Science

scientists-aghast-at-bizarre-ai-rat-with-huge-genitals-in-peer-reviewed-article

Scientists aghast at bizarre AI rat with huge genitals in peer-reviewed article

AI, frontiers, MidJourney, rats, Science, Scientific publishing / /

AI gone wild —

It’s unclear how such egregiously bad images made it through peer-review.

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An actual laboratory rat, who is intrigued.

Enlarge / An actual laboratory rat, who is intrigued.

Appall and scorn ripped through scientists’ social media networks Thursday as several egregiously bad AI-generated figures circulated from a peer-reviewed article recently published in a reputable journal. Those figures—which the authors acknowledge in the article’s text were made by Midjourney—are all uninterpretable. They contain gibberish text and, most strikingly, one includes an image of a rat with grotesquely large and bizarre genitals, as well as a text label of “dck.”

AI-generated Figure 1 of the paper. This image is supposed to show spermatogonial stem cells isolated, purified, and cultured from rat testes.

Enlarge / AI-generated Figure 1 of the paper. This image is supposed to show spermatogonial stem cells isolated, purified, and cultured from rat testes.

On Thursday, the publisher of the review article, Frontiers, posted an “expression of concern,” noting that it is aware of concerns regarding the published piece. “An investigation is currently being conducted and this notice will be updated accordingly after the investigation concludes,” the publisher wrote.

The article in question is titled “Cellular functions of spermatogonial stem cells in relation to JAK/STAT signaling pathway,” which was authored by three researchers in China, including the corresponding author Dingjun Hao of Xi’an Honghui Hospital. It was published online Tuesday in the journal Frontiers in Cell and Developmental Biology.

Frontiers did not immediately respond to Ars’ request for comment, but we will update this post with any response.

The first figure in the paper, the one containing the rat, drew immediate attention as scientists began widely sharing it and commenting on it on social media platforms, including Bluesky and the platform formerly known as Twitter. From a distance, the anatomical image is clearly all sorts of wrong. But, looking closer only reveals more flaws, including the labels “dissilced,” Stemm cells,” “iollotte sserotgomar,” and “dck.” Many researchers expressed surprise and dismay that such a blatantly bad AI-generated image could pass through the peer-review system and whatever internal processing is in place at the journal.

Figure 2 is supposed to be a diagram of the JAK-STAT signaling pathway.

Enlarge / Figure 2 is supposed to be a diagram of the JAK-STAT signaling pathway.

But the rat’s package is far from the only problem. Figure 2 is less graphic but equally mangled. While it’s intended to be a diagram of a complex signaling pathway, it instead is a jumbled mess. One scientific integrity expert questioned whether it provide an overly complicated explanation of “how to make a donut with colorful sprinkles.” Like the first image, the diagram is rife with nonsense text and baffling images. Figure 3 is no better, offering a collage of small circular images that are densely annotated with gibberish. The image is supposed to provide visual representations of how the signaling pathway from Figure 2 regulates the biological properties of spermatogonial stem cells.

Some scientists online questioned whether the text was also AI-generated. One user noted that AI detection software determined that it was likely to be AI-generated; however, as Ars has reported previously, such software is unreliable.

Figure 3 is supposed to show the regulation of biological properties of spermatogonial stem cells by JAK/STAT signaling pathway.

Enlarge / Figure 3 is supposed to show the regulation of biological properties of spermatogonial stem cells by JAK/STAT signaling pathway.

The images, while egregious examples, highlight a growing problem in scientific publishing. A scientist’s success relies heavily on their publication record, with a large volume of publications, frequent publishing, and articles appearing in top-tier journals, all of which earn scientists more prestige. The system incentivizes less-than-scrupulous researchers to push through low-quality articles, which, in the era of AI chatbots, could potentially be generated with the help of AI. Researchers worry that the growing use of AI will make published research less trustworthy. As such, research journals have recently set new authorship guidelines for AI-generated text to try to address the problem. But for now, as the Frontiers article shows, there are clearly some gaps.

Scientists aghast at bizarre AI rat with huge genitals in peer-reviewed article Read More »

after-a-decade-and-$1.2-billion,-nasa-reveals-its-booty-from-bennu:-121-grams

After a decade and $1.2 billion, NASA reveals its booty from Bennu: 121 grams

bennu, Science, Space / /

To Bennu and back —

A long way, and a lot of money, for half a cup.

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A view of eight sample trays containing the final material from asteroid Bennu.

Enlarge / A view of eight sample trays containing the final material from asteroid Bennu.

NASA/Erika Blumenfeld & Joseph Aebersold

After years of speculation, NASA finally revealed on Thursday the totality of the asteroid sample returned from Bennu to Earth last fall: 4.29 ounces (121.6 grams).

To put that number into perspective, the total mass is only slightly more than one-half cup of sugar or a box of 100 paper clips. It’s about the same mass as a small avocado, and you can’t even smear it on toast.

So, in some sense, it’s a pretty small sample. Especially when you consider the lengths to which NASA and its partners went to retrieve it. The space agency’s Goddard Space Flight Center worked with the University of Arizona and Lockheed Martin to build the OSIRIS-REx spacecraft for $800 million. It launched in September 2016 on an Atlas V rocket, which cost an additional $183.5 million. And as it has traipsed across the inner Solar System and back, NASA has spent an additional $200 million on mission operations.

A tin of tuna

Putting that all together, NASA has invested $1.2 billion and the better part of a decade to retrieve a volume of asteroid dust that could fit—comfortably—within a small can of tuna.

But, as the saying goes, good things come in small packages. And small though the sample may be, it is 20 times greater than the amount of asteroid material previously returned to Earth by a pair of Japanese sample return missions. A little will go a long way as scientists study the organics and other materials in this asteroid dust to divine clues to the origin of life and conditions that existed at the dawn of our Solar System. You don’t need handfuls of material to get a meaningful result from an electron microscope.

Moreover, the sample retrieval was double the minimum requirement for the mission, 60 grams. So, OSIRIS-REx can now definitively be labeled as an unqualified success.

Biding their time

The scientific community had to wait longer than expected to know how much material OSIRIS-REx brought back to Earth. As engineers and technicians at Johnson Space Center in Houston worked to open the sample container last October, they were stymied by two stubborn fasteners. Only after new tools were devised was the sample container finally opened to reveal the tiny treasure in January.

In the coming weeks, some Bennu material will be packaged and distributed for researchers to study. As part of the OSIRIS-REx mission, a cohort of more than 200 scientists around the world will explore the regolith’s properties, including researchers from many US institutions, the Japan Aerospace Exploration Agency, and the Canadian Space Agency.

NASA, however, intends to reserve about 70 percent of the material for future study.

After a decade and $1.2 billion, NASA reveals its booty from Bennu: 121 grams Read More »

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SpaceX launches military satellites tuned to track hypersonic missiles

Commercial space, falcon 9, hypersonic, L3Harris, launch, missile defense, missile defense agency, Northrop Grumman, Science, Space, space development agency, spacex / /

Trackers —

These satellites will participate in joint missile tracking exercises later this year.

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SpaceX launched a Falcon 9 rocket Wednesday with six missile-tracking satellites for the US military.

Enlarge / SpaceX launched a Falcon 9 rocket Wednesday with six missile-tracking satellites for the US military.

Two prototype satellites for the Missile Defense Agency and four missile tracking satellites for the US Space Force rode a SpaceX Falcon 9 rocket into orbit Wednesday from Florida’s Space Coast.

These satellites are part of a new generation of spacecraft designed to track hypersonic missiles launched by China or Russia and perhaps emerging missile threats from Iran or North Korea, which are developing their own hypersonic weapons.

Hypersonic missiles are smaller and more maneuverable than conventional ballistic missiles, which the US military’s legacy missile defense satellites can detect when they launch. Infrared sensors on the military’s older-generation missile tracking satellites are tuned to pick out bright thermal signatures from missile exhaust.

The new threat paradigm

Hypersonic missiles represent a new challenge for the Space Force and the Missile Defense Agency (MDA). For one thing, ballistic missiles follow a predictable parabolic trajectory that takes them into space. Hypersonic missiles are smaller and comparatively dim, and they spend more time flying in Earth’s atmosphere. Their maneuverability makes them difficult to track.

A nearly 5-year-old military organization called the Space Development Agency (SDA) has launched 27 prototype satellites over the last year to prove the Pentagon’s concept for a constellation of hundreds of small, relatively low-cost spacecraft in low-Earth orbit. This new fleet of satellites, which the SDA calls the Proliferated Warfighter Space Architecture (PWSA), will eventually number hundreds of spacecraft to track missiles and relay data about their flight paths down to the ground. The tracking data will provide an early warning to those targeted by hypersonic missiles and help generate a firing solution for interceptors to shoot them down.

The SDA constellation combines conventional tactical radio links, laser inter-satellite communications, and wide-view infrared sensors. The agency, now part of the Space Force, plans to launch successive generations, or tranches, of small satellites, each introducing new technology. The SDA’s approach relies on commercially available spacecraft and sensor technology and will be more resilient to attack from an adversary than the military’s conventional space assets. Those legacy military satellites often cost hundreds of millions or billions of dollars apiece, with architectures that rely on small numbers of large satellites that might appear like a sitting duck to an adversary determined to inflict damage.

Four of the small SDA satellites and two larger spacecraft for the Missile Defense Agency were aboard a SpaceX Falcon 9 rocket when it lifted off from Cape Canaveral Space Force Station at 5: 30 pm EST (2230 UTC) Wednesday.

The rocket headed northeast from Cape Canaveral to place the six payloads into low-Earth orbit. Officials from the Space Force declared the launch a success later Wednesday evening.

The SDA’s four tracking satellites, built by L3Harris, are the last spacecraft the agency will launch in its prototype constellation, called Tranche 0. Beginning later this year, the SDA plans to kick off a rapid-fire launch campaign with SpaceX and United Launch Alliance to quickly build out its operational Tranche 1 constellation, with launches set to occur at one-month intervals to deploy approximately 150 satellites. Then, there will be a Tranche 2 constellation with more advanced sensor technologies.

The primary payloads aboard Wednesday’s launch were for the MDA. These two Hypersonic and Ballistic Tracking Space Sensor (HBTSS) satellites, one supplied by L3Harris and the other by Northrop Grumman, will demonstrate medium field-of-view sensors. Those sensors can’t cover as much territory as the SDA satellites but will provide more sensitive and detailed missile tracking data.

This illustration shows how the HBTSS satellites can track hypersonic missiles as they glide and maneuver through the atmosphere, evading detection by conventional missile tracking spacecraft, such as the Space Force's DSP and SBIRS satellites.

This illustration shows how the HBTSS satellites can track hypersonic missiles as they glide and maneuver through the atmosphere, evading detection by conventional missile tracking spacecraft, such as the Space Force’s DSP and SBIRS satellites.

“Our advanced satellites on orbit will bring the integrated and resilient missile warning and defense capabilities the US requires against adversaries developing more advanced maneuverable missiles,” said Christopher Kubasik, chairman and CEO of L3Harris. “L3Harris delivered this advanced missile tracking capability on behalf of MDA and SDA on orbit in just over three years after work was authorized to proceed. We are proud to be a critical part of the new space sensing architecture.”

The HBTSS satellites, valued at more than $300 million, and the SDA’s tracking prototypes will participate in joint military exercises in the coming months, where the wide-view SDA satellites will provide “cueing data” to the MDA’s HBTSS spacecraft. The narrower field of view of the HBTSS satellites can provide more specific, target-quality data to a ground-based interceptor, according to a report last year published by the Congressional Research Service. Future tranches, or generations, of SDA satellites will incorporate the medium field-of-view sensing capability flying on the MDA’s HBTSS satellites.

With SDA taking over the responsibility for making this technology operational, that will leave the MDA, which has historically flown its own missile tracking satellites, focused on next-generation sensor development, an MDA spokesperson told Ars.

Military officials decided only last year to place the four SDA satellites on the same launch as the MDA’s HBTSS mission. With all six satellites flying in the same orbital plane, there will be opportunities to see the same targets with both types of spacecraft and sensors. These targets may include scheduled US military missile tests or foreign launches.

“The intent to be able to work with cooperative and noncooperative targets to be able to do our demonstrations,” a senior SDA official said during a background briefing.

SpaceX launches military satellites tuned to track hypersonic missiles Read More »

spacex-takes-a-proactive-step-toward-responsible-behavior-in-orbit

SpaceX takes a proactive step toward responsible behavior in orbit

orbital debris, Science, Space, spacex, starlink / /

Clearing one’s orbit —

“We commend this commitment as a first step.”

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A group of Starlink satellites assembled and ready for a launch.

Enlarge / SpaceX’s V2 Mini Starlink satellites awaiting launch.

SpaceX

SpaceX announced this week that it will voluntarily bring down about 100 of its first-generation Starlink satellites, which provide broadband Internet from low-Earth orbit, as part of its commitment to “space sustainability.”

The satellites are presently operational and serving Internet customers. However, in a statement, the company said, “The Starlink team identified a common issue in this small population of satellites that could increase the probability of failure in the future.”

This only represents a small fraction of the Starlink megaconstellation, which SpaceX has been launching on Falcon 9 rockets over the last half-decade. To date, SpaceX has put nearly 6,000 satellites into orbit a few hundred kilometers above the planet. This rapid growth in the company’s constellation has raised widespread concerns about the cluttering of low-Earth orbit and the potential for a profusion of debris.

Previously, SpaceX has initiated controlled de-orbits of 406 satellites. The vast majority of these have already entered Earth’s atmosphere and burnt up. However, 17 have become non-maneuverable. These are in decaying orbits and will eventually burn up in Earth’s atmosphere. Until such time, they are being tracked to prevent collisions with other satellites.

In its announcement this week, SpaceX is saying it will bring down about 100 additional Starlink satellites.

Why is SpaceX doing this?

The company said it is being proactive in deciding to bring down satellites that are currently operational.

“While this proactive approach comes at the cost of losing satellites that are serving users effectively, we believe it is the right thing to do to keep space safe and sustainable—SpaceX encourages all satellite owners and operators to safely de-orbit satellites before they become non-maneuverable,” the statement said.

If nothing else, this is a clever public relations move to get out ahead of satellite de-orbits that the space-tracking community would have spotted eventually. SpaceX is controlling the narrative, and it seems to have worked. The release of this information has, based upon several people I have spoken with, engendered goodwill in the community of scientists and activists who worry about orbital debris, clutter, and the sustainability of activity in low-Earth orbit.

However, there appears to be more to this announcement than simple public relations. SpaceX operates nearly two-thirds of all the active satellites in low-Earth orbit, and it is taking responsibility for reducing the likelihood of uncontrolled satellites whizzing around the planet hundreds of kilometers above the surface.

In this sense, SpaceX has taken an important step toward the establishment of a norm: proactive de-orbiting of one’s satellites.

What are the implications of it?

One of the fiercest protectors of low-Earth orbit is Moriba Jah, a co-founder and chief scientist at Privateer, a company that helps monitor congestion in orbit and seeks to enable sustainable growth of the new space economy. Jah told Ars he welcomed this step by SpaceX.

“Ensuring the safety and accessibility of space for all stakeholders is essential and we commend this commitment as a first step,” he said. “Proactive measures to deorbit satellites and share position information represent significant steps toward mitigating the risks associated with space debris.”

However, he added, this is just an interim step toward what should be a long-term goal—the recycling of satellites in space.

“While it may seem economically prudent to deorbit satellites and let them burn up in the atmosphere, the long-term implications of such practices on space sustainability, and the atmosphere itself, cannot be overlooked,” he said. “The long-term path to a circular space economy is in the adoption of reusable and recyclable satellites.”

This approach would reduce the potential for orbital debris and foster a culture of responsible space operations.

There has been some government leadership in this direction. The United States, primarily but not exclusively through NASA, has been pushing for in-space repairing and reviving of satellites to extend their useful lifetimes, including refurbishment activities. Additionally, the European Space Agency has embraced a “Zero Debris Charter” to drive the development of technologies required for no more debris to be left in orbit by 2030.

In releasing this statement, and proactively deorbiting its own spacecraft, the world’s largest operator of satellites has indicated that it wants to play ball.

SpaceX takes a proactive step toward responsible behavior in orbit Read More »

can-you-sanitize-the-inside-of-your-nose-to-prevent-covid?-nope,-fda-says.

Can you sanitize the inside of your nose to prevent COVID? Nope, FDA says.

COVID-19, fda, health, nasal spray, SARS-CoV-2, Science, warning letter / /

doesn’t pass the sniff test —

There are a lot of COVID nasal sprays for sale, but little data to show they work.

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Can you sanitize the inside of your nose to prevent COVID? Nope, FDA says.

More than four years after SARS-CoV-2 made its global debut, the US Food and Drug Administration is still working to clear out the bogus and unproven products that flooded the market, claiming to prevent, treat, and cure COVID-19.

The latest example is an alcohol-based sanitizer meant to be smeared inside the nostrils. According to its maker, the rub can protect you from becoming infected with SARS-CoV-2 and other nasty germs, like MRSA, and that protection lasts up to 12 hours after each swabbing. That all sounds great, but according to the FDA, none of it is proven. In a warning letter released Tuesday, the agency determined the sanitizer, called Nozin, is an unapproved new drug and misbranded.

While ethyl alcohol is used in common topical antiseptics, like hand sanitizers, the FDA does not generally consider it safe for inside the nostrils—and the agency is unaware of any high-quality clinical data showing the Nozin is safe, let alone effective. The FDA also noted that, for general over-the-counter topical antiseptics, calling out specific pathogens it can fight off—like SARS-CoV-2 and MRSA—is not allowed under agency rules without further FDA review. Making claims about protection duration is also not allowed.

The FDA’s warning letter is nothing to sneeze at; the letter threatens seizure and injunction for failing to adequately respond.

Nozin’s maker, Maryland-based Global Life Technologies Corp., did not immediately respond to a request for comment from Ars. On its website, the company touts its product’s effectiveness with a link to a published study from 2014, indicating that use of Nozin lowered the colonization levels of S. aureus and other bacteria in the noses of 20 healthy health care workers. The study did not address protection from infection or carriage of any viruses. The company also lists unpublished studies indicating that the product can kill bacteria in laboratory conditions, does not irritate skin, and lowered bacterial growth in the noses of 30 people over a 12-hour period.

This is far from the first dubious, nasal-based COVID product the FDA has called out. There was the Corona-cure nasal spray of 2020, and the Halodine and the NanoBio Protect nasal antiseptics of 2021. That year, the Federal Trade Commission sued a company called Xlear over allegedly false claims that its nasal spray can prevent and treat COVID-19. At least two more nasal spray makers received FDA warning letters in 2022.

To date, the FDA has not approved any nasal sprays to prevent or treat COVID-19, and the scant data on their efficacy remains inconclusive. But there are still plenty of such products for sale online. Most, like Nozin, claim to work by killing bacteria and viruses directly. One product, a nitric oxide nasal spray called Sanotize, is currently in a Phase III clinical trial to test whether it can prevent SARS-CoV-2 infections. Others claim to work by coating the nasal passage with the gelling agent iota-carrageenan to provide a barrier to viral entry. A pilot clinical trial of 400 health care workers in Argentina published in 2021 found that the use of an iota-carrageenan nasal spray led to a 4 percent absolute risk reduction in SARS-CoV-2 infection.

Can you sanitize the inside of your nose to prevent COVID? Nope, FDA says. Read More »

google,-environmental-defense-fund-will-track-methane-emissions-from-space

Google, Environmental Defense Fund will track methane emissions from space

edf, Energy, Google, methane, Science, Sustainability / /

It’s a gas —

Satellite data + Google Maps + AI should help figure out where methane is leaking.

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computer-generated image of a satellite highlighting emissions over a small square on the globe.

Enlarge / With color, high resolution.

Google/EDF

When discussing climate change, attention generally focuses on our soaring carbon dioxide emissions. But levels of methane have risen just as dramatically, and it’s a far more potent greenhouse gas. And, unlike carbon dioxide, it’s not the end result of a valuable process; methane largely ends up in the atmosphere as the result of waste, lost during extraction and distribution.

Getting these losses under control would be one of the easiest ways to slow down greenhouse warming. But tracking methane emissions often comes from lots of smaller, individual sources. To help get a handle on all the leaks, the Environmental Defense Fund has been working to put its own methane-monitoring satellite in orbit. On Wednesday, it announced that it was partnering with Google to take the data from the satellite, make it publicly available, and tie it to specific sources.

The case for MethaneSAT

Over the course of 20 years, methane is 84 times more potent than carbon dioxide when it comes to greenhouse warming. And most methane in the atmosphere ultimately reacts with oxygen, producing water vapor and carbon dioxide—both of which are also greenhouse gasses. Those numbers are offset by the fact that methane levels in the atmosphere are very low, currently just under two parts per million (versus over 400 ppm for CO2). Still, levels have gone up considerably since monitoring started.

The primary source of the excess methane is the extraction and distribution of natural gas. In the US, the EPA has developed rules meant to force companies with natural gas infrastructure to find and fix leaks. (Unsurprisingly, Texas plans to sue to block this rule.) But finding leaks has turned out to be a challenge. The US has been using industry-wide estimates that turned out to be much lower than numbers based on monitoring a subset of facilities.

Globally, that sort of detailed surveying simply isn’t possible, and we don’t have the type of satellite-based instruments we need to focus on methane emissions. A researcher behind one global survey said, “We were quite disappointed because we discovered that the sensitivity of our system was pretty low.” (The survey did identify sites that were “ultra emitters” despite the sensitivity issues.)

To help identify the major sources of methane release, the Environmental Defense Fund, a US-based NGO, has spun off a project called MethaneSAT that will monitor the emissions from space. The project is backed by large philanthropic donations and has partnered with the New Zealand Space Agency. The Rocket Lab launch company will build the satellite control center in New Zealand, while SpaceX will carry the 350 kg satellite to orbit in a shared launch, expected in early March.

Once in orbit, the hardware will use methane’s ability to absorb in the infrared—the same property that causes all the problems—to track emissions globally at a resolution down below a square kilometer.

Handling the data

That will generate large volumes of data that countries may struggle to interpret. That’s where the new Google partnership will come in. Google will use the same AI capability it has developed to map features such as roads and sidewalks on satellite images but repurpose it to identify oil and gas infrastructure. Both the MethaneSAT’s emissions data and infrastructure details will be combined and made available via the company’s Google Earth service.

Top image: A view of an area undergoing oil/gas extraction. Left: a close-up of an individual drilling site. Right: Computer-generated color coding of the hardware present at the site.

Top image: A view of an area undergoing oil/gas extraction. Left: a close-up of an individual drilling site. Right: Computer-generated color coding of the hardware present at the site.

Google / EDF

The project builds off work Google has done previously by placing methane monitoring hardware on Street View photography vehicles, also in collaboration with the Environmental Defense Fund.

In a press briefing, Google’s Yael Maguire said that the challenge is keeping things up to date, as infrastructure in the oil and gas industry can change fairly rapidly. While he didn’t use it as an example, one illustration of that challenge was the rapid development of liquified natural gas import infrastructure in Europe in the wake of Russia’s invasion of Ukraine.

The key question, however, is one of who’s going to use this information. Extraction companies could use it to identify the sites of leaks and fix them but are unlikely to do that in the absence of a regulatory requirement. Governments could rely on this information to take regulatory actions but will probably want some sort of independent vetting of the data before doing so. At the moment, all EDF is saying is that it’s engaging in discussions with several parties about potentially using the data.

One clear user will be the academic community, which is already using less-targeted satellite data to explore the issue of methane emissions.

Regardless, as everyone involved in the project emphasizes, getting methane under control is probably the easiest and quickest way to eliminate a bit of impending warming. And that could help countries meet emissions targets without immediately starting on some of the slower and more expensive options. So, even if no one has currently committed to using this data, they may ultimately come around—because using it to do something is better than doing nothing.

Google, Environmental Defense Fund will track methane emissions from space Read More »

scientists-found-a-stone-age-megastructure-submerged-in-the-baltic-sea

Scientists found a Stone Age megastructure submerged in the Baltic Sea

Archaeology, megastructures, Science, stone age / /

They built a wall —

“Blinkerwall” may have been a “desert kite,” used to channel and hunt reindeer.

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Graphical reconstruction of a Stone Age wall as it may been used: as a hunting structure in a glacial landscape.

Enlarge / Graphical reconstruction of a Stone Age wall as it may been used: as a hunting structure in a glacial landscape.

Michał Grabowski

In 2021, Jacob Geersen, a geophysicist with the Leibniz Institute for Baltic Sea Research in the German port town of Warnemünde, took his students on a training exercise along the Baltic coast. They used a multibeam sonar system to map the seafloor about 6.2 miles (10 kilometers) offshore.  Analyzing the resulting images back in the lab, Geersen noticed a strange structure that did not seem like it would have occurred naturally.

Further investigation led to the conclusion that this was a manmade megastructure built some 11,000 years ago to channel reindeer herds as a hunting strategy. Dubbed the “Blinkerwall,” it’s quite possibly the oldest such megastructure yet discovered, according to a new paper published in the Proceedings of the National Academy of Sciences—although precisely dating these kinds of archaeological structures is notoriously challenging.

As previously reported, during the 1920s, aerial photographs revealed the presence of large kite-shaped stone wall mega-structures in deserts in Asia and the Middle East that most archaeologists believe were used to herd and trap wild animals. More than 6,000 of these “desert kites” have been identified as of 2018, although very few have been excavated. Last year, archaeologists found two stone engravings—one in Jordan, the other in Saudi Arabia—that they believe represent the oldest architectural plans for these desert kites.

However, these kinds of megastructures are almost unknown in Europe, according to Geersen et al., because they simply didn’t survive the ensuing millennia. But the Baltic Sea basins, which incorporate the Bay of Mecklenburg where Geersen made his momentous discovery, are known to harbor a dense population of submerged archaeological sites that are remarkably well-preserved—like the Blinkerwall.

Morphology of the southwest–northeast trending ridge that hosts the Blinkerwall and the adjacent mound.

Enlarge / Morphology of the southwest–northeast trending ridge that hosts the Blinkerwall and the adjacent mound.

J. Geersen et al., 2024

After they first spotted the underwater wall, Geeren enlisted several colleagues to lower a camera down to the structure. The images revealed a neat row of stones forming a wall under 1 meter (3.2 feet) in height. There are 10 large stones weighing several tons, spaced at intervals, and connected by more than 1,600 smaller stones (less than 100 kilograms or 220 pounds).  “Overall, the ten heaviest stones are all located within regions where the stonewall changes is strike direction,” the authors wrote. The length of the wall is 971 meters (a little over half a mile).

They concluded that the wall didn’t form through natural processes like a moving glacier or a tsunami, especially given the careful placement of the larger stones wherever the wall zigs or zags. It is more likely the structure is manmade and built over 10,000 years ago, although the lack of other archaeological evidence like stone tools or other artifacts makes dating the site difficult. They reasoned that before then, the region would have been covered in a sheet of ice. The immediate vicinity would have had plenty of stones laying about to build the Blinkerwall. Rising sea levels then submerged the structure until it was rediscovered in the 21st century. This would make the Blinkerwall among the oldest and largest Stone Age megastructures in Europe.

As for why the wall was built, Geeren et al. suggest that it was used as a desert kite similar to those found in Asia and the Middle East. There are usually two walls in a desert kite, forming a V shape, but the Blinkerwall happens to run along what was once a lake. Herding reindeer into the lake would have slowed the animals, making them easier to hunt. It’s also possible that there is a second wall hidden underneath the sediment on the seafloor. “When you chase the animals, they follow these structures, they don’t attempt to jump over them,” Geersen told The Guardian. “The idea would be to create an artificial bottleneck with a second wall or with the lake shore.”

3D model of a section of the Blinkerwall adjacent to the large boulder at the western end of the wall.

Enlarge / 3D model of a section of the Blinkerwall adjacent to the large boulder at the western end of the wall.

Philipp Hoy, Rostock University

A similar submerged stone-walled drive lane, known as “Drop 45,” is located in Lake Huron in the US; divers found various lithic artifacts around the drive lane, usually in circular spots that could have served as hunting blinds. The authors suggest that the larger blocks of the Blinkerwall could also have been hunting blinds, although further archaeological surveys will be needed to test this hypothesis.

“I think the case is well made for the wall as an artificial structure built to channel movements of migratory reindeer,” archaeologist Geoff Bailey of the University of York, who is not a co-author on the paper, told New Scientist. Vincent Gaffney of the University of Bradford concurred. “Such a find suggests that extensive prehistoric hunting landscapes may survive in a manner previously only seen in the Great Lakes,” he said. “This has very great implications for areas of the coastal shelves which were previously habitable.”

PNAS, 2024. DOI: 10.1073/pnas.2312008121 (About DOIs).

Scientists found a Stone Age megastructure submerged in the Baltic Sea Read More »

cdc-to-update-its-covid-isolation-guidance,-ditching-5-day-rule:-report

CDC to update its COVID isolation guidance, ditching 5-day rule: Report

CDC, COVID-19, COVID-19 vaccine, health, isolation, masks, Science / /

update —

The agency is reportedly moving from the fixed time to a symptom-based isolation period.

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CDC to update its COVID isolation guidance, ditching 5-day rule: Report

The Centers for Disease Control and Prevention is preparing to update its COVID-19 isolation guidance, moving from a minimum five-day isolation period to one that is solely determined by symptoms, according to a report from The Washington Post.

Currently, CDC isolation guidance states that people who test positive for COVID-19 should stay home for at least five days, at which point people can end their isolation as long as their symptoms are improving and they have been fever-free for 24 hours.

According to three unnamed officials who spoke with the Post, the CDC will update its guidance to remove the five-day minimum, recommending more simply that people can end their isolation any time after being fever-free for 24 hours without the aid of medication, as long as any other remaining symptoms are mild and improving. The change, which is expected to be released in April, would be the first to loosen the guidance since the end of 2021.

In an email to Ars, a CDC spokesperson did not confirm or deny the report, saying only that, “There are no updates to COVID guidelines to announce at this time. We will continue to make decisions based on the best evidence and science to keep communities healthy and safe.”

The Post notes that the proposed update to the guidance matches updated guidance from California and Oregon, as well as other countries.

The officials who spoke with the outlet noted that the loosened guidelines reflect that most people in the US have developed some level of immunity to the pandemic coronavirus from prior infections and vaccinations.

A report earlier this month found that the 2023–2024 COVID-19 vaccine was about 54 percent effective at preventing symptomatic COVID-19 when compared against people who had not received the latest vaccine. However, the CDC estimates that only about 22 percent of adults have received the updated shot.

Currently, the CDC recommends that people wear a mask for 10 days after testing positive unless they have two negative tests 48 hours apart. The Post reported that it’s unclear if the CDC will update its mask recommendation.

CDC to update its COVID isolation guidance, ditching 5-day rule: Report Read More »

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Judge tosses Big Pharma suit claiming drug price negotiation is unconstitutional

Astrazeneca, drug pricing, health, medicare, Pharmaceutical industry, PhRMA, Science / /

tossed —

The judge ruled that the court lacks jurisdiction.

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Stephen Ubl, president and chief executive officer of Pharmaceutical Research and Manufacturers of America (PhRMA), speaks during a Bloomberg Live discussion in Washington, DC, on Tuesday, Sept. 19, 2017.

Enlarge / Stephen Ubl, president and chief executive officer of Pharmaceutical Research and Manufacturers of America (PhRMA), speaks during a Bloomberg Live discussion in Washington, DC, on Tuesday, Sept. 19, 2017.

A federal judge in Texas dismissed a lawsuit Monday brought by a heavy-hitting pharmaceutical trade group, which argued that forcing drug makers to negotiate Medicare drug prices is unconstitutional.

The dismissal is a small win for the Biden administration, which is defending the price negotiations on multiple fronts. The lawsuit dismissed Monday is just one of nine from the pharmaceutical industry, all claiming in some way that the price negotiations laid out in the Inflation Reduction Act of 2022 are unconstitutional. The big pharmaceutical companies suing the government directly over the negotiations include Johnson & Johnson, Bristol Myers Squibb, Novo Nordisk, Merck, and AstraZeneca.

Last month, a federal judge in Delaware heard arguments from AstraZeneca’s lawyers, which reportedly went poorly. AstraZeneca argued that Medicare’s new power to negotiate drug prices violates the company’s rights under the Fifth Amendment’s due process clause. The forced negotiations deprive the company of “property rights in their drug products and their patent rights” without due process, AstraZeneca claimed. But Colm Connolly, chief judge of the US District Court of Delaware, was skeptical of how that could be the case, according to a Stat reporter who was present for the hearing. Connolly noted that AstraZeneca doesn’t have to sell drugs to Medicare. “You’re free to do what you want,” Connolly reportedly said. “You may not make as much money.”

At a later point, Connolly bluntly commented: “I don’t find their argument compelling.”

Though the plaintiffs in the now-dismissed Texas also made an argument based on the Fifth Amendment’s due process clause, the case didn’t make it that far. US District Judge David Ezra in Austin, Texas, dismissed the case brought by one of the case’s three plaintiffs, saying the court lacked jurisdiction. And, because that one plaintiff is the only one based in the Western District of Texas, where the lawsuit was filed, he dismissed the case completely.

The three plaintiffs in the case were PhRMA, a powerful drug industry trade group representing high-profile drug makers, including Pfizer, GSK, Eli Lilly, and Sanofi; the Global Colon Cancer Association (GCCA); and the Texas-based National Infusion Center Association (NICA). Lawyers for the Biden administration filed a motion to dismiss the case, arguing that NICA is not a proper plaintiff.

Ezra found that for NICA to bring constitutional claims against Medicare’s price negotiations in a court, it is first required under federal rules to bring those claims through an administrative review process under the Medicare Act or the Centers for Medicare and Medicaid Services. Without a prior administrative review, the court has no jurisdiction.

“The Court lacks jurisdiction over NICA’s claims because the claims here ‘arise under’ the Medicare Act and the claims do not fall under the exception carved out for when claims may completely avoid judicial or administrative review. Therefore, NICA’s claims are dismissed without prejudice,” Ezra wrote in his ruling.

And, with the one Texas-based plaintiff, NICA, knocked out of the case, the Western Texas district is now the “improper venue” for a case brought by the remaining two plaintiffs, PhRMA and GCCA.

Ezra noted that in such situations, a judge can transfer the case to a court that would be considered a proper venue. But Ezra declined, noting that neither the plaintiffs nor defendants suggested a proper venue. And, even if they did, it likely wouldn’t matter, Ezra reasoned, because PhRMA and GCCA also haven’t gone through an administrative review.

“[T]he same federal jurisdictional defect likely exists for PhRMA and GCCA, as nothing suggests that either party has presented its claims to the [Health] Secretary,” Ezra wrote.

Ezra dismissed the case “without prejudice,” meaning the claims could be refiled. A spokesperson for PhRMA told FiercePharma: “We are disappointed with the court’s decision, which does not address the merits of our lawsuit, and we are weighing our next legal steps.”

Meanwhile, the first round of Medicare drug price negotiations is underway. Earlier this month, the federal government sent out its opening offers in the price negotiation process for the first 10 drugs selected. The bargaining will continue through the coming months, with an ending deadline of August 1, 2024. The prices will go into effect at the beginning of 2026.

Judge tosses Big Pharma suit claiming drug price negotiation is unconstitutional Read More »

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“Very sick” pet cat gave Oregon resident case of bubonic plague

bubonic plague, cat, CDC, fleas, infection, infectious diseases, Oregon, plague, rodents, Science, yersinia pestis / /

Surprise plague —

The person’s cat was reportedly extremely ill and had a draining abscess.

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A cat, but not the one with plague.

Enlarge / A cat, but not the one with plague.

An Oregon resident contracted bubonic plague from their “very sick” pet cat, marking the first time since 2015 that someone in the state has been stricken with the Black Death bacterium, according to local health officials.

Plague bacteria, Yersinia pestis, circulates cryptically in the US in various types of rodents and their fleas. It causes an average of seven human cases a year, with a range of 1 to 17, according to the Centers for Disease Control and Prevention. The cases tend to cluster in two regions, the CDC notes: a hotspot that spans northern New Mexico, northern Arizona, and southern Colorado, and another region spanning California, far western Nevada, and southern Oregon.

The new case in Oregon occurred in the central county of Deschutes. It was fortunately caught early before the infection developed into a more severe, systemic bloodstream infection (septicemic plague). However, according to a local official who spoke with NBC News, some doctors felt the person had developed a cough while being treated at the hospital. This could indicate progression toward pneumonic plague, a more life-threatening and more readily contagious variety of the plague that spreads via respiratory droplets. Nevertheless, the person’s case reportedly responded well to antibiotic treatment, and the person is recovering.

Health officials worked to prevent the spread of the disease. “All close contacts of the resident and their pet have been contacted and provided medication to prevent illness,” Richard Fawcett, Deschutes County Health Officer, said in a news release.

Fawcett told NBC News that the cat was “very sick” and had a draining abscess, indicating “a fairly substantial” infection. The person could have become infected by plague-infected fleas from the cat or by handling the sick cat or its bodily fluids directly. Symptoms usually develop two to eight days after exposure, when the infection occurs in the lymph nodes. Early symptoms include sudden onset of fever, nausea, weakness, chills, muscle aches, and/or visibly swollen lymph nodes called buboes. If left untreated, the infection progresses to the septicemic or pneumonic forms.

It’s unclear how or why the cat became infected. But cats are particularly susceptible to plague and are considered a common source of infection in the US. The animals, when left to roam outdoors, can pick up infections from fleas as well as killing and eating infected rodents. Though dogs can also pick up the infection from fleas or other animals, they are less likely to develop clinical illness, according to the CDC.

While plague cases are generally rare in the US, Deschutes County Health Services offered general tips to keep from contracting the deadly bacteria, namely: Avoid contact with fleas and rodents, particularly sick, injured, or dead ones; Keep pets on a leash and protected with flea control products; Work to keep rodents out and away from homes and other buildings; and avoid areas with lots of rodents while camping and hiking and wear insect repellant when outdoors to ward off fleas.

According to the CDC, there were 496 plague cases in the US between 1970 and 2020. And between 2000 and 2020, the CDC counted 14 deaths.

“Very sick” pet cat gave Oregon resident case of bubonic plague Read More »

building-durable-basketball-players-from-the-ground-up-(way-up)

Building durable basketball players from the ground up (way up)

Science / /

he got game (and a good stretching regimen) —

Can new scientific insights help the newest crop of NBA stars stay healthy?

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Victor Wembanyama of the San Antonio Spurs drives on Moritz Wagner of the Orlando Magic

Enlarge / Victor Wembanyama of the San Antonio Spurs drives on Moritz Wagner of the Orlando Magic during a game on February 8 in Orlando, Florida.

The NBA’s tallest rookie is 7 feet 4 inches tall with an 8-foot wingspan, but last year, a series of video clips highlighted his surprisingly nimble, and often shoeless, feet. In one clip, he’s pressing knees and ankles together while wiggling his toes and hopping forward. In another, he’s bear crawling along the baseline. And in yet another, his right heel and left toes are gliding in opposite directions, gym music pounding in the background, as he eases into the splits.

Victor Wembanyama (pronounced wem-ben-YAH-muh), was selected first in last June’s NBA draft at the age of 19. By then, he had played four years of professional basketball in his native France. With a preternatural blend of size, athleticism, and skill, Wembanyama is routinely described as a generational talent. And if the toe-exercise videos are any indication, his trainers appear determined to protect that talent: Sports medicine experts say that long limbs and feet—Wembanyama’s shoe size is 20.5—confer potential physical vulnerabilities.

Leg, arm, and foot bones all function like levers, and the longer they are, the more force is needed to stabilize them. Tall athletes may find it harder to control their movement as they land from a jump or quickly shift direction. Seven-footers, of course, aren’t the only athletes who get hurt while playing. Across the NBA, injuries are on the rise, with knee, ankle, and foot problems leading the way. Anecdotally, physicians and trainers also report seeing children, some as young as 10 years old, with severe sports-related injuries and chronic wear-and-tear that was once seen mainly in adults.

All of this has fueled a small but growing body of scientific research into basketball and other sports-related injuries. In biomechanics laboratories, experts are creating detailed assessments of how players move on the court. Epidemiologists are poring over reams of data. And NBA teams have been experimenting with new approaches for player safety, including an emphasis on load management, which seeks to optimize an athlete’s ratio of stress to rest.

Much of this science is still unsettled, and there is no foolproof method for injury prevention. But experts who spoke with Undark said there is a solid evidence base for specific warm-up programs, stretches, and exercises that reduce injuries. The findings have not been fully disseminated and implemented. Yet, there’s clearly interest in the topic.

The shoes of Victor Wembanyama, size 20.5, before a game in January. Across the NBA, injuries are on the rise, with knee, ankle, and foot problems leading the way. And experts say long limbs and feet confer potential physical vulnerabilities.

Enlarge / The shoes of Victor Wembanyama, size 20.5, before a game in January. Across the NBA, injuries are on the rise, with knee, ankle, and foot problems leading the way. And experts say long limbs and feet confer potential physical vulnerabilities.

Wembanyama’s barefoot calisthenics have inspired explanatory videos with titles like “Victor Wembanyama’s Weird Toe Workout EXPLAINED!” as well as comments and replies asserting that such exercises could have benefitted previous generations of tall players. “This is smart they’re trying to keep his feet healthy,” wrote a New York Knicks superfan on X, formerly known as Twitter. “[Too] many big men have gone down with foot injuries.”

Danny Seidman, a Michigan-based sports medicine physician (and self-described NBA fanatic), said he’s glad the videos went viral. They got people talking about injury prevention, which has come a long way over the past few decades. “It’s sad for me to see previous athletes in their 50s and 60s who are limping around or hunched over,” said Seidman. “We think we can avoid those sorts of things now.”

Building durable basketball players from the ground up (way up) Read More »

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Fake grass, real injuries? Dissecting the NFL’s artificial turf debate

american football, astroturf, Features, Football, nfl, Science, sports injuries, Super Bowl, super bowl lviii / /
Fake grass, real injuries? Dissecting the NFL’s artificial turf debate

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Super Bowl LVIII will be played on a natural grass field in an indoor stadium in Las Vegas on February 11, 2024. How do you keep a grass field vibrant in such a hostile growing environment like the Nevada desert?

The answer: You don’t. By the end of the regular NFL season, paint was used to camouflage the reality that only a few scant patches of grass remained in Allegiant Stadium, home to the Las Vegas Raiders. Immediately after the Raiders’ last game on January 7, 2024, the field crew ripped up the remaining grass, installed California-grown sod over three days, and began the tedious process of keeping the grass alive long enough for the big game.

Herculean efforts to prepare a vibrant natural grass field for 2024’s Super Bowl LVIII are especially questionable when one realizes that Allegiant Stadium also has an artificial turf playing surface available (used by UNLV Football). Why don’t teams in hostile environments switch to more robust artificial turf, which is designed to overcome the many limitations of natural grass fields?

The answer lies in a debate over the safety of synthetic playing surfaces. While artificial turf manufacturers tout research that their products result in fewer injuries, the NFL Players Association (NFLPA) claims it raises injury risk and is advocating for its use to be abolished in the NFL. Let’s explore some key arguments of this debate, which continues to grab headlines with each high-profile NFL injury.

Super Bowl gridirons

Pressure for NFL field managers is especially high following the embarrassingly poor field conditions of last year’s Super Bowl. Super Bowl LVII took place at State Farm Stadium in Glendale, Arizona—another natural grass field in the desert (with a retractable roof, closed at night to protect the grass). Despite two years of preparation and an $800,000 investment, the grass field was a disaster, as players struggled to find footing on its slippery surface.

Veteran NFL groundskeeper George Toma attributed the mess to woefully improper field preparation. Players also complained about the slipping issue the previous time the Super Bowl was hosted at the natural grass field in State Farm Stadium eight years prior for Super Bowl XLIX in 2015. That year, the poor traction was blamed on the green paint used on the grass.

For perspective, some of the best sports field managers in the nation oversee field preparations for the Super Bowl. However, maintaining natural grass in desert conditions is so unfavorable (especially when the grass is sometimes indoors) that even the best can mess it up.

None of these issues existed when the Super Bowl was last played on artificial turf. Super Bowl LVI in 2022 was held at SoFi Stadium in Inglewood, California, home to both the Los Angeles Rams and Chargers. Not only did the artificial turf stand up to double the workload during the regular season (hosting home games for the LA Rams and the LA Chargers), but it also withstood a busy playoff season. The artificial turf field at SoFi Stadium hosted NFL games through the regular season and right up to the last playoff game when the LA Rams beat the San Francisco 49ers. Two weeks later, the Rams ended up winning Super Bowl LVI on the very same surface.

While turf avoids the durability issues seen with grass surfaces, players have widespread concerns about its safety—a recent poll by the NFLPA reported 92 percent of players favored grass.

Fake grass, real injuries? Dissecting the NFL’s artificial turf debate Read More »