psilocybin

Illegal drug found in Diamond Shruumz candies linked to severe illnesses

diamond shruumz, hallucinogenic, health, muscimol, Mushroom, poison, psilocin, psilocybin, psychedelics, Science / Paul Patrick / July 19, 2024

More drugs —

New testing finds psilocin, related to psilocybin, in gummies purchased in 2023.

Beth Mole – Jul 19, 2024 5: 59 pm UTC

Newly released testing data of Diamond Shruumz-brand gummies purchased in 2023 identified the presence of psilocin, a hallucinogenic drug closely related to the magic-mushroom drug psilocybin that is classified as a Schedule I drug, alongside psilocybin, heroin, and LSD.

The finding comes as Diamond Shruumz’s current line of gummies, chocolates, and candy cones is being recalled and are under active investigation in connection to a nationwide rash of severe illnesses, which have involved seizures, intubation, and intensive care. As of the latest update on July 15, 69 people in 28 states have been sickened after eating a Diamond Shruumz product. Sixty of the 69 sought medical care, 36 were hospitalized, and there is one potentially associated death under investigation.

The new finding of psilocin in the products, published by researchers at the University of Virginia, adds to growing concern about psychedelic mushroom candies generally. Although the candies are marketed as being legal, they have often been found to contain various undisclosed illegal drugs, gray market synthetic versions of drugs, as well as dangerous adulterants and contaminants.

In the ongoing investigation of Diamond Shruumz candies—led by the Food and Drug Administration and the Centers for Disease Control and Prevention, with the help of America’s Poison Centers and state and local partners—researchers have not identified psilocin in products linked to the illnesses. Instead, they have found a closely related synthetic hallucinogenic compound called 4-acetoxy-N,N-dimethyltryptamine, also known as psilacetin or 4-AcO-DMT. Psilacetin is thought to be metabolized into psilocin in the body and is said to have similar effects as taking magic mushrooms or psilocybin. The different testing results between the FDA-led investigation and the new UVA study may be due to possible formulation changes between 2023 and 2024 or simply differences in the products or batches of candies tested so far.

The UVA researchers, who published their findings in the CDC’s Morbidity and Mortality Weekly Report, looked into the mushroom candies after four adults reported illnesses to a local poison control center between September and November 2023. The people went to the emergency department with tachycardia, confusion, anxiety or somnolence, and nausea after eating gummy candies labeled as containing Amanita muscaria mushrooms. Amid their investigation into those cases, a 3-year-old also fell ill in June 2024 after accidentally eating two gummies sold as containing A. muscaria. All of the adults and the toddler recovered from their illnesses quickly, though the toddler was hospitalized for a day for observation.

Not legal or safe

A. muscaria is a legal hallucinogenic mushroom that contains psychoactive compounds ibotenic acid and muscimol. These resemble neurotransmitters in the brain and can cause gastrointestinal symptoms, agitation, and seizures.

The UVA researchers couldn’t track down the specific brands or products the sickened adults took, but they collected six similar products from nearby gas stations and smoke shops. Those six products included two Diamond Shruumz products, which were not sold as containing A. muscaria. Using liquid chromatography-mass spectrometry, the researchers found that the two Diamond Shruumz gummy products (Sour Peach Apple and Rainbow flavors) contained psilocin. The Rainbow flavor also contained caffeine.

In addition, a product labeled as “Wonderland Legal Psychedelics Cherry Nirvana” contained psilocin, the synthetic hallucinogen N,N-dimethyltryptamine, a compound found in kratom called mitragynine, and caffeine. A product labeled as “Urb Magic Amanita Mushroom Watermelon” contained psilocybin, psilocin, and the stimulant 2-phenethylamine. A product called “Psilly’s Legal Psychedelic Mushrooms Fruit Punch” contained the stimulant ephedrine, and the product “Tryp mushroom gummies” wasn’t found to contain any concerning compounds.

The UVA study was not able to test for ibotenic acid or muscimol. In Diamond Shruumz’s recall notice, the company said it had found higher than normal levels of muscimol in its products. FDA testing has not identified muscimol in product testing, according to results released so far.

“People tend to equate ‘legal’ with ‘safe,’ which is not necessarily the case. These products are not regulated and can contain any number of unlabeled substances which, when consumed, can cause undesired symptoms,” lead author of the UVA study Avery Michienzi said in a statement. “Some packages will have QR codes showing that the products were tested in a lab and contain only what they are labeled to contain. These have been found to be inaccurate.”

The FDA this week warned that even though all of Diamond Shruumz’s products have been recalled, they remain on the shelves of stores nationwide. The agency said it is reaching out to industry partners to raise awareness of the recall and monitoring the effectiveness of Diamond Shruumz’s recall efforts.

Illegal drug found in Diamond Shruumz candies linked to severe illnesses Read More »

Synthetic psychedelic found in candies linked to seizures, intubation

Toxic trip —

Cases grow to 39, including 23 hospitalizations, across 20 states.

Beth Mole – Jun 26, 2024 7: 43 pm UTC

Enlarge / A Diamond Shruumz chocolate bar, which comes in a variety of flavors.

The US Food and Drug Administration has identified a synthetic psychedelic compound as well as compounds from a potentially toxic plant in the Diamond Shruumz-brand microdosing candies linked to a growing number of severe illnesses nationwide that have included seizures, intubation, and admissions to intensive care units.

As of June 25, the case total has grown to 39, including 23 hospitalizations, across 20 states, the FDA and the Centers for Disease Control and Prevention reported.

It remains unclear what is in the candies and what may be causing the severe illnesses. Diamond Shruumz does not provide a full list of ingredients. The term “microdosing” and other marketing used by Diamond Shruumz suggests the candies contain a psychedelic compound, but the company does not name any. To figure it out, the FDA has been analyzing multiple samples of Diamond Shruumz-brand candies, including chocolates, gummies, and candy cones. On Tuesday, the FDA reported finding the synthetic psychedelic compound 4-AcO-DMT in the company’s Dark Chocolate Bar and its Birthday Cake Chocolate Bar.

As Ars reported previously, 4-AcO-DMT (aka 4- acetoxy-N,N-dimethyltryptamine, O-acetylpsilocin, or psilacetin) is a common synthetic tryptamine used in psychedelics and was previously suspected to be in the Diamond Shruumz candies. The psychoactive drug has a chemical structure similar to the most notable mushroom-derived psychedelic, psilocybin, as well as LSD. Though safety data on the compound is scant, it is not known to be linked to some of the severe symptoms seen in the current string of illnesses. People who use 4-Aco-DMT describe it as producing effects similar to psilocybin, but without some of the unpleasant side effects noted with natural mushrooms, such as nausea. Still, according to the CDC, some people who use it could experience nausea, vomiting, fast heart rate, anxiety, agitation, lightheadedness, or tremor.

Additionally, the FDA found three compounds from the Kava plant (Piper methysticum) in the company’s dark chocolate bar, though not the birthday-cake flavored bar. The compounds are kavalactones—desmethoxyyangonin, dihydrokavain, and kavain.

Concerning kava

Kava is a plant found on some Pacific Islands and is used in traditional herbal remedies for the treatment of anxiety, insomnia, stress, and other ailments. But, over the years, it has also occasionally been linked to severe liver toxicity. In the early 2000s, this led to warnings, withdrawals, and even bans in several countries, including Germany, Switzerland, France, Canada, and the UK. In 2002, the FDA issued an advisory of its own over the associated liver injuries, which include hepatitis, cirrhosis, and liver failure. Later that same year, researchers published case reports of 11 people (two in the US and nine in Europe) who developed liver failure after using kava products and needed subsequent liver transplants.

In an update on the illnesses linked to Diamond Shruumz candies, the CDC noted that kava can cause numbness of the mouth and skin, loss of coordination, dizziness, sedation, and gastrointestinal effects, such as nausea and vomiting. Consuming kava products alongside alcohol or drugs like benzodiazepines (e.g. Valium and Xanax) can heighten the sedative effects. But, the CDC seemed to downplay the risk of liver toxicity here, noting that it has only occasionally been associated with chronic or heavy ingestion of kava.

In all, it’s still unclear if the compounds the FDA identified in the Diamond Shruumz chocolate bars so far can explain the illnesses seen in the linked cases. The CDC lists the severe and common symptoms from those cases as including seizures, decreased level of consciousness, respiratory failure, nausea, vomiting, abdominal pain, hallucinations, uncontrolled movements, abnormal heart rate (e.g., too fast or too slow), high or low blood pressure, excessive sweating or secretions, and flushed skin.

The FDA said testing of other Diamond Shruumz products is still in progress. The agency noted that there can be differences across products and batches. In the meantime, the agency advises consumers not to eat, sell, or serve any of the company’s products and, instead, discard them.

There is still no recall of the candies. Diamond Shruumz has not responded to multiple inquiries from Ars. The FDA said Tuesday that the agency has “been in contact with the firm about a possible voluntary recall,” but to date, Diamond Shruumz has not initiated one.