as we go. Although we still have much to discover about how scientists can authentically convey intellectual humility, we now know people sense that a lack of intellectual humility undermines the very aspects of science that make it valuable and rigorous. This is a great place to build from.”

Trust in scientists hasn’t recovered from COVID. Some humility could help. Read More »

research-monkeys-still-having-a-ball-days-after-busting-out-of-lab,-policy-say

Research monkeys still having a ball days after busting out of lab, policy say

If you need any inspiration for cutting loose and relaxing this weekend, look no further than a free-wheeling troop of monkeys that broke out of their South Carolina research facility Wednesday and, as of noon Friday, were still “playfully exploring” with their newfound freedom.

In an update Friday, the police department of Yemassee, SC said that the 43 young, female rhesus macaque monkeys are still staying around the perimeter of the Alpha Genesis Primate Research Facility. “The primates are exhibiting calm and playful behavior, which is a positive indication,” the department noted.

The fun-loving furballs got free after a caretaker “failed to secure doors” at the facility.

Alpha Genesis staff have been keeping an eye on the escapees, trying to entice them back in with food. But, instead of taking the bait, the primates have been playing on the perimeter fence while still keeping in touch with the monkeys inside by cooing to them.

“They’re just being goofy monkeys jumping back and forth playing with each other,” Alpha Genesis CEO Greg Westergaard told CBS News Thursday. “It’s kind of like a playground situation here.”

Yemassee police note that the monkeys are very young and small—only about 6 or 7 pounds each. They have not been used for any testing yet, don’t carry any disease, and pose no health risk to the public. Still, area residents have been advised to keep their doors and windows locked in case the wee primates try to pay a visit.

This isn’t the first time—or even the second time—Alpha Genesis has had trouble keeping its monkeys under control. In 2018, the US Department of Agriculture fined the company $12,600 for violations between 2014 and 2016 that included four monkey breakouts. In those incidents, a total of 30 monkeys escaped. One was never found.

Research monkeys still having a ball days after busting out of lab, policy say Read More »

alzheimer’s-scientist-indicted-for-allegedly-falsifying-data-in-$16m-scheme

Alzheimer’s scientist indicted for allegedly falsifying data in $16M scheme

Funding Scheme —

The work underpinned an Alzheimer’s drug by Cassava, now in a Phase III trial.

Alzheimer’s scientist indicted for allegedly falsifying data in $16M scheme

A federal grand jury has indicted an embattled Alzheimer’s researcher for allegedly falsifying data to fraudulently obtain $16 million in federal research funding from the National Institutes of Health for the development of a controversial Alzheimer’s drug and diagnostic test.

Hoau-Yan Wang, 67, a medical professor at the City University of New York, was a paid collaborator with the Austin, Texas-based pharmaceutical company Cassava Sciences. Wang’s research and publications provided scientific underpinnings for Cassava’s Alzheimer’s treatment, Simufilam, which is now in Phase III trials.

Simufilam is a small-molecule drug that Cassava claims can restore the structure and function of a scaffolding protein in the brain of people with Alzheimer’s, leading to slowed cognitive decline. But outside researchers have long expressed doubts and concerns about the research.

In 2023, Science magazine obtained a 50-page report from an internal investigation at CUNY that looked into 31 misconduct allegations made against Wang in 2021. According to the report, the investigating committee “found evidence highly suggestive of deliberate scientific misconduct by Wang for 14 of the 31 allegations,” the report states. The allegations largely centered around doctored and fabricated images from Western blotting, an analytical technique used to separate and detect proteins. However, the committee couldn’t conclusively prove the images were falsified “due to the failure of Dr. Wang to provide underlying, original data or research records and the low quality of the published images that had to be examined in their place.”

In all, the investigation “revealed long-standing and egregious misconduct in data management and record keeping by Dr. Wang,” and concluded that “the integrity of Dr. Wang’s work remains highly questionable.” The committee also concluded that Cassava’s lead scientist on its Alzheimer’s disease program, Lindsay Burns, who was a frequent co-author with Wang, also likely bears some responsibility for the misconduct.

In March 2022, five of Wang’s articles published in the journal PLOS One were retracted over integrity concerns with images in the papers. Other papers by Wang have also been retracted or had statements of concern attached to them. Further, in September 2022, the Food and Drug Administration conducted an inspection of the analytical work and techniques used by Wang to analyze blood and cerebrospinal fluid from patients in a simufilam trial. The investigation found a slew of egregious problems, which were laid out in a “damning” report obtained by Science.

In the indictment last week, federal authorities were explicit about the allegations, claiming that Wang falsified the results of his scientific research to NIH “by, among other things, manipulating data and images of Western blots to artificially add bands [which represent proteins], subtract bands, and change their relative thickness and/or darkness, and then drawing conclusions” based on those false results.

Wang is charged with one count of major fraud against the United States, two counts of wire fraud, and one count of false statements. If convicted, he faces a maximum penalty of 10 years in prison for the major fraud charge, 20 years in prison for each count of wire fraud, and five years in prison for the count of false statements, the Department of Justice said in an announcement.

In a statement posted to its website, Cassava acknowledged Wang’s indictment, calling him a “former” scientific adviser. The company also said that the grants central to the indictment were “related to the early development phases of the Company’s drug candidate and diagnostic test and how these were intended to work.” However, Cassava said that Wang “had no involvement in the Company’s Phase 3 clinical trials of simufilam.”

Those ongoing trials, which some have called to be halted, are estimated to include over 1,800 patients across several countries.

Alzheimer’s scientist indicted for allegedly falsifying data in $16M scheme Read More »