health

Man shocks doctors with extreme blood pressure, stroke from energy drinks

blood pressure, caffeine, cardiovascular disease, case report, energy drinks, health, hypertension, stroke / Kris Guyer / December 12, 2025

Sometimes, downing an energy drink can feel like refueling your battery. But with too much, that jolt can turn into a catastrophic surge that fries the wiring and blows a fuse. That was the unfortunate and alarming case for a man in the UK several years ago, according to a case report this week in BMJ Case Reports.

The man, who was in his 50s and otherwise healthy, showed up at a hospital after the entire left side of his body abruptly went numb and he was left with clumsy, uncoordinated muscle movements (ataxia). His blood pressure was astonishingly high, at 254/150 mm Hg. For context, a normal reading is under 120/80, while anything over 180/120 is considered a hypertensive crisis, which is a medical emergency.

The man had suffered a mild stroke, and his extremely high blood pressure was an obvious factor. But why his blood pressure had reached stratospheric heights was far less obvious to his doctors, according to the retrospective case report written by Martha Coyle and Sunil Munshi of Nottingham University Hospital.

Upon examining the man, the doctors described him as fit and healthy. He didn’t smoke, drink, or use any drugs. His blood work was all completely normal. His cholesterol, blood sugar levels, markers for kidney and liver function—everything from routine tests came back normal. Specialized tests for things like autoimmune and clotting disorders were also negative. Heart tests found no problems. Urine tests and abdominal scans found no problems with his other organs.

Power surge

Still, a computed tomography (CT) scan of his head found evidence of spasms in arteries in his brain, which are strongly linked to high blood pressure. And magnetic resonance imaging (MRI) found an infarct (dead tissue) in his thalamus, a central, deep part of the brain, which, among many critical functions, relays sensory and motor signals. In all, it seemed his spasming arteries had cut off blood supply to this part of his brain, causing his stroke, subsequent numbness, and ataxia.

Man shocks doctors with extreme blood pressure, stroke from energy drinks Read More »

Senator endorses discredited doctor’s book that claims chemical treats autism, cancer

chlorine dioxide, Dr. Pierre Kory, health, jenna mccarthy, Sen. Ron Johnson / Paul Patrick / December 12, 2025

Safety experts advise those who handle chlorine dioxide to work in well-ventilated spaces, wear gloves.

Senator Ron Johnson (R-WI) gives a thumbs up to chlorine dioxide. Credit: Scott Olson

For years, Sen. Ron Johnson has been spreading conspiracy theories and misinformation about COVID-19 and the safety of vaccines.

He’s promoted disproven treatments for COVID-19 and claimed, without evidence, that athletes are “dropping dead on the field” after getting the COVID-19 vaccination. Now the Wisconsin politician is endorsing a book by a discredited doctor promoting an unproven and dangerous treatment for autism and a host of ailments: chlorine dioxide, a chemical used for disinfecting and bleaching.

The book is “The War on Chlorine Dioxide: The Medicine that Could End Medicine” by Dr. Pierre Kory, a critical care specialist who practiced in Wisconsin hospitals before losing his medical certification for statements advocating using an antiparasite medication to treat COVID-19. The action, he’s said, makes him unemployable, even though he still has a license.

Kory has said there’s a globally coordinated campaign by public health agencies, the drug industry, and the media to suppress evidence of the medicinal wonders of chlorine dioxide. His book, according to its website, contends that the “remarkable molecule” works “to treat everything from cancer and malaria to autism and COVID.”

The book jacket features a prominent blurb from Johnson calling the doctor’s treatise: “A gripping tale of corruption and courage that will open eyes and prompt serious questions.”

Chlorine dioxide is a chemical compound that has a range of applications, including as a disinfectant and deodorizer. Food processing plants apply it to sanitize surfaces and equipment. Hospitals use it to sterilize medical devices, and some municipalities use low levels to treat public water supplies. Paper mills rely on it to whiten wood pulp. Safety experts advise those who handle it to work in well-ventilated spaces and to wear protective gloves.

Concentrations in drinking water systems higher than 0.8 milligrams per liter can be harmful, especially to infants, young children, and fetuses, according to the Environmental Protection Agency.

Still, for many years people in online discussion groups have been promoting the use of chlorine dioxide in a mixture that they call a “miracle mineral solution,” ingested to rid people of a host of maladies. The Food and Drug Administration has warned that drinking these chlorine dioxide mixtures can cause injury and even death.

It is not medicinal, despite Kory’s contention. “It is all lunacy. Absolutely, it’s 100% nonsense,” said Joe Schwarcz, director of McGill University’s Office for Science and Society in Montreal and an expert on the threat of pseudoscience. Schwarcz has written articles about the so-called miracle mineral solution, calling it “a poison” when it’s in high concentrations.

Kory’s book, set to be released to the public in January, argues that word of chlorine dioxide’s effectiveness has been suppressed by government and medical forces that need people to remain perpetually ill to generate large profits. The use of the word “war” in the title is fitting, Kory said in a recent online video on his co-author’s Substack. “In the book I detail many, many assassination attempts of doctors who try to bring out knowledge around chlorine dioxide,” he said.

Johnson confirmed to ProPublica in an email that he authorized the statement on the cover. “After reading the entire book, yes I provided and approved that blurb,” he said. “Have you read the book?”

ProPublica asked Kory and his co-author, Jenna McCarthy, to provide an advance copy, an interview, and responses to written questions. Kory did not respond. McCarthy wrote in an email to ProPublica that she was addressing some of the questions on her Substack. (She did not send a book or agree to an interview.)

The book “is a comprehensive examination of the existing evidence and a plea for open-minded inquiry and rigorous research,” she wrote on Substack. She dismissed warnings about chlorine dioxide’s toxicity in high concentrations, writing: “Everything has a toxic dose — including nutmeg, spinach, and tap water.”

She said that chlorine dioxide is being studied in controlled settings by researchers in the United States and Latin America and that “the real debate is how it should be used, at what dose, and in which clinical contexts.”

Her Substack post was signed “Jenna (& Pierre).”

Johnson did not agree to an interview and did not answer questions emailed to his office by ProPublica, including whether he views chlorine dioxide as a world-changing medical treatment and whether he believes the FDA warnings are false.

“It’s called snake oil”

Johnson has been an advocate of Kory’s for years, calling the doctor as an expert witness in two 2020 Senate hearings. In one, Kory championed taking the drug ivermectin, an antiparasite medicine, to treat COVID-19.

In 2021, an analysis of data from clinical trials concluded that ivermectin could reduce deaths from COVID-19 and may produce other positive effects. McCarthy cited that analysis in her Substack response.

In 2022, however, the American Journal of Therapeutics, which had published the study, warned that suspicious data “appears to invalidate the findings” regarding ivermectin’s potential to decrease deaths.

Later clinical trials have found no beneficial effect of ivermectin for COVID-19, and the FDA has warned that taking large doses can be dangerous. The drug’s manufacturer has said it hadn’t found any scientific basis for the idea that ivermectin can effectively treat COVID-19. Kory, though, continued advocating for ivermectin.

In 2024 the American Board of Internal Medicine, which credentials physicians in certain specialties, revoked Kory’s certifications in internal medicine, pulmonary disease, and critical care for making false and misleading public statements about the ability of ivermectin to treat COVID-19. Hospitals and many insurance networks typically require doctors to be board certified.

Kory vigorously fought the disciplinary action, arguing to the ABIM that he provided substantial medical and scientific evidence to support his recommendations for addressing COVID-19, though not the “consensus-driven” approach. He also sued the board in federal court, citing his free speech rights in a case that is still progressing in the 5th US Circuit Court of Appeals. On Substack, McCarthy excoriated the ABIM, saying it “bullies physicians” and “enforces ideological conformity.”

In 2022, Johnson and Kory penned a Fox News op-ed opposing a California bill that would strip doctors’ licenses for espousing misinformation about COVID-19. The bill became law but was repealed after a court fight. A federal judge found the statute’s definition of misinformation to be too vague, which could infringe on doctors’ right to free speech.

Johnson, who has been in Congress since 2011, has a history of advocating for experimental treatments and viewing the government as an impediment. Dr. Peter Lurie, president and executive director of the Center for Science in the Public Interest, a public health advocacy group, said that among members of Congress, Johnson was “an early adopter of anti-science ideas.”

Lurie said that Johnson is no longer an outlier in Washington, which now has many more elected lawmakers whom he considers anti-science. “What may have started off as the cutting edge of an anti-science movement has now turned into a much more broader-based movement that is supported by millions of people,” he said.

Earlier this year, Johnson held a hearing highlighting a flawed study claiming that vaccinated children had an increased rate of serious chronic diseases when compared to children who were not vaccinated. The conclusion questions the scientific consensus that vaccines are safe. The study’s researchers chose not to publish it because of problems they found in their data and methodology.

In November, Johnson and Kory were listed among the speakers at a conference of the Children’s Health Defense, a nonprofit that stirs anti-vaccine sentiment. It was launched in 2018 by Health and Human Services Secretary Robert F. Kennedy Jr., whose FDA is considering new ways to more closely scrutinize vaccine safety.

HHS did not respond to requests from ProPublica about Kennedy’s views on chlorine dioxide. At his confirmation hearing, Kennedy praised President Donald Trump for his wide search for a COVID-19 remedy in his first term, which Kennedy said included vaccines, various drugs, “even chlorine dioxide.”

Kory’s publisher is listed as Bella Luna Press, which has issued at least two other titles by McCarthy. “Thanks to the Censorship Industrial Complex, you won’t find The War on Chlorine Dioxide on Amazon or at Barnes & Noble. We had to design and build this website, figure out formatting and printing and shipping, and manage every aspect of order processing ourselves,” the book’s website states. (A representative for Bella Luna could not be reached for comment.)

As this new book is released, the autism community is also grappling with another controversy: the unsubstantiated assertion by Kennedy that Tylenol use by pregnant women poses an increased risk of autism. In addition, under Kennedy, the Centers for Disease Control and Prevention revised its website in November to cast doubt on the long-held scientific conclusion that childhood vaccines do not cause autism.

Some parents of children with autism, desperate for a remedy, have long reached for dubious and at times dangerous panaceas, including hyperbaric oxygen chambers and chelation therapy, used for the treatment of heavy metal poisoning. Neither method has been proven effective.

Helen Tager-Flusberg, director of the Center for Autism Research Excellence at Boston University, said Johnson has “acted extremely irresponsibly” in lending his name to a book making claims about chlorine dioxide treating autism.

“Wisconsin is filled with experts—clinical experts, medical experts, scientists—who understand and have studied autism and treatments for autism for many many years,” she said. “He’s chosen to completely ignore the clinical and the scientific community.”

People with autism may take medication to reduce anxiety, address attention problems, or reduce severe irritability. Many benefit from behavioral interventions and special education services to help with learning and functional abilities. But there is no cure, said Tager-Flusberg.

Referring to chlorine dioxide, she said: “We have had examples of this probably throughout the history of medicine. There’s a word for this, it’s called snake oil.”

In her response on Substack to ProPublica, McCarthy wrote that “chlorine dioxide is being used to treat (nobody said ‘cure’) autism with life-changing results.”

The search for miracle cures

The mother of an autistic son, Melissa Eaton of North Carolina, heard Kory reference his book in early November on The HighWire, an Internet talk show hosted by Del Bigtree, a prominent vaccine skeptic and former communications director for Kennedy’s 2024 presidential campaign. She then looked up the book online and noticed Johnson’s endorsement.

Eaton for many years has worked to expose people who peddle chlorine dioxide and to report apparent injuries to authorities. She monitors social media forums where parents discuss giving it to their children orally or via enemas. Sometimes the families reveal that their children are sick. “They’re throwing up and vomiting and having diarrhea and rashes,” Eaton said.

Some adherents advise parents that the disturbing effects indicate that the treatment is working, ridding the body of impurities, or that the parents should alter the dosage.

“Most of these kids are nonverbal,” Eaton said. “They’re not able to say what’s hurting them or what’s happening to them. The parents feel they’re doing the right thing. That’s how they view this: They’re helping to cure autism.”

The idea that chlorine dioxide can be a miracle cure began to spread about 20 years ago when a gold prospector, Jim Humble, wrote a book claiming his team in Guyana fell ill with malaria and recovered after drinking safe amounts of chlorine dioxide.

Humble later co-founded a “health and healing” church in Florida with a man named Mark Grenon, who called himself an archbishop and sold a chlorine dioxide solution as a cure for COVID-19. They described it as a “miracle mineral solution,” or MMS.

Grenon went to prison in 2023 for conspiring to defraud the United States by distributing an unapproved and misbranded drug. The scheme took in more than $1 million, according to prosecutors.

An affidavit in the case filed by a special agent with the FDA Office of Criminal Investigations noted: “FDA has received numerous reports of adverse reactions to MMS. These adverse reactions include hospitalizations, life-threatening conditions, and death.”

Grenon, who is now out of prison, told ProPublica that he too is writing a book about chlorine dioxide. “My book will tell the truth.” He declined further comment.

Chlorine dioxide is currently used in many ways that are not harmful. It is found in some consumer products like mouthwashes, but it is not meant to be swallowed in those instances. (One popular mouthwash warns to “keep out of reach of children.”) It’s also available to consumers in do-it-yourself packages where they combine drops from two bottles of different compounds—commonly sodium chlorite and hydrochloric acid—and add it to water. Hikers often carry the drops, or tablets, using small amounts to make quarts of fresh water potable.

But numerous online shoppers post product reviews that go further, referring to it as a tonic. Various online guides, some aimed at parents of autistic children, recommend a shot-glass-size dose, sometimes given multiple times a day and even hourly. That can far exceed the threshold the EPA considers safe.

McCarthy, addressing ProPublica on Substack, wrote: “You point to various online guides that offer what could be considered dangerous dosing instructions. We agree, the internet is a terrifying wasteland of misinformation and disinformation.”

In the Substack video, Kory said he felt compelled to spread the word about chlorine dioxide much as he did about ivermectin, even though it cost him professionally.

He no longer has a valid medical license in Wisconsin or California, where he did not renew them, according to the Substack post. His medical licenses in New York and Michigan are active.

“I like to say I was excommunicated from the church of the medical establishment,” he said in the Substack video. As a result, he said, he turned to telehealth and started a practice.

In the November 6 HighWire episode hosted by Bigtree, the discussion included talk not just of chlorine dioxide’s medicinal potential but also of how cheap and easy it is to obtain.

“On Amazon, it’s literally, you get two bottles, well, it comes in two,” Kory started to explain, before stopping that train of thought.

“I wouldn’t know how to make it,” he said.

This story was originally published by ProPublica. ProPublica is a Pulitzer Prize-winning investigative newsroom. Sign up for The Big Story newsletter to receive stories like this one in your inbox.

Senator endorses discredited doctor’s book that claims chemical treats autism, cancer Read More »

Ars Live: 3 former CDC leaders detail impacts of RFK Jr.’s anti-science agenda

Ars Live Chat, CDC, health, Science / Tim Belzer / December 11, 2025

The Centers for Disease Control and Prevention is in critical condition. This year, the premier public health agency had its funding brutally cut and staff gutted, its mission sabotaged, and its headquarters riddled with literal bullets. The over 500 rounds fired were meant for its scientists and public health experts, who endured only to be sidelined, ignored, and overruled by Health Secretary Robert F. Kennedy Jr., an anti-vaccine activist hellbent on warping the agency to fit his anti-science agenda.

Then, on August 27, Kennedy fired CDC Director Susan Monarez just weeks after she was confirmed by the Senate. She had refused to blindly approve vaccine recommendations from a panel of vaccine skeptics and contrarians that he had hand-selected. The agency descended into chaos, and Monarez wasn’t the only one to leave the agency that day.

Three top leaders had reached their breaking point and coordinated their resignations upon the dramatic ouster: Drs. Demetre Daskalakis, Debra Houry, and Daniel Jernigan walked out of the agency as their colleagues rallied around them.

Dr. Daskalakis was the director of the CDC National Center for Immunization and Respiratory Diseases. He managed national responses to mpox, measles, seasonal flu, bird flu, COVID-19, and RSV.

Ars Live: 3 former CDC leaders detail impacts of RFK Jr.’s anti-science agenda Read More »

Sperm donor with rare cancer mutation fathered nearly 200 children in Europe

health / Paul Patrick / December 10, 2025

A single sperm donor who carries a rare cancer-causing genetic mutation has fathered at least 197 children across 14 countries in Europe, according to a collaborative investigation by 14 European news groups.

According to their investigative report, some of the children have already died, and many others are expected to develop deadly cancers.

The man—Donor 7069, alias “Kjeld”—carries a rare mutation in the TP53 gene, which codes for a critical tumor suppressor called protein 53 or p53. This protein (which is a transcription factor) keeps cells from dividing uncontrollably, can activate DNA repair processes amid damage, and can trigger cell death when a cell is beyond repair. Many cancers are linked to mutations in p53.

When a p53 mutation is passed down in sperm (a germline mutation), it causes a rare autosomal dominant condition called Li Fraumeni syndrome, which greatly increases the risk of a variety of cancers in childhood and young adults. Those include cancers of the brain, blood, bone, soft tissue, adrenal glands, and breast, among others.

The estimated frequency of this type of mutation is between 1 in 5,000 and 1 in 20,000 .

According to the investigation, the man was unaffected by the condition, but the mutation was present in around 20 percent of his sperm.

Sperm donor with rare cancer mutation fathered nearly 200 children in Europe Read More »

Over 250 people quarantined in South Carolina as measles outbreak rages

health, Infectious disease, measles, misinformation, outbreak, South Carolina, virus / Kris Guyer / December 9, 2025

The quarantine period for measles is 21 days from the exposure, which is the maximum incubation period before the tell-tale rash appears. Measles is highly infectious, with up to 90 percent of unvaccinated or otherwise vulnerable people contracting the virus upon exposure. People infected with measles are infectious from four days before the rash appears to four days after its onset.

The outbreak is occurring in the northern region of South Carolina, with many cases identified in Spartanburg County, which contains Inman, as well as Greenville County. Both counties have low vaccination rates. For the 2024–2025 school year, only 90 percent of Spartanburg students were vaccinated, while Greenville’s vaccination rate was 92.4 percent. Those numbers are well below the 95 percent target needed to halt community transmission.

The two counties’ low vaccination rates are coupled with high rates of religious exemptions. Spartanburg has the state’s highest rate, with 8.2 percent of students exempt from the school vaccination requirement based on religious beliefs. Neighboring Greenville has a religious vaccination exemption rate of 5.3 percent.

Of the 111 outbreak cases, 105 were unvaccinated, three were partially vaccinated, two had an unknown status, and one case was fully vaccinated.

On a national scale, vaccination rates have declined overall amid misinformation spread by anti-vaccine activists, including current Health Secretary Robert F. Kennedy Jr. As such, measles cases are at a 33-year high, with nearly 2,000 cases this year and 46 outbreaks.

Over 250 people quarantined in South Carolina as measles outbreak rages Read More »

Without evidence, RFK Jr.’s vaccine panel tosses hep B vaccine recommendation

ACIP, anti-vaccine, CDC, health, hepatitis B, robert f kennedy jr / Rejus Almole / December 5, 2025

Retsef Levi, an operations management expert and ACIP member who expressed strong anti-vaccine views, said, “I think that the intention behind this [recommendation change is] that parents should carefully think about whether they want to take the risk of giving another vaccine to their child, and many of them might decide that they want to wait far more than two months, maybe years and maybe up to adulthood.”

In the discussion before the vote, Meissner described the motivation as “baseless skepticism.”

With a second vote, the panel created a new recommendation that parents and health care providers should consider testing a child’s antibody levels after each dose of the three-dose hepatitis B series. The recommendation suggests that if a baby’s antibody levels reach a certain threshold, they can forgo completing the series.

CDC subject matter experts, medical organizations, and members of the committee pointed out that there is no data to support this recommendation. Vaccine efficacy data is based on the entire three-dose series, and antibody levels are not sufficient to presume the same level of lifelong protection.

This vote “is kind of making things up,” Meissner said in frustration. “I mean, it’s like Never Never Land.”

There was no data or discussion on the administrative burden or clinical feasibility of testing the antibody levels of a baby after each dose.

The panel approved the recommendation on antibody testing in a vote of 6–4, with one abstention.

Medical experts were quick to condemn today’s votes. Sandra Adamson Fryhofer, a board member of the American Medical Association, said the vote is “reckless and undermines decades of public confidence in a proven, lifesaving vaccine.”

“Today’s action is not based on scientific evidence, disregards data supporting the effectiveness of the Hepatitis B vaccine, and creates confusion for parents about how best to protect their newborns,” Fryhofer said in a statement.

Without evidence, RFK Jr.’s vaccine panel tosses hep B vaccine recommendation Read More »

CDC vaccine panel realizes again it has no idea what it’s doing, delays big vote

anti-vaccine, CDC, health, robert f kennedy jr / Paul Patrick / December 4, 2025

Today’s meeting was chaotic and included garbage anti-vaccine presentations.

Dr. Robert Malone speaks during a meeting of the CDC Advisory Committee on Immunization Practices (ACIP) at CDC Headquarters on December 4, 2025 in Atlanta, Georgia. Credit: Getty | Elijah Nouvelage

The panel of federal vaccine advisors hand-selected by anti-vaccine Health Secretary Robert F. Kennedy Jr. has once again punted on whether to strip recommendations for hepatitis B vaccinations for newborns—a move it tried to make in September before realizing it didn’t know what it was doing. The decision to delay the vote today came abruptly this afternoon when the panel realized it still does not understand the topic or what it was voting on.

Prior to today’s 6–3 vote to delay a decision, there was a swirl of confusion over the wording of what a new recommendation would be. Panel members had gotten three different versions of the proposed recommendation in the 72 hours prior to the meeting, one panelist said. And the meeting’s data presentations this morning offered no clarity on the subject—they were delivered entirely by anti-vaccine activists who have no subject matter expertise and who made a dizzying amount of false and absurd claims.

“Completely inappropriate”

Overall, the meeting was disorganized and farcical. Kennedy’s panel has abandoned the evidence-based framework for setting vaccine policy in favor of airing unvetted presentations with misrepresentations, conspiracy theories, and cherry-picked studies. At times, there were tense exchanges, chaos, confusion, and misunderstandings.

Still, the discussion was watched closely by the medical and health community, which expects that the panel—composed of Kennedy allies who espouse anti-vaccine views—will strip the recommendation for a hepatitis B vaccine birth dose. Decisions by the committee, the Advisory Committee on Immunization Practices (ACIP) in the Centers for Disease Control and Prevention, have historically set national vaccine policy. Health insurance programs are required to cover, at no cost, vaccinations recommended by the ACIP. So rescinding a recommendation means Americans could lose coverage.

Medical and public health experts consider the birth-dose vaccination to be critical for protecting all infants from contracting the highly infectious virus that, when acquired early in life from their mother or anyone else, almost always causes chronic infections that lead to liver disease, cancer, and early death. There is no data suggesting harms from the newborn dose, nor any safety data suggesting that delaying the first dose by a month or two, as ACIP is considering, would be safer or better in any way. But studies do indicate that such a delay would lead to more hepatitis B infections in babies

These points were hard to find in today’s presentations. Abandoning standard protocol, the meeting did not include any presentations or data reviews led by CDC scientists or subject matter experts. Kennedy has also barred medical and health expert liaisons—such as the American Medical Association, the Infectious Disease Society of America, and the American Academy of Pediatrics—from participating in the ACIP working groups, which compile data and set language for proposed vaccine recommendations.

Anti-vaccine presentations

Instead, today, ACIP heard only from anti-vaccine activists. The first was Cynthia Nevison, a climate researcher and anti-vaccine activist with ties to Children’s Health Defense, Kennedy’s anti-vaccine organization. She was also a board member of an advocacy group called Safe Minds, which promotes a false link between autism and vaccines, specifically the mercury-containing vaccine preservative thimerosal, which was removed from routine childhood vaccines in the early 2000s. (Safe Minds stands for Sensible Action For Ending Mercury-Induced Neurological Disorders.) According to her academic research profile at the University of Colorado Boulder, her expertise is in “global biogeochemical cycles of carbon and nitrogen and their impact on atmospheric trace gases.”

Far from that topic, Nevison gave a presentation downplaying the transmission of hepatitis B and the benefits of vaccines. She falsely claimed that the dramatic decline in hepatitis B infections that followed vaccination efforts was not actually due to the vaccination efforts—despite irrefutable evidence that it was. And she followed that up with her own unvetted modeling claiming that CDC scientists overestimate the risk of transmission. She ended by presenting a few studies showing declines in blood antibody levels after initial vaccination, which she claimed suggests that the hepatitis B vaccine does not offer lifelong protection, an incorrect takeaway based on her lack of expertise.

The author of one of the studies just happened to be present at today’s meeting. Pediatrician Amy Middleman, who is an ACIP liaison representing the Society for Adolescent Health and Medicine (SAHM) and a professor at Case Western Reserve University School of Medicine, was the first author on a key study Nevison referenced. Middleman was quick to point out that Nevison had completely misunderstood the study, which actually showed that cell-based immune protection from the vaccine offers robust lifelong protection, even after initial antibody levels decline (called an anamnestic response).

“This is where a really experienced understanding of immunization comes into play,” Middleman said. “The entire point of our study is that for most vaccines, the anamnestic response is really their superpower. So this study showed that memory cells exist such that when they see something that looks like the hepatitis B disease, they actually attack. The presence of a robust and anamnestic response, regardless of circulating antibody years later, shows true protection.”

The next presentation was from Mark Blaxill, an anti-vaccine activist installed at the CDC in September. Blaxill gave a presentation on hepatitis B vaccine safety, despite having no background in medicine or science. He previously worked as an executive for a technology investment firm and, like Nevison, also worked for Safe Minds, where he was vice president. Blaxill has written books and many articles falsely claiming that vaccines cause a variety of harms in children. In 2004, when an Institute of Medicine analysis concluded that there were no convincing links between vaccines and autism, Blaxill publicly protested the result.

In his presentation, he attacked the quality of safety data in past hepatitis B studies. Though he stopped short of suggesting any specific harms from the vaccine, he aired unsubstantiated possibilities popular with anti-vaccine activists. He also noted a study finding that some babies had fatigue and irritability after vaccination, which he bizarrely suggested was a sign of encephalitis (inflammation of the brain).

Real-time feedback

Cody Meissner, a pediatrician and voting member of ACIP who is the most qualified and experienced member of the panel, quickly called out the suggestion as ridiculous. “That is absolutely not encephalitis,” Meissner said with frustration in his voice. “That’s not a statement that a physician would make. [Those symptoms] are not related to encephalitis, and you can’t say that.”

As in previous meetings, Jason Goldman, the ACIP liaison representing the American College of Physicians, gave the most biting response to the meeting overall, saying:

Once again, this committee fails to use the evidence to recommend framework and shows absolutely no understanding of the process or the gravity of the moment of the recommendations that you make. We need to look at all the evidence and data and not cherry-pick them… This meeting is completely inappropriate for an administration that wants to avoid fraud, waste, and abuse. You are wasting taxpayer dollars by not having scientific, rigorous discussion on issues that truly matter. The best thing you can do is adjourn the meeting and discuss vaccine issues that actually need to be taken up… As physicians, your ethical obligation is primum non nocere, first do no harm, and you are failing in that by promoting this anti-vaccine agenda without the data and evidence necessary to make those informed decisions.

The panel will reconvene tomorrow for an all-day meeting in which the members will consider a vote on the hepatitis B vaccine for a third time. The meeting will also host other anti-vaccine presentations attacking the childhood vaccine schedule in its entirety.

Beth is Ars Technica’s Senior Health Reporter. Beth has a Ph.D. in microbiology from the University of North Carolina at Chapel Hill and attended the Science Communication program at the University of California, Santa Cruz. She specializes in covering infectious diseases, public health, and microbes.

CDC vaccine panel realizes again it has no idea what it’s doing, delays big vote Read More »

More FDA drama: Top drug regulator calls it quits after 3 weeks

fda, health / Mike M. / December 2, 2025

The top drug regulator at the Food and Drug Administration, Richard Pazdur, has decided to retire from the agency just three weeks after taking the leading position, according to multiple media outlets.

Pazdur, an oncologist who has worked at the FDA since 1999, was seen as a stabilizing force for an agency that has been mired in turmoil during the second Trump administration. He took over the role of leading the FDA’s Center for Drug Evaluation and Research on November 11, after the previous leader, George Tidmarsh, left the agency amid an investigation and a lawsuit regarding allegations that he used his position to exact petty revenge on a former business partner. In light of the scandal, one venture capital investor called the agency a “clown show.” Drug industry groups, meanwhile, called the FDA erratic and unpredictable.

Pazdur’s selection was seen as a positive sign by agency insiders, drug industry representatives, and patient advocacy groups, according to reporting by The Washington Post.

But things quickly soured. Just days on the job, Pazdur expressed deep concerns about the legality and public health risks of FDA Commissioner Marty Makary’s plans to overhaul and expedite agency operations. On November 21, the Post reported that Pazdur disagreed with Makary’s plans to reduce the number of studies needed to make drug-related decisions, such as label changes. Pazdur was further concerned that Makary’s plan to shorten drug review times was not sufficiently transparent and could be illegal. Pazdur also pushed back on Makary’s plan to exclude agency career scientists from some drug review processes deemed political priorities.

More FDA drama: Top drug regulator calls it quits after 3 weeks Read More »

Meet CDC’s new lead vaccine advisor who thinks shots cause heart disease

ACIP, anti-vaccine, CDC, fda, health, Kirk Milhoan, myocarditis, robert f kennedy jr, vinay prasad / Paul Patrick / December 2, 2025

Milhoan has a history of touting unproven COVID cures while disparaging vaccines.

Kirk Milhoan, James Pagano, and Robert Malone are seen during a meeting of the CDC’s Advisory Committee on Immunization Practices on September 18, 2025 in Chamblee, Georgia. Credit: Getty | Elijah Nouvelage

When the federal vaccine committee hand-picked by anti-vaccine Health Secretary Robert F. Kennedy Jr. meets again this week, it will have yet another new chairperson to lead its ongoing work of dismantling the evidence-based vaccine recommendations set by the Centers for Disease Control and Prevention.

On Monday, the Department of Health and Human Services announced that the chairperson who has been in place since June—when Kennedy fired all 17 expert advisors on the committee and replaced them with questionably qualified allies—is moving to a senior role in the department. Biostatistician Martin Kulldorff will now be the chief science officer for the Office of the Assistant Secretary for Planning and Evaluation (ASPE), HHS said. As such, he’s stepping down from the vaccine committee, the Advisory Committee on Immunization Practices (ACIP).

Kulldorff gained prominence amid the COVID-19 pandemic, criticizing public health responses to the crisis, particularly lockdowns and COVID-19 vaccines. He was a co-author of the Great Barrington Declaration that advocated for letting the deadly virus spread unchecked through the population, which was called unethical by health experts.

As ACIP chair, Kulldorff frequently made false and misleading statements about vaccine safety and efficacy that were in line with Kennedy’s views and statements. While Kulldorff presided over the committee, it made a series of decisions that were sharply denounced by scientific and medical groups as being based on ideology rather than evidence. Those include voting for the removal of the vaccine preservative thimerosal from some flu vaccines, despite well-established data indicating it is safe, with no evidence of harms. The committee also added restrictions to a combination measles, mumps, rubella, and varicella (chickenpox) MMRV vaccine and made an unprecedented effort to prevent Americans from getting COVID-19 vaccines, though the moves were largely ineffective.

In his new role, Kulldorff will be working with ASPE to provide analyses on health policy options, coordinate research efforts, and provide policy advice.

“It’s an honor to join the team of distinguished scientists that Secretary Kennedy has assembled,” Kulldorff said in a press release announcing his new role. “I look forward to contributing to the science-based public health policies that will Make America Healthy Again.”

The new chair, Kirk Milhoan

With Kulldorff moving on, ACIP will now be chaired by Kirk Milhoan, a pediatric oncologist with a track record for spreading COVID-19 misinformation and anti-vaccine views. In August 2021, the Hawaii Medical Board filed a complaint against Milhoan after he appeared on a panel promoting ineffective COVID-19 treatments, downplaying the severity of the disease, and spreading misinformation about COVID-19 vaccines, according to the Maui News. The complaint was dropped in April 2022 after state regulators said they had insufficient evidence to prove a violation of statutes regarding the practice of medicine.

While Milhoan claimed at the time that he is “pro-vaccine,” his statement, affiliations, and prescribing practices suggest otherwise. Milhoan is a member of the Independent Medical Alliance (formerly the Front Line COVID-19 Critical Care Alliance), a group of dubious health care providers set up amid the pandemic to promote the use of the anti-malaria drug hydroxychloroquine and the de-worming drug ivermectin to treat COVID-19. Both drugs have shown to be ineffective and potentially harmful when used to treat or prevent COVID-19. The IMA also emphasizes vaccine injuries while pushing vitamins and other unproven treatments.

In 2024, Milhoan appeared on a panel set up by Rep. Marjorie Taylor Greene (R-Ga.) to discuss alleged injuries from COVID-19 vaccines alongside other prominent anti-vaccine and COVID-19 misinformation voices. In his opening statement, Milhoan suggested that COVID-19 vaccines were causing severe cardiovascular disease and death in people aged 15 to 44—an unsubstantiated claim he frequently echoes. In his bio for the IMA, he touts that he offers treatment for “vaccine-related cardiovascular toxicity due to the spike protein.”

CDC data has found that boys and young men, aged 12 to 24, have a heightened risk of myocarditis (inflammation of the heart) after COVID-19 vaccination. However, the cases are rare, relatively mild, and almost always resolve, according to CDC data. In a COVID-19 safety data presentation in June, CDC staff scientists reported that its vast vaccine safety monitoring systems indicated that in males 12–24, there are 27 myocarditis cases per million doses of COVID-19 vaccine administered (roughly one case in 37,000 doses). In cases identified during 2021, 83 percent recovered within three months, with more than 90 percent recovering within the year. The monitoring data found no instances of cardiac transplant or death from COVID-19 vaccination.

While anti-vaccine activists have seized on this minor risk from vaccination, health experts note that the risk of myocarditis and other inflammatory conditions from a COVID-19 infection is significantly greater than the risk from vaccination. Exact estimates vary, but one CDC study in 2021 found that people with COVID-19 infections had a 16-fold higher risk of myocarditis than people without the infection. Specifically, the study estimated that there were 150 myocarditis cases among 100,000 COVID-19-infected patients versus just nine myocarditis cases among 100,000 people without COVID-19 infections and who were also unvaccinated. Similar to what’s seen with vaccination, the study found that young males were most at risk of myocarditis.

Kennedy’s allies attack on COVID-19 shots

Kennedy and his allies, like Milhoan, have consistently inflated the risk of myocarditis from COVID-19 vaccination, with some claiming without evidence that they have caused sudden cardiac arrest and deaths in young males, though studies have found no such link. In 2022, Milhoan and fellow ACIP member and conspiracy theorist Robert Malone were featured in a viral social media post suggesting that 50 percent of college athletes in the Big Ten athletic conference had myocarditis linked to COVID-19 vaccines, which could lead to deaths if they played. But the two were referencing a JAMA Cardiology study that examined subclinical myocarditis in Big Ten athletes after COVID-19 infection—not vaccination. In fact, researchers confirmed for an AFP fact check that none of the athletes in the study were vaccinated. And the rate of subclinical myocarditis in the group was 2.3 percent, not 50 percent.

Milhoan’s misinformation about the cardiovascular harms from COVID-19 vaccines seems particularly pertinent to the direction of Kennedy’s anti-vaccine allies. On Friday, Vinay Prasad, the Food and Drug Administration’s top vaccine regulator, sent a memo to staff claiming without evidence that COVID-19 vaccines have killed 10 children. The memo provides little information about the extraordinary claim, but it hints that the deaths were linked to myocarditis and found among reports submitted between 2021 and 2024 to the CDC’s Vaccine Adverse Event Reporting System (VAERS).

VAERS is a system by which anyone, including members of the public, can report anything they think could be linked to vaccines. The reports are considered a type of early warning system, but the vast majority of the reports submitted are not actually related to vaccines. Further, CDC scientists have thoroughly evaluated VAERS reports and ruled out deaths attributed to COVID-19 vaccines. Prasad’s memo—which experts have speculated was designed to be leaked to produce alarming headlines about child deaths—claimed that before Trump administration officials with anti-vaccine views began sifting through the data, these deaths were “ignored” by FDA and CDC scientists. Prasad also claimed that there could be many more deaths that have gone unreported, despite the fact that healthcare providers have been legally required to report any deaths that occurred after COVID-19 vaccination, regardless of cause.

This week’s ACIP meeting

In this week’s scheduled ACIP meeting on Thursday and Friday, COVID-19 vaccines don’t appear on the draft agenda. Instead, ACIP is expected to vote to remove a recommendation for a birth dose of the hepatitis B vaccine. That dose protects newborns from contracting the highly infectious virus from their mothers during birth or from other family or acquaintances shortly after birth. About half of the people infected with hepatitis B are not aware of their infections, and testing of mothers before birth is imperfect. That can leave newborns particularly vulnerable, as infections that start at or shortly after birth almost always develop into chronic infections that can lead to liver disease, liver transplant, and cancer. In a previous ACIP meeting, CDC staff scientists presented data showing that there are no significant harms of birth doses and there is no evidence that delaying the immunization offers any benefit.

The committee is also taking on the childhood vaccine schedule as a whole, though the agenda on this topic is not yet clear. In his memo, Prasad attacked the common practice of providing multiple vaccinations at once, hinting that it could be a way in which the committee will try to dismantle current childhood vaccination recommendations. On Tuesday, The Washington Post reported that the committee will examine whether the childhood vaccine schedule as a whole is causing allergies and autoimmune diseases, something Kennedy and his anti-vaccine organization have long floated despite evidence refuting a link.

Under clear attack are aluminum salt adjuvants, which are used in many vaccines to help spur protective immune responses. Aluminum salts have been used safely in vaccines for more than 70 years. The FDA notes that the most common source of aluminum exposure is from food and water, not vaccines.

Meet CDC’s new lead vaccine advisor who thinks shots cause heart disease Read More »

Achieving lasting remission for HIV

health, HIV, remission, Science, syndication / Kris Guyer / November 29, 2025

Promising trials using engineered antibodies suggest that “functional cures” may be in reach.

A digital illustration of an HIV-infected T cell. Once infected, the immune cell is hijacked by the virus to produce and release many new viral particles before dying. As more T-cells are destroyed, the immune system is progressively weakened. Credit: Kateryna Kon/Science Photo Library via Getty Images

Around the world, some 40 million people are living with HIV. And though progress in treatment means the infection isn’t the death sentence it once was, researchers have never been able to bring about a cure. Instead, HIV-positive people must take a cocktail of antiretroviral drugs for the rest of their lives.

But in 2025, researchers reported a breakthrough that suggests that a “functional” cure for HIV—a way to keep HIV under control long-term without constant treatment—may indeed be possible. In two independent trials using infusions of engineered antibodies, some participants remained healthy without taking antiretrovirals, long after the interventions ended.

In one of the trials—the FRESH trial, led by virologist Thumbi Ndung’u of the University of KwaZulu-Natal and the Africa Health Research Institute in South Africa—four of 20 participants maintained undetectable levels of HIV for a median of 1.5 years without taking antiretrovirals. In the other, the RIO trial set in the United Kingdom and Denmark and led by Sarah Fidler, a clinical doctor and HIV research expert at Imperial College London, six of 34 HIV-positive participants have maintained viral control for at least two years.

These landmark proof-of-concept trials show that the immune system can be harnessed to fight HIV. Researchers are now looking to conduct larger, more representative trials to see whether antibodies can be optimized to work for more people.

“I do think that this kind of treatment has the opportunity to really shift the dial,” Fidler says, “because they are long-acting drugs”—with effects that can persist even after they’re no longer in the body. “So far, we haven’t seen anything that works like that.”

People with HIV can live long, healthy lives if they take antiretrovirals. But their lifespans are still generally shorter than those of people without the virus. And for many, daily pills or even the newer, bimonthly injections present significant financial, practical, and social challenges, including stigma. “Probably for the last about 15 or 20 years, there’s been this real push to go, ‘How can we do better?’” says Fidler.

The dream, she says, is “what people call curing HIV, or a remission in HIV.” But that has presented a huge challenge because HIV is a master of disguise. The virus evolves so quickly after infection that the body can’t produce new antibodies quickly enough to recognize and neutralize it.

And some HIV hides out in cells in an inactive state, invisible to the immune system. These evasion tactics have outwitted a long succession of cure attempts. Aside from a handful of exceptional stem-cell transplants, interventions have consistently fallen short of a complete cure—one that fully clears HIV from the body.

A functional cure would be the next best thing. And that’s where a rare phenomenon offers hope: Some individuals with long-term HIV do eventually produce antibodies that can neutralize the virus, though too late to fully shake it. These potent antibodies target critical, rarely changing parts of HIV proteins in the outer viral membrane; these proteins are used by the virus to infect cells. The antibodies, able to recognize a broad range of virus strains, are termed broadly neutralizing.

Scientists are now racing to find the most potent broadly neutralizing antibodies and engineer them into a functional cure. FRESH and RIO are arguably the most promising attempts yet.

In the FRESH trial, scientists chose two antibodies that, combined, were likely to be effective against HIV strains known as HIV-1 clade C, which is dominant in sub-Saharan Africa. The trial enrolled young women from a high-prevalence community as part of a broader social empowerment program. The program had started the women on HIV treatment within three days of their infection several years earlier.

The RIO trial, meanwhile, chose two well-studied antibodies shown to be broadly effective. Its participants were predominantly white men around age 40 who also had gone on antiretroviral drugs soon after infection. Most had HIV-1 clade B, which is more prevalent in Europe.

By pairing antibodies, the researchers aimed to decrease the likelihood that HIV would develop resistance—a common challenge in antibody treatments—since the virus would need multiple mutations to evade both.

Participants in both trials were given an injection of the antibodies, which were modified to last around six months in the body. Then their treatment with antiviral medications was paused. The hope was that the antibodies would work with the immune system to kill active HIV particles, keeping the virus in check. If the effect didn’t last, HIV levels would rise after the antibodies had been broken down, and the participants would resume antiretroviral treatment.

Excitingly, however, findings in both trials suggested that, in some people, the interventions prompted an ongoing, independent immune response, which researchers likened to the effect of a vaccine.

In the RIO trial, 22 of the 34 people receiving broadly neutralizing antibodies had not experienced a viral rebound by 20 weeks. At this point, they were given another antibody shot. Beyond 96 weeks—long after the antibodies had disappeared — six still had viral levels low enough to remain off antiviral medications.

An additional 34 participants included in the study as controls received only a saline infusion and mostly had to resume treatment in four to six weeks; all but three were back on treatment within 20 weeks.

A similar pattern was observed in FRESH (although, because it was mostly a safety study, this trial did not include control participants). Six of the 20 participants retained viral suppression for 48 weeks after the antibody infusion, and of those, four remained off treatment for more than a year. Two and a half years after the intervention, one remains off antiretroviral medication. Two others also maintained viral control but eventually chose to go back on treatment for personal and logistical reasons.

It’s unknown when the virus might rebound, so the researchers are cautious about calling participants in remission functionally cured. However, the antibodies clearly seem to coax the immune system to fight the virus. Attached to infected cells, they signal to immune cells to come in and kill.

And importantly, researchers believe that this immune response to the antibodies may also stimulate immune cells called CD8+ T cells, which then hunt down HIV-infected cells. This could create an “immune memory” that helps the body control HIV even after the antibodies are gone.

The response resembles the immune control seen in a tiny group (fewer than 1 percent) of individuals with HIV, known as elite controllers. These individuals suppress HIV without the help of antiretrovirals, confining it mostly to small reservoirs. That the trials helped some participants do something similar is exciting, says Joel Blankson, an infectious diseases expert at Johns Hopkins Medicine, who coauthored an article about natural HIV controllers in the 2024 Annual Review of Immunology. “It might teach us how to be able to do this much more effectively, and we might be able to get a higher percentage of people in remission.”

One thing scientists do know is that the likelihood of achieving sustained control is higher if people start antiretroviral treatment soon after infection, when their immune systems are still intact and their viral reservoirs are small.

But post-treatment control can occur even in people who started taking antiretrovirals a long time after they were initially infected: a group known as chronically infected patients. “It just happens less often,” Blankson says. “So it’s possible the strategies that are involved in these studies will also apply to patients who are chronically infected.”

A particularly promising finding of the RIO trial was that the antibodies also affected dormant HIV hiding out in some cells. These reservoirs are how the virus rebounds when people stop treatment, and antibodies aren’t thought to touch them. Researchers speculate that the T cells boosted by the antibodies can recognize and kill latently infected cells that display even trace amounts of HIV on their surface.

The FRESH intervention, meanwhile, targeted the stubborn HIV reservoirs more directly through incorporating another drug, called vesatolimod. It’s designed to stimulate immune cells to respond to the HIV threat, and hopefully to “shock” dormant HIV particles out of hiding. Once that happens, the immune system, with the help of the antibodies, can recognize and kill them.

The results of FRESH are exciting, Ndung’u says, “because it might indicate that this regimen worked, to an extent. Because this was a small study, it’s difficult to, obviously, make very hard conclusions.” His team is still investigating the data.

Once he secures funding, Ndung’u aims to run a larger South Africa-based trial including chronically infected individuals. Fidler’s team, meanwhile, is recruiting for a third arm of RIO to try to determine whether pausing antiretroviral treatment for longer before administering the antibodies prompts a stronger immune response.

A related UK-based trial, called AbVax, will add a T-cell-stimulating drug to the mix to see whether it enhances the long-lasting, vaccine-like effect of the antibodies. “It could be that combining different approaches enhances different bits of the immune system, and that’s the way forward,” says Fidler, who is a co-principal investigator on that study.

For now, Fidler and Ndung’u will continue to track the virally suppressed participants — who, for the first time since they received their HIV diagnoses, are living free from the demands of daily treatment.

This story originally appeared at Knowable Magazine.

Knowable Magazine explores the real-world significance of scholarly work through a journalistic lens.

Achieving lasting remission for HIV Read More »

Four-inch worm hatches in woman’s forehead, wriggles to her eyelid

CDC, eye, health, Infectious disease, New England Journal of Medicine, parasite, worm / Mike M. / November 27, 2025

Creeping

For anyone enjoying—or at least trying to enjoy—Thanksgiving in America, you can be thankful that these worms are not present in the US; they are exclusive to the “Old World,” that is Europe, Africa, and Asia, according to the Centers for Disease Control and Prevention. They’re often found in the Mediterranean region, but reports in recent years have noted that they seem to be expanding into new areas of Europe—particularly eastward and northward. In a report earlier this year of cases in Estonia, researchers noted that it is also emerging in Lithuania, Latvia, and Finland.

Researchers attribute the worm’s creep to climate change and globalization. But in another report this year of a case in Austria (thought to be acquired while the patient was vacationing in Greece), researchers also raised the speculation that the worms may be adapting to use humans as a true host. Researchers in Serbia suggested this in a 2023 case report, in which an infection led to microfilariae in the patient’s blood. The researchers speculated that such cases, considered rare, could be increasing.

For now, people in America have less to worry about. D. repens has not been found in the US, but it does have some relatives here that occasionally show up in humans, including D. immitis, the cause of dog heartworm, and D. tenuis. The latter can cause similar cases to D. repens, with worms wandering under the skin, particularly around the eye. So far, this worm has mainly been found in raccoons in Florida.

For those who do find a worm noodling through their skin, the outlook is generally good. Treatment includes surgical removal of the worm, which largely takes care of the problem, as well as anti-parasitic or antibiotic drugs to be sure to stamp out the infection or any co-infections. In the woman’s case, her symptoms disappeared after doctors pulled the worm from her eyelid.

Four-inch worm hatches in woman’s forehead, wriggles to her eyelid Read More »

RFK Jr.’s new CDC deputy director prefers “natural immunity” over vaccines

anti-vaccine, CDC, health, public health, ralph abraham, Robert F Kenned Jr., vaccine / Kris Guyer / November 26, 2025

Under ardent anti-vaccine Health Secretary Robert F. Kennedy Jr., the Centers for Disease Control and Prevention has named Louisiana Surgeon General Ralph Abraham as its new principal deputy director—a choice that was immediately called “dangerous” and “irresponsible,” yet not as bad as it could have been, by experts.

Physician Jeremy Faust revealed the appointment in his newsletter Inside Medicine yesterday, which was subsequently confirmed by journalists. Faust noted that a CDC source told him, “I heard way worse names floated,” and although Abraham’s views are “probably pretty terrible,” he at least has had relevant experience running a public health system, unlike other current leaders of the agency.

But Abraham hasn’t exactly been running a health system the way most public health experts would recommend. Under Abraham’s leadership, the Louisiana health department waited months to inform residents about a deadly whooping cough (pertussis) outbreak. He also has a clear record of anti-vaccine views. Earlier this year, he told a Louisiana news outlet he doesn’t recommend COVID-19 vaccines because “I prefer natural immunity.” In February, he ordered the health department to stop promoting mass vaccinations, including flu shots, and barred staff from running seasonal vaccine campaigns.

RFK Jr.’s new CDC deputy director prefers “natural immunity” over vaccines Read More »